关键词： 智能   系统联动   互联网+   在线分析评估   决策支持  

摘要： 当前,云计算、大数据、"互联网+"等革命性技术取得了飞速的发展,为建立智能化水电站奠定了重要的基础。本文介绍了智能化水电厂的内涵、原理和系统组成,从多个实际案例分析、提炼智能化水电站建设中的关键技术和重点技术问题,并提出了解决方案。对促进我国传统水电厂向智能水电厂方向全面发展有一定的参考价值。

关键词： MAUT   TOPSIS   Delphi method   Weight assignment   Multi-attribute decision making   Green building certification   Project team attributes  

摘要： The Green Building (GB) certification process embodies detailed requirements and specifications that lead to additional tasks for project teams, which increases complexity levels of the entire project delivery process. Previous studies show that if the GB certification credits to be fulfilled are selected without considering project team attributes, then elevated levels of time, money, and labor could get wasted while attempting to meet the additional requirements of GB certification. The aim of this study is to develop a multi-attribute decision making (MADM) support tool to be used by GB experts to select the appropriate GB certification credits based on the project team attributes. The developed framework with relative weights assigned via the Delphi method was used to perform the MADM analysis, which employs the hybrid use of the Multi Attribute Utility Technique (MAUT) and the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS). This paper presents the developed MADM tool (i.e., GB-CS tool) and the relative weights of the attributes that were determined following expert opinions. To validate the tool, a case study was conducted at a LEED-registered residential project. The results show that the GB-CS Tool was successful in ranking the GB certification credits to be selected. This hybrid MADM tool can be used for preventing disruptions and bottlenecks in GB project delivery processes by assisting the owners/GB consultants in effectively selecting suitable GB certification credits based on the project team attributes. Thus, with the assistance of the GB-CS tool, root causes of waste can be mitigated in the GB project delivery process, decreasing associated hidden costs. (C) 2017 Elsevier Ltd. All rights reserved.

关键词： Dextran Sulfate   Cecum   Unpolished rice   Dextran Sulfate Sodium   waveform recording   Meals   bromine   Inflammatory Response   Colon  

摘要： The present study was aimed to investigate the impacts of brown rice (BR) and retrograded brown rice (R-BR) consumption on colonic health and gut microbiota in dextran sulfate sodium (DSS) induced colitis mice. Thirty two female C57Bl/6Mlac mice were fed with modified AIN 93G diets by replacing cornstarch in the original composition with white rice (WR), BR and R-BR powder. The mice were divided into 4 groups and fed with the following experimental diets for 4 weeks: (1) negative control (WR: diet with WR), (2) positive control (DSS_WR: DSS and diet with WR), (3) DSS_BR: DSS and diet with BR, and (4) DSS_R-BR: DSS and diet with R-BR. BR and R-BR had a greater content of fat, dietary fiber, GABA, gamma-oryzanol, gamma-tocotrienol, ferulic acid and p-coumaric acid than WR (p < 0.05). No significant difference in the level of these bioactive compounds was noted between BR and R-BR. Nevertheless, R-BR had a 1.8 fold resistant starch (RS) content of BR (p < 0.05). The DSS_BR and DSS_R-BR groups showed a lower ratio of colonic weight to length, and a lower content of iNOS, COX-2, MPO, IL-6 and INF-gamma in colonic homogenates than the DSS_WR group. However, the DSS treated mice fed with the R-BR diet had significantly milder histopathological inflammatory injury and lower colonic iNOS expression than the DSS_BR and DSS_WR groups. The percentage of mesenteric regulatory T cells significantly increased in the DSS_R-BR group compared to that in the DSS_WR group. The DSS treated mice fed with the R-BR diet showed a significant increase in cecal bacterial diversity and abundance of genera Prevotella, Ruminococcus, Dorea, Coprococcus and Dehalobacterium but a significant decrease in pathogenic bacteria including Bacteroides and Enterococcus compared to the DSS_WR group. Thus, the present data indicate that BR and R-BR ameliorate colonic inflammation in experimental colitis induced by DSS in mice by suppressing inflammatory mediators and modulating regulatory T cell responses as

关键词： Oxymatrine   PI3K/AKT pathway   Inflammation   Apoptosis   Immunity   Ulcerative colitis  

