关键词： 会计工作   决策支持   财务管理   研究团队   智能化   财会人员   信息技术水平   核心竞争优势  

摘要： 随着“互联网＋”、大数据、云计算和物联网技术的发展与广泛应用，企业的会计信息化程度和深度日渐提高，“互联网＋会计”“互联网＋审计”、会计大数据、大数据审计成为当前前沿理论研究和实务应用的热点。未来，数字货币、电子发票和电子档案的应用，会使很多会计工作都可以依靠互联网、云会计和大数据技术方便、快捷地完成，这样，财会人员就从日常繁杂的会计核算中解放出来，更多地从事企业的财务管理和决策支持工作，也会对财会人员的信息技术水平提出更高的要求。基于财务数据和业务数据融合的电子数据采集、处理、分析和利用水平．将成为未来财会人员的核心竞争优势。

关键词： 高危妊娠   预警   决策支持  

摘要： 本文通过对高危妊娠的预防治疗及监测管理的现状分析,提出危重病信息化监测管理的需求,阐述通过对孕产妇诊疗信息的采集、处理、监测和分析,建立围产期高危妊娠管理流程及监测预警信息系统,进一步降低孕产妇死亡率和围产儿死亡率以期造福临床。

关键词： 电子商务   生态系统   协同创新  

摘要： 电子商务生态系统在整个电子商务行业发展过程中起到了积极推动作用。由于生态系统自身在发展过程中出现的种种协调问题,极大的影响了系统的有序良性发展,构建电子商务生态系统的协同创新模式对其本身也是有积极影响的。

摘要： Background:Inflammatory bowel disease (IBD) is a chronic inflammatory disease affecting the gastrointestinal tract, which consists of two major forms: Crohn's disease (CD) and Ulcerative Colitis (UC). The impact of cigarette smoking on IBD has been well established by a large number of epidemiological studies in which exposure to cigarette smoke was associated with a higher risk of developing CD and with an increased severity in CD patients. By contrast, cigarette smoking was shown to be protective against UC. The incidence of UC is 2.5 times less frequent in smokers, and, after disease onset, it has been reported that smoking improves the course of the disease, decreases the frequency of flare-up episodes, decreases the need for steroid administration, and decreases the colectomy rate. It has also been established that smoking cessation improves CD and worsens UC. While there are numerous descriptive and epidemiological publications about cigarette smoking and IBD, few mechanistic studies have explored the effect of cigarette smoke exposure on intestinal ***:This study evaluated the impact of mainstream cigarette smoke (CS) on the severity of dextran sulfate sodium (DSS)-induced UC in C57BL/6 female mice. UC-like symptoms were induced using DSS administered through drinking water at a concentration of 5.0%. Three groups of animals, low, medium, and high exposure groups, were exposed to CS to a target concentration of 750 μg/l total particulate matter for 1, 2, and 4 h per day, respectively. A 2-week CS pre-exposure period (including a 6-day concentration adaptation to the target CS concentration) was included to acclimatize the animals to the target CS concentration. This was followed by an 8-day CS treatment combined with DSS or control (drinking water only), after which the animals were evaluated for the progression and severity of UC ***:Using a comprehensive profiling approach (transcriptomics and proteomics) together with classica

关键词： 中医辨证施护   决策支持系统   中医护理   护理工作流程   中医临床护理   护理事业发展   在职培训   护理人员   设计框架   传统护理  

摘要： 辨证施护是指导中医临床护理的基本原则[1],《全国护理事业发展规划（2016-2020）》对＂辨证施护＂也提出明确指示[2]。但护理人员大多存在中医护理知识缺乏的问题,其中最欠缺的是＂辨证施护和传统护理技术相关知识＂[3]。对此,除加强在职培训外,护理信息化建设中临床决策支持系统（clinical decision support system,CDSS）的引入或成为一条新途径。本次研究结合护理工作流程,初步探讨基于护理程序的中医辨证施护CDSS的构建。

关键词： 财务共享   服务中心   财务运行   决策支持  

摘要： 2016年6月财政部颁布了《管理会计基本指引》,该指引强调管理会计创新工具要为企业决策提供支持。本文从BW公司财务共享服务中心的运行现状出发,对该公司财务共享服务中心的建设、目前面临的问题及改进对策进行了分析和探讨。BW公司财务共享中心运行在风险管控、决策支持等方面取得了显著效果,但也应该看到财务共享服务中心面临的挑战多种多样。希望通过本文的研究,对其它企业在实施和完善财务共享服务中心等管理会计创新工具方面具有启发及借鉴意义。

关键词： 流域   水资源   调度模型   监控平台   会商   决策支持  

摘要： 阐述海河流域水资源监控平台中水资源调度模型的建立意义、设计目标、工作方式。以引滦水资源调度模型为例,通过分析区域水量调度基本情况和特点,率定水资源调度模型中的输入和输出参数,分析资源调度模型设计,例举出在信息查询、方案管理、方案后评估方面的实际调度,监控中心和分中心会商,信息查询和管理、模拟仿真方面的决策支持等应用功能。针对模型现存问题,提出增强模型应用的贴合性、实时性和交互性等应用建议。水资源调配模型将为流域开展水资源计划、实时调度等提供决策支持,使流域水资源调度的运行管理更趋于科学合理。

