关键词： “一带一路”倡议   中医药海外推广   高层次商务人才培养   跨学科  

摘要： 单学科的人才培养模式导致人才在知识结构上存在重大缺陷。在"一带一路"战略下,中医药高等院校必须深刻把握人才培养的跨学科要求,革新人才培养机制,拓宽人才培养口径,打破学科壁垒,探索构建中医药海外推广高层次商务人才的跨学科协同培养平台。并以平台为落脚点,进行跨学科复合型的中医药海外推广商务课程、教材及师资队伍的建设和改革。通过资源的合理配置,选拔优秀人才进行跨学科式的培养,为中医药海外推广储备充足的高层次商务人才。

摘要： 65.6

关键词： 物资管理工作   航天型号   决策支持系统   设计   规避风险   复杂工程   支撑作用   供应链  

摘要： 航天型号作为大型复杂工程，其供应链涉及环节多，协作企业多，在航天型号物资配套过程中，风险是客观存在的。要做到确保型号物资的质量、进度和成本要求，最根本的手段就是要最大程度地定义、监控和规避风险。而实际上航天供应链型号物资数据分散在各个企业，需要将这些数据有效的集中起来，实现实时检查、监控变化、挖掘规律，从而对航天物资管理工作起到更好的支撑作用。

关键词： 智能调度   决策支持   信息   系统  

摘要： 本文从全面提高安全播出水平的角度出发,提出一套智能化综合值守和研判决策系统的功能设计方案,并详细介绍了广播电视监管智能调度与决策支持信息系统总体架构和功能设计,分析了关键技术及技术实现路线。该系统可为广播电视安全播出调度指挥提供有效的决策支撑和研判依据。

摘要： ObjectiveMaternal high-fat diet (HFD) may alter the offspring intestinal immune system, thereby enhancing susceptibility toward inflammatory bowel disease. The objective of the current study was to investigate the impact of maternal HFD on offspring intestinal health using a mouse model of dextran sulfate sodium (DSS)-induced colitis. MethodsDams were provided with either HFD (60%) or control diet. After weaning, female offspring from both groups were kept on 45% HFD. At 14 weeks of age, offspring were subjected to 2.5% DSS in drinking water for 5 days, followed by 5 days of recovery. ResultsOffspring from maternal HFD had higher body weight gain before DSS induction and had higher liver and fat weights with increased adipocyte size at necropsy. When subjected to DSS treatment, HFD offspring had accelerated body weight loss and exaggerated disease activity index. HFD offspring had an elevated histopathological score and interleukin (IL)-1, IL-6, and IL-17 expression with upregulated NF-B signaling. Maternal HFD resulted in enhanced neutrophil infiltration associated with elevated expression of monocyte chemoattractant protein-1. Furthermore, maternal HFD suppressed AMP-activated protein kinase activity and decreased sirtuin 1 and p53 protein contents in offspring gut. ConclusionsMaternal HFD consumption predisposes offspring to a higher susceptibility to develop inflammatory bowel disease.

关键词： high-fat diet   colitis   green pea   inflammation   mucin 2   endoplasmic reticulum stress  

摘要： Obesity is a risk factor for developing inflammatory bowel disease. Pea is unique with its high content of dietary fiber, polyphenolics, and glycoproteins, all of which are known to be health beneficial. We aimed to investigate the impact of green pea (GP) supplementation on the susceptibility of high-fat diet (HFD)-fed mice to dextran sulfate sodium (DSS)-induced colitis. Six-week-old C57BL/6J female mice were fed a 45% HFD or HFD supplemented with 10% GP. After 7-week dietary supplementation, colitis was induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period. GP supplementation ameliorated the disease activity index score in HFD-fed mice during the recovery stage, and reduced neutrophil infiltration, mRNA expression of monocyte chemoattractant protein-1 (MCP-1) and inflammatory markers interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-gamma (IFN-gamma), and inducible nitric oxide synthase (iNOS) in HFD-fed mice. Further, GP supplementation increased mucin 2 content and mRNA expression of goblet cell differentiation markers including Trefoil factor 3 (Tff3), Kruppel-like factor 4 (Klf4), and SAM pointed domain ETS factor 1 (Spdef1) in HFD-fed mice. In addition, GP ameliorated endoplasmic reticulum (ER) stress as indicated by the reduced expression of Activating transcription factor-6 (ATF-6) protein and its target genes chaperone protein glucose-regulated protein 78 (Grp78), the CCAAT-enhancer-binding protein homologous protein (CHOP), the ER degradation-enhancing ff-mannosidase-like 1 protein (Edem1), and the X-box binding protein 1 (Xbp1) in HFD-fed mice. In conclusion, GP supplementation ameliorated the severity of DSS-induced colitis in HFD-fed mice, which was associated with the suppression of inflammation, mucin depletion, and ER stress in the colon.

