关键词： Anatomy   Animal cells   Animal models   Biochemistry   Biological tissue   Biology and life sciences   Cell biology   Cellular types   Colitis   Collagens   Colon   Connective tissue   Connective tissue cells   Developmental biology   Digestive system   Experimental organism systems   Fibroblasts   Fibrosis   Gastroenterology and hepatology   Gastrointestinal tract   Histochemistry and cytochemistry techniques   Immunohistochemical analysis   Immunohistochemistry techniques   Immunologic techniques   Inflammatory bowel disease   Medicine and health sciences   Model organisms   Mouse models   Proteins   Research and analysis methods   Research Article  

摘要： Background Intestinal fibrosis is characterized by abnormal production and deposition of extracellular matrix (ECM) proteins by activated myofibroblasts. The main progenitor cells of activated myofibroblasts are the fibroblasts and the epithelial cells, the latter through the epithelial-mesenchymal transition (EMT). Aim To evaluate the action of the new PPAR-gamma modulator, GED-0507-34 Levo (GED) on the expression of EMT associated and regulatory proteins such as TGF-beta, Smad3, E-cadherin, Snail, ZEB1, beta-catenin, and GSK-3 beta, in a mouse model of DSS-induced intestinal fibrosis. Methods Chronic colitis and fibrosis were induced by oral administration of 2.5% DSS (w/v) for 6 weeks. GW9662 (GW), a selective PPAR-gamma inhibitor, was also administered by intraperitoneal injection at the dose of 1 mg/kg/day combined with GED treatment. All drugs were administered at the beginning of the second cycle of DSS (day 12). 65 mice were randomly divided into five groups (H2O as controls n = 10, H2O+GED n = 10, DSS n = 15, DSS+GED n = 15, DSS+GED+GW n = 15). The colon was excised for macroscopic examination and histological and morphometric analyses. The level of expression of molecules involved in EMT and fibrosis, like TGF-beta, Smad3, E-cadherin, Snail, ZEB1, beta-catenin, GSK-3 beta and PPAR-gamma, was assessed by immunohistochemistry, immunofluorescence, western blot and Real Time PCR. Results GED improved the DSS-induced chronic colitis and fibrosis. GED was able to reduce the expression of the main fibrosis markers (alpha-SMA, collagen I-III and fibronectin) as well as the pivotal pro-fibrotic molecules IL-13, TGF-beta and Smad3, while it increased the anti-fibrotic PPAR-gamma. All these GED effects were nullified by co-administration of GW with GED. Furthermore, GED was able to normalize the expression levels of E-cadherin and beta-catenin and upregulated GSK-3 beta, that are all known to be involved both in EMT and fibrosis. Conclusions The DSS-induced intestina

摘要： Nowadays the costs of specialized offshore crane vessels can roughly vary between 80,000 and 350,000 per day. The impact of those vessel day-rates on the costs of offshore operations is signifi- cant. In order to optimise this part of the costs, the deployment of offshore vessels has to be studied an mapped which is referred to as the workability of a vessel. Often workability studies are made for three different phases namely the early stage in an planning, days before the vessel sails towards the jobsite and hours or minutes before the execution of the operation. The latter is the point of no return for which the decision maker would like to have the most accurate information about the capability of the vessel to determine if the operation can be executed safely or not. In order to support the decision maker, so called Decision Support Tools are available. The Mocean Capability Tool is such a tool which moreover features an inertial measurement unit which continuously registers the motions of the vessel. Therefore the question arose whether it is possible to retrieve useful information from these measurements for making a more accurate prediction of the vessel response and decision making operation. There are numerous methods and techniques available that are able to predict a phenomenon based on the time signal of that phenomenon if it can be described by a stochastic harmonic process. This applies also to predominantly wave induced vessel responses. The capability of the vessel is determined by the significant response at a certain sea state. Thus in order to determine the significant response of the vessel from response measurements at least a measurement period of 20 min is required. The validity of the energy of measured vessel responses, regardless of the correction method, reaches to the duration for which the sea state is stationary Gaussian distributed and for systems without changing dynamics. Thus opportunities for making a more accurate prediction of t

关键词： 高等学校   高校治理   院校研究   决策体系   决策支   持系统  

摘要： 决策支持系统是决策体系的重要组成部分。高校自身的特点决定了其决策支持系统具有特殊的重要性。调查发现,我国高校没有决策支持系统,或决策支持系统不健全,是实现科学决策的一个突出问题。院校研究的核心职能是通过收集与分析数据,为决策过程提供支持。为此,应在高教研究机构和发展规划处的基础上建立院校研究机构,大力发展院校研究。教育部门应重视和支持院校研究,使之成为高校决策体系中的决策支持系统;要加速国家教育数据库建设,并向院校研究人员开放;要进行新的人事制度设计,改革相应的考核晋升机制,完善相关制度。

