摘要： 为解决企业在数字化转型过程中面临的数据处理与决策支持难题，本文对大数据分析与决策支持系统（DSS）在企业数字化转型中的应用进行研究，提出了利用大数据分析提升DSS智能化水平、增强决策准确性和优化系统架构等解决方案。大数据分析与决策支持系统的深度融合能够为企业提供精准的决策依据，提高应对复杂市场环境的能力。本文为企业在推进数字化转型过程中如何有效应用大数据分析与DSS提供了理论依据和实践指导，旨在为相关领域的决策者和工程技术人员提供参考。

关键词： 航空公司   运行管理优化   数字孪生  

摘要： 本文根据航空公司智能化转型趋势，提出了航空运输领域的数字孪生系统框架。该框架包括核心资源航权航班、飞机机队和飞行机组运行管理的数字化建模与模拟仿真，通过实时数据采集与历史大数据分析，能够反映出实际运行中航班调度优化、飞机编排和机组排班管理状态变化。通过融合数据驱动的模型和智能算法，数字孪生可以帮助航空公司实现更高效的资源配置，并提供强大的运营优化能力，推动航空公司从人工经验型向智能化的数字化转型。

关键词： Carbapenem resistant Enterobacterales   carbapenemaseproducing Enterobacterales   plasmid   multidrug-resistance   CGS-15943   carbapenemase   adjunctive  

摘要： Carbapenemase producing Enterobacterales (CPEs) represent a group of multidrug resistant pathogens for which few, if any, therapeutics options remain available. CPEs generally harbor plasmids that encode resistance to last resort carbapenems and many other antibiotics. We previously performed a high throughput screen to identify compounds that can disrupt the maintenance and replication of resistance conferring plasmids through use of a synthetic screening plasmid introduced into Escherichia coli K-12 tolC cells. Despite being identified as a potent and selective antiplasmid agent through this screening effort, CGS-15943 was inactive in wild-type E. coli, suggesting that it is susceptible to TolC-mediated efflux. Herein, a series of analogues were developed to confirm the activity of the triazoloquinazoline chemotype and overcome efflux observed in wild-type E. coli K-12. Two analogues demonstrated superior antiplasmid activity to CGS-15943 in E. coli tolC mutants, while one compound displayed moderate activity in wild-type E. coli at low concentrations.

关键词： 大数据技术   财务管理   智慧运营   决策支持系统  

摘要： 本文探讨了大数据在财务管理中的应用,提出并构建了一套结合大数据、数据挖掘和智能决策的财务智慧运营决策支持系统.该系统可实时采集、处理、分析财务数据,提升企业财管效率和决策科学性.通过典型企业应用案例验证,系统成效显著,推动了企业财务管理创新.该研究不仅具有理论价值,还有实际应用意义,展望未来,该系统有望成为财管革新的重要工具.

关键词： 跨境电子商务   政策支持   一带一路   协同发展  

摘要： 随着全球经济一体化进程的加快，跨境电子商务成为国际贸易的重要组成部分。“一带一路”倡议提出以来，各国在政策层面上对跨境电子商务给予了越来越多的支持。本研究通过系统分析相关资料，结合调查和访谈数据，分析跨境电商政策支持与“一带一路”协同发展的问题。研究结果表明，政策支持在推动跨境电子商务基础设施建设、优化通关手续、促进市场开放等方面发挥了显着作用。通过对典型案例的分析，总结政策实施中的经验和教训，提出了政策建议，为未来相关研究和政策制定提供了有价值的参考。

