关键词： 不对称合成   二羟基化   催化剂  

摘要： 综述了不对称二羟基化反应的一般原理、反应历程，介绍了常用配体的种类、合成方法、应用范围和反应条件以及不对称二羟基化反应在有机合成中的应用。

关键词： 宁夏回族自治区   医药卫生   生物活性   天然产物   不对称合成   先导化合物   小叶黑柴胡   科技进步奖   脑脊液细胞   医用化学  

摘要： 1998年4月,自治区卫生厅组织区内专家,对1995～1997年度经过登记后申报全区医药卫生科技进步奖的科技成果进行评审,评选出58项医药卫生科技进步奖项目。现将重点成果做一简介。 (一)基础医学 1.医用化学以具有生物活性的天然产物为先导化合物。

关键词： Group 15 compounds   Functionalization   Organophosphorus compounds   Ethyl groups   Ligands  

摘要： Presents information on a study which demonstrates the spectacular efficiency of functionalized diphosphines as chiral auxiliaries in homogenous asymmetric catalysis. Methodology of the study; Results and discussion.

关键词： Alcohols   Oscillation   Ethers   Molecular structure   Pharmaceuticals  

摘要： Details the synthesis of the C9-C21 portion of the aplysiatoxin and oscillatoxin marine natural products. Experimental procedures.

关键词： photochemical reaction   Asymmetric synthesis  

摘要： The first chiral auxiliary-mediated asymmetric synthesis of (-)-perhydrohistrionicotoxin is described.

关键词： Alcohols   Aldehydes   Chromatography   Molecular structure   Post-translational modification  

摘要： Proposes chiral auxiliaries with a switching center as construction elements in asymmetric synthesis. Discussion on alkylation; Methods used for obtaining chiral auxiliaries in asymmetric synthesis.

关键词： Alcohols   Addition reactions   Enantioselective synthesis   Mixtures   Aromatic compounds  

摘要： A highly enantioselective and practical synthesis of the HIV-1 reverse transcriptase inhibitor efavirenz (1) is described. The synthesis proceeds in 62% overall yield in seven steps from 4-chloroaniline (6) to give efavirenz (1) in excellent chemical and optical purity. A novel, enantioselective addition of Li-cyclopropyl acetylide (4a) top-methoxybenzyl-protected ketoaniline 3a mediated by (1R,2S)-N-pyrrolidinylnorephedrine lithium alkoxide (5a) establishes the stereogenic center in the target with a remarkable level of stereocontrol.

关键词： 左旋氧氟沙星   喹诺酮   不对称合成  

摘要： 以（Ｓ）乳酸乙酯为手性起始原料，经１０步反应合成了抗菌药物左旋氧氟沙星。该方法起始原料丰富易得，反应条件温和，收率好。

关键词： Chirality   Magnetic properties   Molecular structure   Molecules   Enantioselective synthesis  

摘要： Avalos et al focus on the use of external fields to induce absolute asymmetric synthesis, combining theory and experiment.

摘要： Disagrees with a claim made by the author of a study which investigated the seismic behavior of asymmetric-plan systems. Code that must be followed in the design of a building; Implications of the results presented by the research author; Other remarks. INSET: Closure by Rakesh K. Goel.