关键词： Organic compounds  

摘要： Enantiopure N-sulfinyl-delta-amino-beta-ketoesters and isoquinolones, prepared from sulfinimines (N-sulfinyl imines) are a new class of polyfunctionalized chiral building blocks. These building blocks provide easy access to enantiomerically pure, functionalized piperidines and tetrahydroisoquinolines with a minimum of chemical manipulation and protecting-group chemistry. (C) 2002 Wiley Periodicals, Inc.

关键词： AMINO alcohols   ORGANIC chemistry  

摘要： tert-Butanesulfinyl aldimines and ketimines bearing an alpha -benzyloxy or alpha -silyloxy substituent serve as precursors in the synthesis of protected 1,2-amino alcohols in high yields and diastereoselectivities. General protocols are described for the addition of unbranched alkyl, branched alkyl, and aryl organometallic reagents to N-sulfinyl aldimines 1 and 2 and ketimines 5 and 6. Furthermore, the selective N- or O-deprotection of sulfinamide products 3, 4, 7, and 8 is described, enabling further synthetic transformations of the reaction products.

关键词： MANNICH reaction   ASYMMETRIC synthesis  

摘要： The Mannich reaction involving enolizable azomethine compounds in most casesfails to give good results due to the preference of the azomethine substrate to undergo enolizationrather thant he desired nucleophilic addition. There are only a few procedures that overcome theselimitations, and in this context, modified derivatives of either the enolate or the azomethynereagent have been employed.

关键词： Lactones   Peptides and proteins   Monomers   Organic reactions   Chemical reactions  

摘要： [GRAPHICS] Wittig reaction of (triphenylphosphoranylidene)acetonitrile with the lactone carbonyl of (5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one (3) and subsequent reduction generates morpholinylethylamine dihydrochloride (5) in quantitative yield and with excellent diastereoselectivity. Compound 5 was readily converted into hypusine dihydrochloride (1-2HCl) in overall 53% yield.

关键词： 手性氨基酚   不对称合成  

摘要： 手性氨基-羟基化合物是一类用于催化不对称合成和手性辅助合成的重要配体.已经被成功开发的氨基醇配体绝大多数起始于手性源化合物.但是,非手性源的氨基-羟基手性配体的设计和合成已经成为目前不对称合成研究中的一个重要内容和发展趋势.因此,在天然手性源中几乎不存在的、或者不易从天然手性源转化得到的手性氨基酚将是一类重要的研究目标.该文选择了Betti碱及其手性衍生物为研究目标,完成了Betti碱拆分、手性配体结构的合成,以及它们在催化不对称合成和手性辅助合成中的应用.

关键词： 联二萘酚   氨基酸   不对称合成   动力学拆分   杂多酸化合物  

摘要： 该文利用HbbImed、TMEDA和TAC、PAC（L-脯氨酸）分子之间的非共价键相互作用而形成手性盐,研究了它们在化学拆分（±）-BINOL中的立体选择性活生,并对其动力学拆分性能进行了比较.以CuCl（OH）-TMEDA为催化剂,以不同苯并咪唑化合物HbbImed、bbImpa、bbImea及TAC、GAC、AsAc、PAC等廉价的氨基酸为手性诱导试剂,研究了它们在β-萘酚不对称氧化偶合反应中的化学选择性和立体选择性.以L-脯氨酸、TMEDA和氯化亚铜为原料合成了手性催化剂（PTCu）,采用1.5%mol的催化剂量,利用空气氧化讨论了光活性联二萘酚的不对称合成方法.首次制备了钆（Ⅲ）-钨和铜（Ⅱ）-钨手性异核双金属杂多酸化合物GdCl<,2>-EDTB-H<,3>SiW<,2>O<,40>、CuCl-HbbImed-H<,2>SiW<,12>O<,40>,并对其进行了IR、<\'1>H-NMR及元素分析等表征.

关键词： α-氨基酸   氨基酸   不对称合成   进展   综述  

摘要： 综述了近年来α

关键词： 催化剂   不对称合成   诺贝尔化学奖   2001年   沙普利斯   诺尔斯   野依良治  

摘要： 20 0 1年诺贝尔化学奖授予了美国化学家沙普利斯教授 (占 1 2 )及诺尔斯博士与日本化学家野依良治教授 (合1 2 ) ,以表彰他们在发展催化不对称合成的新方法技术及其应用于工业生产研究领域中的开创性贡献 .本文对催化不对称合成的基本概念及技术与三位杰出科学家的贡献作了简要的介绍 .

关键词： 不對稱合成   掌性輔助基   樟腦   樟腦磺醯胺   α-胺基酸   乙醇酸   硫醇乙酸  

摘要： 本报告谨将作者於近十几年来任职国立清华大学化学系，利用樟脑及樟脑磺醯胺做为掌性辅助基进行不对称合成研究，由甘胺酸(glycine)、乙醇酸(glycolic acid)及硫醇乙酸(thioglycolic acid)合成α-取代及α,α-双取代衍生物上的研究情形作回顾性整理。

关键词： Alcohols   Ketones   Stereoselectivity   Catalysts   Molecular structure  

摘要： It is desirable and practical to produce both enantiomers of a target from the same chiral starting material by stereodifferentiation of prochiral compounds, for instance utilizing a chiral ligand derived from a natural (L) amino acid. During the past 7 years, excellent results have been achieved in several cases by multiple stereodifferentiation of chiral ligands derived from (S)-indoline-2-carboxylic acid: highly diastereo- and enantioselective pinacol coupling reactions of chiral alpha -ketoamides gave both (S,S)- and (R,R)-quaternary tartaric acid for the first time;asymmetric Diels-Alder cyclization of chiral acrylamides in the presence of Lewis acid afforded extremely high diastereoselectivities of both opposite configurations of the cyclized diastereomers depending upon the structures of chiral ligands and Lewis acids;and asymmetric alkylation of aldehydes to both enantiomers of secondary alcohols and asymmetric hydrogenation of ketones to both enantiomers of chiral secondary alcohols have been achieved using catalysts derived from (S)-indoline-2-carboxylic acid.