关键词： 引水工程   安全决策支持系统  

摘要： 引水工程建设主要用于解决区域间水资源空间及时间分布不均匀的问题,具有工程路线长、地域范围广、地形条件复杂、涉水建筑物及设施多等特点。传统的水利工程安全工作多针对单个水工构建物或设施,但对于引水工程整体输水安全的关注还不够,亟待研究和开发引水工程安全决策支持系统。本文从整体角度研究并设计了引水工程安全决策支持系统的数据流程及系统架构,并深入分析了其主要实现技术,为安全评估与决策支持自动化、一体化运行奠定了基础。

关键词： 治理   经营管理   商业银行   业务流程   决策支持   风险控制   产品定价   决策过程  

摘要： 商业银行在经营管理活动中积累了大量数据，这些数据除了支撑银行前台业务流程运转之外，越来越多地被用于决策支持、风险控制、产品定价、绩效考核等管理决策过程。如果不能对这些数据进行有效管理，矮价值不仪不能得到利用，还会成为企业运营沉重的包袱。

关键词： 水环境   决策支持系统   系统集成   调控   北运河   水污染治理  

摘要： 以建立水环境实时调控决策支持系统为目标,集成综合数据监测体系、数据库、流域入河污染物负荷模型、河流水环境模型、水环境承载能力与污染负荷动态调控模型、GIS平台等众多模块,提出了系统组成的总体框架,分析了多种数学模型间的集成链接方法、GIS显示体系与数学模型间的交互方法、水环境状态实时模拟与基于调控措施的方案模拟等系统集成的关键环节,提出了水环境实时调控与数字化管理功能在复杂大系统中的实现思路与方法,为复杂水环境调控系统的开发与集成提供了简单实用的集成模式。系统在北运河水系水环境管理中的应用结果表明:该系统方法实现了北运河的实时调控模拟,提高了区域水环境管理的智能化水平。研究成果对水环境实时调控与决策系统的建立及精细化管理具有重要的参考价值。

关键词： 舆情分析   决策支持   大数据技术   Hadoop   系统架构  

摘要： 大数据背景下,传统的舆情分析技术和监控系统很难适应海量舆情信息的大数据特征。构建了基于大数据技术的舆情分析与决策支持系统的分层架构,并详细介绍了系统中所使用的关键技术。大数据给社会舆情分析与政府决策支持带来了新的机遇,基于大数据技术的舆情分析与决策支持系统为决策者应对舆情危机提供了科学化的信息支持。

关键词： 流域水生态功能管理区   水生态系统   管理决策   流域水资源  

摘要： 应用ArcGIS Engine10.1开发工具包,在Visual Studio 2010开发环境下,完成了流域水生态功能管理区决策支持系统的设计与开发。该系统将流域水生态功能管理区划分成联合管理、独立管理和委托管理等子单元;并通过对子单元的水生态系统健康进行评价,将子单元的水生态系统受损程度分为好、中、差3类,以差异化的水环境管理方法为流域水生态功能管理决策和实施提供支持,有助于流域管理主体建立基于水生态功能的水质目标管理体系。

关键词： 图书馆   决策支持   信息服务  

摘要： 近年来图书馆面对时代的变化,积极探索服务转型,在信息服务方面产生了新的生长点。本文介绍了华东师范大学图书馆开展决策咨询服务的实践成果,采集专任教师的学术成果,整合职能部门采集的课程、项目、获奖数据,以多部门联合项目组的形式构建了绩效数据库平台,以网页查询的方式向教师个人、院系管理员、校级管理员分权限呈现相关数据及统计报告。

关键词： Azoxymethane   Boswellia Serrata   Colorectal cancer   Dextran sulfate sodium   Inflammation  