关键词： 协同商务,公共服务平台,新材料产业,系统设计  

摘要： 论文面向武进新材料产业基地,针对协同商务的特点,搭建一个面向基地内企业及时提供园区公共信息发布、科技咨询、产品研发与创新、产品检测、设备租赁、产学研对接、科技金融、知识产权转化、产业商务协同、第三方物流、人才培养与人才输送等公共服务平台。论文从平台的需求分析、功能模块设计、系统实现的关键技术等方面详细阐述了平台的设计与实现过程。

关键词： 信息治疗   信息处方   卫生保健   医患关系   决策支持  

摘要： 介绍信息治疗起源及定义,分析信息处方、用户、保健时机等信息治疗的研究对象,阐述信息治疗在关系建立、成本效应、患者教育、患者安全、健康实现等方面的功效及在卫生保健中的应用,指出信息治疗未来的发展方向。

关键词： 数据处理   排水防涝   数学模型   方案优化   决策支持   叠加分析  

摘要： 分析排水防涝规划需要解决的问题以及需要的数据处理与技术支持,从数据处理角度,将排水防涝规划中各个步骤的核心内容归纳为数据的获取、分析、加工、生产和增值5个阶段,并阐述其内涵及特点。论述了数据处理技术的应用为城市排水系统规划方法带来的多项革新,包括依靠数学模型拓展水力计算方法、应用多因子叠加法评估内涝风险、通过方案的比选和优化制定内涝治理方案、借鉴数据价值发掘的理念拓展规划成果的应用等。

关键词： 跨境电子商务   物流   产业链   协同发展  

摘要： 近年来,我国跨境电子商务的交易规模逐年攀升,它与物流业的深度融合和协同发展不可分割。通过分析产业链视角下跨境电子商务与物流业发展的现状,指出跨境电子商务与物流业协同发展的必要性以及二者协同发展的制约因素,提出促进二者协同发展的相关对策。

关键词： 医疗健康   决策支持   大数据   综述  

摘要： 基于近几年医疗与健康决策支持的相关研究观点,提出行为级、逻辑级和基于数据分析三个视角。从行为级的流程改善、人的可靠性、医疗风险三个角度归纳医疗管理的品质与效率;逻辑级从系统鲁棒性优化和鲁棒性推理角度,归纳医疗决策系统鲁棒性研究。基于异构实体数据融合、多模态数据管理、数据分治问题,对医疗大数据带来的精准医疗决策相关研究成果进行归纳。提出了数据驱动的医疗决策将成为提高医疗品质与效率的主要手段,特别是互联网环境下智能医疗,将对医疗与健康决策产生颠覆性的影响,成为重要研究方向。

关键词： Faecalibacterium prausnitzii   inflammation   colitis models   MAM (Microbial Anti-inflammatory Molecule)   Lactococcus lactis   NF-kappa B  

摘要： Faecalibacterium prausnitzii and its supernatant showed protective effects in different chemically-induced colitis models in mice. Recently, we described 7 peptides found in the F prausnitzii supernatant, all belonging to a protein called Microbial Anti-inflammatory Molecule (MAM). These peptides were able to inhibit NF-kappa B pathway in vitro and showed anti-inflammatory properties in vivo in a DiNitroBenzene Sulfate (DNBS)-induced colitis model. In this current proof we tested MAM effect on NF-kB pathway in vivo, using a transgenic model of mice producing luciferase under the control of NF-kappa B promoter. Moreover, we tested this protein on Dextran Sodium Sulfate (DSS)-induced colitis in mice. To study the effect of MAM we orally administered to the mice a Lactococcus lactis strain carrying a plasmid containing the cDNA of MAM under the control of a eukaryotic promoter. L. lactis delivered plasmids in epithelial cells of the intestinal membrane allowing thus the production of MAM directly by host. We showed that MAM administration inhibits NF-kappa B pathway in vivo. We confirmed the anti-inflammatory properties of MAM in DNBS-induced colitis but also in DSS model. In DSS model MAM was able to inhibit Thl and Th17 immune response while in DNBS model MAM reduced Th1, Th2, and Th17 immune response and increased TGF beta production.

关键词： 羽毛球   致胜   决策  

摘要： 羽毛球比赛获胜一方的因素多种多样,利用计算机技术,分析羽毛球比赛获胜的因素,同时考虑一个系统应该具备的功能特点,合理地构建出羽毛球比赛致胜因素分析及其决策支持系统的框架。