关键词： 催化剂结构   不对称反应   有机小分子   不对称合成   外消旋体拆分   高效催化   催化研究   催化剂研究   光学活性   过渡金属催化剂  

摘要： Asymmetric organocatalysts has been increasingly recognized as an important green alternative the highly-developed asymmetric transition metal catalysis and biotransformation. However, organocatalysis is just in its infancy and has many limitations such low efficiency and limited substrate scopes. We presented herein a novel strategy to address the above challenges by incorporating ionic-liquid moieties as building blocks for organocatalysts. The chiral ionic-liquid (CIL) organocatalysts still maintained the unique properties of ionic liquid, and meanwhile, served as efficient catalyst for judiciously selected reactions. The CIL organocatalysts were shown to be highly efficient and stereoselective catalysts for asymmetric Michael additions. By simple swap of the ionic liquid anion with a surfactant anion, a highly efficient catalysis was realized for the first time in pure water.

关键词： 生物催化   不对称合成   酶   生物转化  

摘要： 生物催化手性合成是近些年来备受关注的一个重大课题,生物催化的手性合成反应条件温和、环境友好、高效率和高选择性。这使它成为当今手性合成方法研究的热点和发展方向。本文就近几年来,尤其是2000年以来在这些方面的研究进展作一总结。

关键词： 不对称二羟化   不对称合成   手性连二醇   手性β-叠氮醇   手性β-氨基醇   (S)-(+)-2-(2-萘)-2-N-甲基氨乙醇  

摘要： 以β-萘乙烯为原料，通过烯烃的Sharpless不对称双羟化、环化、开环、催化氢化、甲酰化、还原等6步反应，生成标题化合物，总产率以β-萘乙烯计为39．7％，e．e．值高达97％-99％。对产物进行了质谱、红外光谱、^1HNMR和^13CNMR表征。

关键词： 1,3-proton shift reaction   fluorine and compounds   imines   operationally convenient conditions   biomimetic reductive amination   cinchonidine derived bases   catalytic asymmetric synthesis  

摘要： Here we describe catalytic asymmetric synthesis of alpha-(trifluoromethyl)benzylamine (1) via biomimetic transarnination using chiral base. Imine 4 was isomerized to Schiff base 5 using 50 mol.% of cinchonidine derivatives as a catalyst in chloroform, methanol or acetonitrile. In the case of cinchonidine 6 as a catalyst, the reaction conducted in chloroform allowed for 79% conversion of the starting imine 4 in 52 days. The product imine 5 was obtained of (R) absolute configuration in 35% ee as individual compound without any byproducts. The catalyst 6 can be recovered (> 95%) by adding n-hexane to the reaction mixture followed by a simple filtration. (c) 2006 Elsevier B.V. All rights reserved.

关键词： homogeneous catalysis   asymmetric synthesis   organometallic chemistry   ligand design  

摘要： The present article provides an overview of the basic principles of asymmetric catalysis. An outline of the methodologies useful for the synthesis of chiral non-racemic products is given as well. Merits and drawbacks of each technique are commented.

关键词： Asymmetric synthesis.  

ISBN: (数字)9783527610648 ISBN: (纸本)9783527314737

摘要： Edited by two of the leading researchers in the field, this book provides a deep, interdisciplinary insight into stoichiometric and catalytic reactions in this continuously expanding area. A plethora of top German scientists with an international reputation covers various aspects, from classical organic chemistry to process development, and from the theoretical background to biological methods using enzymes. Throughout the focus is on the development of new synthetic methods in asymmetric synthesis, the synthesis of natural and bioactive compounds and the latest developments in both chemical and biological methods of catalysis, as well as the investigation of special technical and biotechnical aspects.

关键词： (S)-对羟基苯基乳酸衍生物   不对称合成   L酪氨酸苄醚   重氮化反应   (S)-3-对苄氧基苯基乳酸  

摘要： 光学纯的(S)-对羟基苯基乳酸衍生物是合成新型抗糖尿病药物和混杂多肽的有价值的关键中间体。综述了合成(S)-对羟基苯基乳酸衍生物的各种方法,并分析了各种合成方法的优缺点。

关键词： 光学活性药物   手性   不对称合成  

摘要： 药物分子的立体化学决定其药效,不对称合成光学活性药物已成为一个极具潜力的研究方向。本文综述了近年来不对称合成在光学活性药物合成中的应用与进展,着重讨论了催化不对称合成的应用与进展。

关键词： 脯氨酸   Michael反应   不对称合成   催化  

摘要： 综述了脯氨酸催化的直接不对称Michael反应的研究进展,包括脯氨酸作为催化剂在有机溶剂、离子液体溶剂条件下的反应以及脯氨酸催化的放大效应;介绍了脯氨酸衍生物作为催化剂的Michael反应,以及脯氨酸催化的Michael反应与其他反应的复合反应等。

关键词： Heck反应   钯   催化   不对称合成   应用  

摘要： Heck反应是一类重要的卤代芳烃烯基化、形成新的C—C键的合成反应,近几年来一直是催化化学和有机化学的研究热点.总结了最近几年来国内外Heck反应新型催化体系、不对称Heck反应、Heck反应在有机合成中的最新应用等重要研究成果,希望引起同行对Heck反应的关注.