摘要： Scope: Boswellia serrata (BS) resin is a popular dietary supplement for joint nourishment. In this study, we investigated the chemopreventive effects of dietary BS extract and its impact of gut microbiota on azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated colon cancer in mice. Methods and results: Male ICR mice were injected with AOM and 2% DSS via drinking water. The mice were fed with 0.25 or 0.5% BS extract, and colonic tissue were collected at 15 weeks. The main effective components of BS supercritical CO2 extraction were analyzed by LC-MS/MS are boswellic acids. We found that treatment with BS extract significantly reduce the colonic tumor formation. Western blot and histological analysis revealed that dietary BS extract could markedly reduce the inflammation associated protein levels expression. Furthermore, BS extract reduced cell proliferation via inhibiting phosphorylation level of protein kinase B (Akt), glycogen synthase kinase 3 beta (GSK3 beta), and downregulation of cyclin D1. In addition, BS extract also altered the composition of gut microbiota by enhancing the proportion of Clostridiales and reducing the percentage of Bacteroidales. Conclusion: In summary, BS extract decreased the protein levels of inflammative enzymes such as inducible nitric oxide synthase and cyclooxygenase-2 in colonic mucosa. It also mediated Akt/GSK3 beta/cyclin D1 signaling pathway and altered the composition of gut microbiota to alleviate tumor growth. Taken together, this study suggests that BS extract has great potential to suppress colon tumorigenesis.

关键词： Ginsenoside Rg1   NLRP12   Colitis  

摘要： Ginsenoside Rg1 is a major active constituent of Panax ginseng and possesses anti-inflammatory effects. It has been reported to have therapeutic effects on various diseases. In the present study, we investigated the role of ginsenoside Rg1 in dextran sodium sulfate (DSS)-induced mouse colitis. Our results showed that ginsenoside Rgl markedly reduces proinflammatory cytokines release upon DSS stimulation of mouse dendritic cells, that ginsenoside Rg1 suppresses IL-1 beta (Interleukin 1 beta) and TNF-alpha (Tumor necrosis factor alpha) release via up regulation of NLRP12 (NACHT, LRR and PYD domains-containing protein 12) expression, and that ginsenoside Rgl significantly decreases the inflammatory response to DSS-induced mouse colitis, as evidenced by increased body weight, reduced colonic damage scores and disease activity index (DAI), and lowered proinflammatory cytokines levels. These results highlight the potential therapeutic use of ginsenoside Rgl as an anti-inflammatory agent in the treatment of colitis.

关键词： AHP model   criteria hierarchy   expert estimation   multicriteria decision making   resource allocation   strategy  

摘要： This paper outlines an approach to strategic planning, based on decision-making support methods. It provides a description of a step-by-step procedure, allowing the decision maker to build a strategy, targeted at solution of some weakly structured problem or at achievement of some complex goal, influenced by multiple tangible and intangible criteria. Criteria are formulated by experts and arranged into a hierarchy, as prescribed by the analytic hierarchy process. Relative weights of criteria are calculated on the basis of expert estimates, using the combinatorial approach, which is, in a way, an extension of analytic hierarchy process toolkit. In the context of this paper, a strategy is defined as the optimal way of currently available resource distribution among specific factors or projects, which influence the main goal of a strategic plan. Each project is characterized by certain funding volume constraints (minimum and maximum resource amounts) as well as time frames (launching and completion or termination dates). As an example of implementation of our approach, we consider a case of resource distribution among environmental projects.

关键词： Sinomenine   Chitosan   Colitis   Inflammatory bowel disease   Toll-like receptors  

摘要： Sinomenine is a pure alkaloid with immunosuppressive effects that is extracted from the Chinese medicinal plant Sinomenium acutum. We studied the therapeutic effects of sinomenine on inflammatory bowel disease. In this study, we randomly divided mice into the following ten groups: Control group;DSS-induced colitis group;Salicylazosulfapyridine (SASP)-treated group;Chitosan-treated group;low-, medium-, and high-dose sinomenine-treated and sinomenine enteric-coated microspheres-treated groups. We recorded changes in colon length, disease activity index (DAD, and colon pathology, measured TLR4, MyD88, SIGIRR, NF-kappa B p65 protein levels and inflammatory serum cytokine levels. Except for the Control group, the weight of mice in each group decreased, the DAI of the DSS-induced colitis group was significantly higher than the other groups, and the DAIs of the sinomenine- and sinomenine enteric coated microspheres-treated groups were significantly lower than that of the SASP-treated group. TLR4, MyD88, NF-kappa B p65 and proinflammatory cytokine expressions decreased dose dependently in the sinomenine and sinomenine enteric-coated microspheres-treated groups and were generally lower in the sinomenine enteric coated microspheres groups. However, SIGIRR and anti-inflammatory IL-10 expressions exhibited the opposite pattern. Based on the superior therapeutic effect, sinomenine enteric-coated microspheres might regulate TLR/NF-kappa B signaling and would be beneficial for an effective and safe therapy of inflammatory bowel disease.