摘要： Oxymatrine (OMT), an alkaloid derived from the root of the Sophora flavescens, has been reported to possess a significant effect on relieving UC owing to its anti-inflammatory property. But the other therapeutic mechanism of OMT remains unclear. Recent studies have found, PI3K/AKT signaling pathway is involved in the pathogenesis of UC by pro-inflammatory effects and activating T cells. Moreover, PI3K/AKT pathway is one of the most important pathways for regulating cell apoptosis. Thus, we aim to explore whether OMT protects against UC by targeting PI3K/AKT pathway. We established the UC mice models, using LY294002 (a specific inhibitor of PI3K/AKT) as a positive control, to observe the effect of low, medium and high dose of OMT on UC and its influence on PI3K/AKT signaling pathway. Our data indicated that OMT can significantly ameliorate UC through anti-inflammatory, pro-apoptotic, down-regulating the differentiation of Th1 and Th17 cells via PI3K/AKT pathway. This study reveals that PI3K/AKT signaling pathway is a potential mechanism of OMT-induced UC remission and suggests that OMT is a promising therapeutic agent for the treatment of UC.

关键词： multi-attribute decision-making   reinsurance   proportional reinsurance   non-proportional reinsurance   TOPSIS  

摘要： This article addresses the possibility of incorporating intelligent decision support systems into reinsurance decision-making. This involves the insurance company and the reinsurance company, and is negotiated through reinsurance intermediaries. The article proposes a decision flow to model the reinsurance design and selection process. This article focuses on adopting more than one optimality criteria under a more generic combinational design of commonly used reinsurance products, i.e., proportional reinsurance and stop-loss reinsurance. In terms of methodology, the significant contribution of the study the incorporation of the well-established decision analysis tool multiple-attribute decision-making (MADM) into the modelling of reinsurance selection. To illustrate the feasibility of incorporating intelligent decision supporting systems in the reinsurance market, the study includes a numerical case study using the simulation software @Risk in modeling insurance claims, as well as programming in MATLAB to realize MADM. A list of managerial implications could be drawn from the case study results. Most importantly, when choosing the most appropriate type of reinsurance, insurance companies should base their decisions on multiple measurements instead of single-criteria decision-making models so that their decisions may be more robust.

关键词： intelligent sensor   e-maintenance   microcontroller   MEMS   machine learning  

摘要： Microelectromechanical systems (MEMS)-based sensing networks with on-board signal processing capabilities are becoming very attractive for monitoring the condition of rotating and static equipment. Their advantages in cost and size are an important factor for deployment in a new generation of maintenance called e-maintenance. In this paper, an intelligent monitoring system for e-maintenance (IMSEM) was developed using MEMS accelerometers, a low-power microprocessor and a wireless communication module. The system has a compatible framework and interface with open system architecture for condition-based maintenance (OSA-CBM). It integrates OSA-CBM-defined functions, including a sensing module, signal processing, condition monitoring and health assessment. Thus, the developed system successfully reduced the monitoring complexity and communication overhead with human operators. The performance of IMSEM is evaluated by carrying out fault diagnostics on the rotating unbalance of a mechanical shaft driven by a direct current (DC) motor with varying load and speed. Five statistical features were calculated for 63 vibration datasets. 25 datasets were used to train a support vector machine, with a linear kernel, and the other 38 sets were used for binary classification. About 94.7% of unknown conditions were successfully classified as healthy/unhealthy based on all features, which was improved to 100% using the best three features. This has demonstrated the capability of the developed system in detecting faults and the severity of rotor unbalance, based on ISO 1940-1:2003.

关键词： Carob leaves   OFI-Cladodes   Aqueous extract   Swiss mice   HFD obesity   DSS colitis   Inflammation  

摘要： In the present study, we have investigated the effects of polyphenol-rich infusions from carob leaves and OFI-cladodes on inflammation associated with obesity and dextran sulfate sodium (DSS)-induced ulcerative colitis in Swiss mice. In vitro studies revealed that aqueous extracts of carob leaves and OFI-cladodes exhibited anti-inflammatory properties marked by the inhibition of IL-6, TNF-alpha and nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells concomitant with NF-kappa beta nucleus translocation inhibition. For in vivo investigations, Swiss male mice were subjected to control or high fat diet (HFD). At the 8th week after the start of study, animals received or not 1% infusion of either carob leaves or OFI-cladode for 4 weeks and were subjected to 2% DSS administration in drinking water over last 7 days. After sacrifice, pro-inflammatory cytokines levels in plasma and their mRNA expression in different organs were determined. Results showed that carob leaf and OFI-cladode infusions reduced inflammation severity associated with HFD-induced obesity and DSS-induced acute colitis indicated by decrease in pro-inflammatory cytokines expression (as such TNF-alpha, IL1b and IL-6) in colon, adipose tissue and spleen. In addition, plasma levels of IL-6 and TNF-alpha were also curtailed in response to infusions treatment. Thus, carob leaf and OFI-cladode infusions prevented intestinal permeability through the restoration of tight junction proteins (Zo1, occludins) and immune homeostasis. Hence, the anti-inflammatory effect of carob leaves and OFI-cladodes could be attributed to their polyphenols which might alleviate inflammation severity associated with obesity and colitis.