关键词： Livestock  

摘要： Hepatitis E virus (HEV), shared by humans, domestic animals, and wildlife, is an emerging global public health threat. Because wild boars are a major reservoir of HEV, the new zoonotic interfaces resulting from wild boar population increase and synurbization significantly contribute to increasing the risk of zoonotic transmission of HEV. This study characterizes HEV strains of synurbic wild boars and assesses their relationship with sympatric human and domestic swine HEV strains. We analyzed the faeces of 312 synurbic wild boars collected from 2016 to 2021 in the Barcelona Metropolitan Area (BMA), where there is a high density of wild boars, and found 7 HEV-positive samples among those collected between 2019 and 2020. The molecular analysis of these isolates, along with 6 additional wild boar HEV isolates from a previous study, allowed us to establish a close phylogenetic relationship between these HEV strains and human HEV isolates from sympatric blood donors and domestic pigs from Catalonia. HEV-positive wild boar samples belonged to piglet, juvenile and yearling individuals, but not adults, indicating the endemic maintenance of HEV in the wild boar population of the BMA by naïve young individuals. All wild boar HEV isolates in this study classified within HEV genotype 3. The results show, for the first time, a close molecular similarity between the HEV strains endemically maintained by the synurbic wild boars in the BMA and citizens from the same area and period. The data could also indicate that HEV infection presents a seasonal and interannual variability in wild boars of BMA. Further investigation is required to unveil the HEV transmission routes between synurbic wild boars and sympatric citizens. These findings can serve in other synurbic wildlife-human interfaces throughout the world. © 2024 The Authors

摘要： Current plasmid propagation in E. coli compromises large inverted repeats, such as inverted terminal repeats (ITRs) of adeno-associated virus (AAV). Direct long-read sequencing analyses upon varying strains and culture conditions revealed ITR instability caused by a slipped misalignment mechanism, although other mechanism probably contribute. ITRs stabilized in absence of SbcC, which is part of the SbcCD nuclease complex, a human Mre11-Rad50 homolog, or at elevated growth temperatures (e.g. 42 degrees C), with a combination being optimal. Resulting full ITR transgene plasmids improved rAAV yield and purity in HEK-293 productions. The findings advance plasmid biology, cloneable sequences and therapeutic AAV manufacturing.

关键词： 成本效益分析   工程造价优化决策支持系统   设计   数据接口  

摘要： 在工程项目管理中,工程造价优化决策支持系统的设计非常重要,但企业在系统设计过程中常面临一些问题,如数据源整合困难、缺少实时性数据、复杂数据处理能力不足等。为有效应对这些问题,本文对该系统提出了具有针对性的设计策略,包括标准化数据接口、实时更新数据、提高复杂数据处理能力,以进一步提升系统的性能及运行效率,进而为工程项目的成本效益分析提供有效的决策支持。

关键词： 中国石油集团   科技情报研究所   石油工业部   决策支持   中国石油天然气集团有限公司   研究院   国家能源局   试点单位  

摘要： 中国石油集团经济技术研究院(简称“中石油经研院”)是中国石油天然气集团有限公司直属从事战略研究的决策支持机构、首批国家高端智库建设试点单位和国家能源局第一批研究咨询基地,前身是1964年成立的石油工业部科技情报研究所。

关键词： 金融科技   电子商务   数字化转型   技术创新   协同效应  

摘要： 随着数字化转型的深入推进,金融科技(FinTech)与电子商务在现代经济中的作用愈加显著。金融科技利用创新技术如移动支付、区块链和人工智能(AI),正在重塑传统金融服务。同时,电子商务作为新兴商业模式,借助互联网技术实现全球商品和服务交易。本文探讨了金融科技与电子商务的协同效应,分析二者如何通过技术创新和市场模式融合推动业务转型,提升竞争力。研究揭示了这一协同效应对全球经济的影响,包括消费者行为变化、企业运营优化及市场结构演变。此外,本文还讨论了未来的融合趋势和挑战,并提出应对策略。As digital transformation continues to advance, the roles of financial technology (FinTech) and e-commerce in the modern economy have become increasingly significant. FinTech, through the use of innovative technologies such as mobile payments, blockchain, and artificial intelligence (AI), is reshaping traditional financial services. Meanwhile, e-commerce, as an emerging business model, leverages internet technology to enable global transactions of goods and services. This paper explores the synergistic effects between FinTech and e-commerce, analyzing how their integration through technological innovation and market model fusion drives business transformation and enhances competitiveness. The research reveals the impact of this synergy on the global economy, including changes in consumer behavior, optimization of business operations, and the evolution of market structures. Additionally, the paper discusses future trends and challenges in this integration and proposes strategies for addressing them.