关键词： wogonin   exacerbate   colitis   effector T cell   regulatory T cell  

摘要： Wogonin exerts anti-tumour activities via multiple mechanisms. We have identified that high-dose wogonin (50 or 100 mg/kg) could inhibit the growth of transplanted tumours by directly inducing tumour apoptosis and promoting DC, T and NK cell recruitment into tumour tissues to enhance immune surveillance. However, wogonin (20-50 M) ex vivo prevents inflammation by inhibiting NF-B and Erk signalling of macrophages and epithelial cells. It is elusive whether high-dose wogonin promotes or prevents inflammation. To investigate the effects of high-dose wogonin on murine colitis induced by dextran sodium sulphate (DSS), mice were co-treated with DSS and various doses of wogonin. Intraperitoneal administration of wogonin (100 mg/kg) exacerbated DSS-induced murine colitis. More CD4(+) CD44(+) and CD8(+) CD44(+) cells were located in the inflamed colons in the wogonin (100 mg/kg) treatment group than in the other groups. Frequencies of CD4(+) CD25(+) CD127(-) and CD4(+) CD25(+) Foxp3(+) cells in the colons and spleen respectively, were reduced by wogonin treatment. Ex vivo stimulations with high-dose wogonin (50-100 g/ml equivalent to 176-352 M) could synergize with IL-2 to promote the functions of CD4(+) and CD8(+) cells. However, regulatory T cell induction was inhibited. Wogonin stimulated the activation of NF-B and Erk but down-regulated STAT3 phosphorylation in the CD4(+) T cells. Wogonin down-regulated Erk and STAT3-Y705 phosphorylation in the regulatory T cells but promoted NF-B and STAT3-S727 activation. Our study demonstrated that high-dose wogonin treatments would enhance immune activity by stimulating the effector T cells and by down-regulating regulatory T cells.

关键词： MicroRNA-124   Nicotine   Ulcerative colitis   p-STAT3   Colon epithelial cell   Human T lymphocytes  

摘要： Although it is generally believed that nicotine accounts for the beneficial effect of smoking on ulcerative colitis, the underlying mechanisms remain not well understood. Our previous finding that nicotine inhibits inflammatory responses through inducing miR-124 prompted us to ask whether the miRNA is involved in the protective action of nicotine against UC. Our present study found that miR-124 expression is upregulated in colon tissues from UC patients and DSS colitis mice. Nicotine treatment further augmented miR-124 expression in lymphocytes isolated from human ulcerative colonic mucosa and ulcerative colon tissues from DSS mice, both in infiltrated lymphocytes and epithelial cells. Moreover, knockdown of miR-124 significantly diminished the beneficial effect of nicotine on murine colitis and IL-6-treated Caco-2 colon epithelial cells. Further analysis indicated that nicotine inhibited STAT3 activation in vivo and in IL-6 treated Caco-2 cells and Jurkat human T lymphocytes, in which miR-124 knockdown led to increased activation of STAT3. Blocking STAT3 activity alone is beneficial for DSS colitis and also abolished nicotine's protective effect in this model. These data indicate that nicotine exerts its protective action in UC through inducing miR-124 and inhibiting STAT3, and suggest that the miR-124/STAT3 system is a potential target for the therapeutic intervention of UC. Nicotine upregulates miR-124 expression in ulcerative colon tissues and cells. MiR-124 is required for the protective role of nicotine in DSS colitis mice and epithelial cells. The protective effect of nicotine in murine DSS colitis depends on blocking STAT3 activation. MiR-124 mediates the inhibitory role of nicotine on STAT3/p-STAT3. Targeting miR-124 and STAT3 represents a novel approach for treating ulcerative colitis.

关键词： Inflammatory bowel disease   DSS   Colitis   High fiber diet  

摘要： Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders with important impact on global health. Prebiotic and probiotic strategies are thought to be useful in the context of experimental IBD. Here, we compared the effects of preventive versus therapeutic treatment with a high fiber diet (prebiotic) in combination or not with Bifidobacterium longum (probiotic) in a murine model of chronic colitis. Colitis was induced by adding dextran sulfate sodium (DSS) to drinking water for 6 days (acute colitis) or for 5 cycles of DSS (chronic colitis). Administration of the high fiber diet protected from acute colitis. Protection was optimal when diet was started 20 days prior to DSS. A 5-day pretreatment with acetate, a short-chain fatty acid, provided partial protection against acute colitis. In chronic colitis, pretreatment with the high fiber diet attenuated clinical and inflammatory parameters of disease. However, when the treatment with the high fiber diet started after disease had been established, overall protection was minimal. Similarly, delayed treatment with acetate or B. longum did not provide any protection even when the probiotic was associated with the high fiber diet. Preventive use of a high fiber diet or acetate clearly protects mice against acute and chronic damage induced by DSS in mice. However, protection is lost when therapies are initiated after disease has been established. These results suggest that any therapy aimed at modifying the gut environment (e.g., prebiotic or probiotic strategies) should be given early in the course of disease.