关键词： 京津冀   电子商务   立法协同  

摘要： 目前,我国京津冀电子商务立法协同尚存在一系列体制机制等瓶颈制约,迫切需要制定京津冀协同发展法,加强中央顶层设计,完善京津冀电子商务立法规划、提案、审议、通过、交叉备案、交流等程序协同机制,健全京津冀电子商务具体制度体系,建立完善立法后评估机制,为京津冀协同发展战略实施提供法治保障。

关键词： 农业管理   决策支持系统   研制开发   发展对策  

摘要： 随着我国科技水平的不断发展,农业的发展逐渐受到人们的重视,其也在不断地完善中。农业管理决策支持系统广泛应用到了农业的各个领域中。但是,目前我国的农业管理决策支持系统在研制上还存在着一定的不足。本文将进一步对农业管理决策支持系统的研制、开发进行分析、探讨未来的发展对策。

关键词： Chemical activation  

摘要： Although Aster glehni has been reported to prevent diabetes mellitus, hypercholesterolemia, insomnia, and cardiovascular disease, the anti-inflammatory effect of Aster glehni in colonic tissue remains unclear. In this study, we investigated the anti-inflammatory effects and the underlying molecular mechanism of an ethanol extract of Aster glehni (AG) in mice with dextran sulfate sodium (DSS)-induced colitis. AG significantly attenuated DSS-induced DAI scores, which implied that it suppressed diarrhea, gross bleeding, and the infiltration of immune cells. AG administration also effectively prevented shortening of the colon length and enlargement of the spleen size. Histological examinations indicated that AG suppressed colonic damage and the thickness of the muscle layer induced by DSS. In addition, AG inhibited the production of pro-inflammatory cytokines, such as TNF-alpha, IL-1 beta, and IL-6, and the protein expression of COX-2 and iNOS in mice with DSS-induced colitis. Administration with AG suppressed the activation of nuclear factor-.B (NF-kappa B) including the nuclear translocation of the p65 NF-kappa B subunit, phosphorylation and degradation of I kappa B-alpha Taken together, these findings suggest that the anti-inflammatory effects of AG are mainly related to the inhibition of the expressions of inflammatory mediators via NF-kappa B inactivation, and support its possible therapeutic application in colitis.

关键词： autophagy   MEK/ERK pathway   p62/SQSTM1   radiation, E1A+cHA-RAS transformants  

摘要： Autophagy is a conserved process of protein and organelle degradation that serves to maintain cell viability. Autophagy is frequently induced in response to stress or to exposure to DNA-damaging agents or retinoids, as well as to starvation and deficiency of growth factors. In this work, autophagy induced in E1A+cHA-RAS transformed cells in response to X-ray radiation was studied, with a focus on the role of the MEK/ERK signaling pathway in the regulation of radiation-induced autophagy. It was found that inhibition of the MEK/ERK pathway diminished cell viability and altered the sequence of events in radiation-induced autophagy. In particular, it caused aberrations in its final stages, leading to cytoplasmic accumulation of the p62/SQSTM1 adaptor protein in autophagic cavities of unclear origin. Thus, the MEK/ERK pathway activity is essential for the induction and maintenance of autophagy, increasing the viability of exposed cells in response to radiation. © 2017, Pleiades Publishing, Ltd.

关键词： 农民致富   信息咨询   翅膀   公益服务   农业发展   工作人员   投诉举报   决策支持  

摘要： 公益服务专用号码,也是那一年,我从大学毕业并光荣的成为了一名服务基层的大学生村官.从那时起,我从一名服务农业的基层工作人员的视角见证了12316服务热线如何为农业发展和农民致富插上了信息的翅膀,在涉农信息咨询、假劣农资投诉举报、舆情监测、领导决策支持等方面发挥着越来越重要的作用.从2006年到2016年在历史长河中是短短的十年,但对于我却是步入社会不断成长的十年,对于12316公益服务热线是具有重要发展历程的十年.十年间,在“12316”的陪伴下,我成长为一名懂农业、爱农民、具有丰富的工作经验的乡镇干部,12316公益服务热线也成为了百姓口中的＂致富号＂和＂万事通＂.

关键词： 智能采油系统   决策参数   动态模型   偏好多目标优化  

摘要： 通过智能采油系统自主分析与决策获取油田机采过程最佳决策参数,对解决机采系统效率低、能耗大等问题具有重要意义。受机械、地层、人为等不确定因素影响,智能采油系统难以构建生产参数、环境变量与系统性能、设定生产方式之间的机理关系并优化决策。为此,提出基于动态演化建模的偏好多目标优化方法,以实现采油系统的自主决策。利用无迹卡尔曼滤波神经网络(Unscented Kalman filter neural network,UKFNN)挖掘机采系统潜在规律,建立其动态模型;构建产液量偏好多目标优化目标函数,并利用非改进支配排序遗传算法(Non-dominated sorting genetic algorithm 2,NSGA2)获取相应的最佳决策参数。某油田试验结果表明:该方法使得系统日耗电量降低15.87%,系统效率提高4.9%。可见,所提方法可行且有效。

关键词： 风险分析   文件   Marine   决策支持   Log  

摘要： 据《Marine Log》5月2日报道，DNVGL发布一份立场文件（position paper），讨论如何用动态的方法进行风险分析，从而为船舶运营提供改进的、实时的决策支持。

关键词： 高职   电子商务   网站建设管理与维护   理实一体化  

摘要： 高职电子商务专业的计算机类课程有其自身的特点,因而在教学模式方面异于本科教学,也和高职软件类专业不同,这是与其专业性质相关的。理实一体化教学模式,被认为是计算机类课程在电子商务专业中行之有效的教学模式。网站建设、管理与维护作为电子商务专业的实践课程,有必要设计出一种符合自身特点的教学模式,这是相关课程理实一体化实践的一种有效尝试。

关键词： 电子商务  

ISBN: (纸本)9787568029872

摘要： 本书将生态学与信息生态学的理论和方法引入电子商务研究领域, 开展电子商务信息生态链的研究, 从协同竞争机制入手, 力求从内涵外延、影响因素、具体作用、博弈模型四个方面揭示电子商务信息生态链协同竞争机制, 构建一个相对完善的电子商务信息生态链协同竞争机制的研究体系。

关键词： AAA(+) proteins   LonA proteases   ATP-dependent proteolysis   role of N-terminal region  

摘要： The truncated form of E. coli LonA protease (EcLon) lacking the N-terminal fragment 1-172 (Lon173) and the variant with deleted coiled-coil (CC) fragment 173-283 (dCC-Lon, a deletion form) are produced and characterized to study the role of the N-terminal region in the functioning of this protease. A comparative analysis of the properties of full-length EcLon protease, dCC-Lon, and Lon173 as well as an earlier produced form with retained C-terminal region (235-280) of CC fragment, Lon235, is performed. As is shown, fragment 1-280 plays an important role in both formation of the ATPase site and maintenance of a stable EcLon protease conformation. Fragment 107-172 is of a paramount importance for implementation of the processive mechanism of ATP-dependent proteolysis.