摘要： Fuzzy logic has been applied successfully for fixed control systems and extensive research exists on its use. However, recent advances in silicon technology allow for the development of more sophisticated and reconfigurable control systems and there is a gap in the literature for reconfigurable fuzzy logic controllers deployed on embedded micro-controllers. The goal of this thesis is to create a proof of concept fuzzy logic control software, capable of remote reconfigurability. To provide generic requirements for the software concept, a scenario based analysis was performed of two domains, namely building automation and horticulture. The resulting Smart Space Engine is a flexible fuzzy logic control software concept, which has no fixed rule logic and can be remotely reconfigured at runtime. The system has a generic event driven architecture applicable to multiple domains. The proof of concept implementation has been evaluated using scenarios from the target domains. This preliminary evaluation indicates that fuzzy logic can be effectively used for a flexible and reconfigurable control software that can be deployed to embedded systems. The Smart Space Engine can also be deployed to multiple platforms such as Windows, Linux and OSx.

关键词： Co-simulation   Mechatronic systems   Embedded control  

摘要： The large majority of technological devices can be seen as the sum of components of heterogeneous nature (electrical, mechanical, thermal, software, etc.) so that their analysis and design calls for the use of tools from different engineering disciplines. Integration among the different tools is particularly relevant at control system design level, since it is at this stage that it is required to analyze the behavior of both each single component and the system as a whole, with different levels of detail. In this paper mechatronic systems are considered, that exhibit a strong interplay between mechanical and electrical components, and the issue of modeling and designing embedded control algorithms and architectures for such systems is addressed. In particular, an integrated virtual prototyping approach for analyzing the system behavior down to embedded software level is proposed, that can be used in a wide number of situations that can represent the actual real-world operational conditions of consumer products. This approach can be used for system design (in particular at control systems level), embedded software design, and virtual testing so as to optimize and reduce the costs of late stage software development, physical prototypes, and their testing. The case study is based on some recently derived software tools that perform the co-simulation of the firmware execution and the multi-physical controlled system dynamics. The actual control software implemented in the final product can be entirely developed and tested inside the virtual prototype. To prove the validity and potentialities of the proposed approach, a real case study is presented, regarding a very common, though complex to simulate, mechatronic system such as an electric sliding gate. It turns out that the proposed environment goes beyond hardware-in-the-loop tools, since it does not require the use of specific hardware (the hardware itself is simulated in detail) but allows to analyze in detail the st

关键词： Inflammation   Sphingosine 1-Phosphate   Sphingosine Kinase   Sphingolipids   Inflammatory Bowel Disease  

摘要： Sphingosine-l-phosphate (SIP) is a biologically active sphingolipid metabolite which has been implicated in many diseases including cancer and inflammatory diseases. Recently, sphingosine kinase 1 (SK1), one of the isozymes which generates SIT, has been implicated in the development and progression of inflammatory bowel disease (IBD). Based on our previous work, we set out to determine the efficacy of a novel SK1 selective inhibitor, LCL351, in a murine model of IBD. LCL351 selectively inhibits SKI. both in vitro and in cells. LCL351, which accumulates in relevant tissues such as colon, did not have any adverse side effects in vivo. In mice challenged with dextran sodium sulfate (DSS), a murine model for IBD, LCL351 treatment protected from blood loss and splenomegaly. Additionally, LCL351 treatment reduced the expression of pro-inflammatory markers, and reduced neutrophil infiltration in colon tissue. Our results suggest inflammation associated with IBD can be targeted pharmacologically through the inhibition and degradation of SK1. Furthermore, our data also identifies desirable properties of SK1 inhibitors.

摘要： In recent years, a need for product traceability in the cold supply chain has emerged. The purpose of this study was to identify and map out different kinds of identification technologies and techniques used for cold supply chain traceability. This was done by looking into what traceability solutions are available right now through literature review. The results from this review were then further analyzed to obtain a basis for the current state of knowledge, technical solutions and to identify possible traceability structures in the cold chain. A decision support framework was constructed for choosing a suitable technical solution. It consists of a table listing different functions and attributes of technologies and a decision-tree. The decision support framework created from this work will help the user to identify what kind of traceability technology and structure best suits his products. This is important, as it can often be difficult for the user to decide which technology is most beneficial for his company. That is why this decision support framework will enable him to decide what is technologically feasible, practical, economical, can sustain reputation, quality and safety of the products.