关键词： Compound edaravone injection (C.EDA)   Colitis   M2 macrophage polarization   Arg-1   IL-10   JAK2-STAT3 signaling  

摘要： Compound edaravone injection (***), a compound preparation composed of edaravone (EDA) and (+)-Borneol with the mass ratio of 4: 1, displays a better anti-inflammatory activity than EDA. However, its precise mechanism remains to be further studied. In this work, we investigated whether (+)-Borneol could improve the efficacy of EDA against DSS-induced colitis. We found that *** at 7.5 and 15 mg/kg could significantly relieve the disease activity index (DAI) and reduce the loss of body weight and colon length in a dose-dependent manner, while EDA or (+)-Borneol alone only had moderate effects even at the highest dose. Additionally, ELISA revealed that *** could more dramatically decrease the protein levels of inflammatory cytokines and increase the levels of anti-inflammatory cytokine than EDA or (+)-Borneol alone both in colon tissues and serum. H&E staining and IHC assay also indicated that *** exhibited more prominent effects on increasing the population of M2 macrophages, decreasing M1 macrophages infiltration and protecting intestinal barrier integrity. Furthermore, in vitro studied demonstrated that ***, EDA or (+)-Borneol failed in inhibiting M1 macrophages activation but could specifically induce the activation of M2 macrophages in a STAT3-dependent manner. Knockdown the expression of STAT3 successfully abolished the effect of *** and EDA on promoting M2 macrophages activation. Consistent with in vivo study, *** exhibited a more efficient ability of inducing M2 macrophages polarization and STAT3 activation than EDA or (+)-Borneol alone in vitro. In conclusion, we confirmed that (+)-Borneol improved the efficacy of EDA against DSS-induced colitis by promoting M2 macrophages polarization via JAK2-STAT3 signaling pathway.

摘要： International attention towards energy efficiency improvement is growing, pressuring the built environment to become more sustainable. Part of this energy efficiency improvement must be achieved at Dutch pri- mary school buildings, but insufficient- and separation of budgets complicate the development of sustain- able school buildings. Subject to this financial pressure, the current poor state of primary school buildings in terms of indoor environmental quality is, and will remain insufficient. Affecting performance, productivity and health of students and staff, and additionally having a monetary impact on school boards. The inability to achieve energy efficiency in combination with good indoor environmental quality, within the available financial means, is for a large part explained by a lack of knowledge and experience in building- renovation by many Dutch school boards. Often, indoor environmental quality is one of the first things to suffer from insufficient funds. A decision-making framework is developed to provide school boards with the necessary knowledge and insight to better finance and organize renovation projects, providing more (finan- cial) room to address the indoor environmental quality of their school buildings. Leading to more balanced school buildings in terms of People (indoor environmental quality), Planet (energy efficiency), and Profit (costs). This framework comprises of a decision flowchart, supplemented by sustainable measure packages, that facilitates school boards in the renovation decision making process. The flowchart provides school boards insight in the decision-making process, (technical, financial and organizational) renovation opportunities, and effects of-, and on-, indoor environmental quality. This flowchart is developed using desk research, qual- itative interviews and expert meetings. Then tested by obtaining qualitative expectations in interviews with school boards and a focus group with financial experts. The expectations ar

摘要： The current deuteron beam polarimetry at Nuclotron is provided by the Internal Target polarimeter based on the use of the asymmetry in dp- elastic scattering at large angles in the cms at 270 MeV. The upgraded deuteron beam polarimeter has been used obtain the vector and tensor polarization during 2016/2017 runs for the DSS experimental program. The polarimeter has been used also for tuning of the polarized ion source parameters for 6 different spin modes.