关键词： Colitis   Inflammatory bowel disease   Dextran sulphate sodium   Imidazoline receptor  

摘要： Imidazoline receptors (IRs) have been recognized as promising targets in the treatment of numerous diseases;and moxonidine and rilmenidine, agonists of I-1-IRs, are widely used as antihypertensive agents. Some evidence suggests that IR ligands may induce anti-inflammatory effects acting on I-1-IRs or other molecular targets, which could be beneficial in patients with inflammatory bowel disease (IBD). On the other hand, several IR ligands may stimulate also alpha(2)-adrenoceptors, which were earlier shown to inhibit, but in more recent studies to rather aggravate colitis. Hence, this study aimed to analyse for the first time the effect of various I-1-IR ligands on intestinal inflammation. Colitis was induced in C57BL/6 mice by adding dextran sulphate sodium (DSS) to the drinking water for 7 days. Mice were treated daily with different IR ligands: moxonidine and rilmenidine (I-1-IR agonists), AGN 192403 (highly selective I-1-IR ligand, putative antagonist), efaroxan (I-1-IR antagonist), as well as with the endogenous IR agonists agmatine and harmane. It was found that moxonidine and rilmenidine at clinically relevant doses, similarly to the other IR ligands, do not have a significant impact on the macroscopic and histological signs of DSS-evoked inflammation. Likewise, colonic myeloperoxidase and serum interleukin-6 levels remained unchanged in response to these agents. Thus, our study demonstrates that imidazoline ligands do not influence significantly the severity of DSS-colitis in mice and suggest that they probably neither affect the course of IBD in humans. However, the translational value of these findings needs to be verified with other experimental colitis models and human studies.

关键词： Apoptosis   AMPK alpha   Bcl2   Colitis   Dietary supplement   IL-1 beta   Le Carbone   TNF alpha  

摘要： Le Carbone (LC) is a charcoal supplement, which contains a large amount of dietary fibers. Several studies suggested that charcoal supplement may be beneficial for stomach disorders, diarrhea, gas and indigestion. But no studies address whether LC intake would suppress inflammation, cell proliferation or disease progression in colitis. In the present study, the effect of LC on experimental colitis induced by dextran sulfate sodium (DSS) in mice and its possible mechanism of action were examined. A study was designed for 8 days, using C57BL/6 female mice that were administered with 3% DSS in drinking water for 7 days followed by another 1 day consumption of normal water with or without treatment. LC suspension was administered daily for 7 days via oral gavage using 5 mg/mouse in treatment group and normal group was supplied with drinking water. LC suspension significantly attenuated the loss of body weight and shortening of colon length induced by DSS. The disease activity index, histopathologic changes were significantly reduced by LC treatment. The inflammatory mediators TNF alpha, IL-1 beta, p-STAT3 and p-NF-kappa B induced in the colon by DSS were markedly suppressed by LC The increased activation of AMPK alpha in the colon was also detected in LC group. Furthermore, the apoptotic marker protein cleaved caspase 3 was down-regulated and anti-apoptotic proteins Bcl2 and Bcl-xL were significantly up-regulated by LC treatment. Taken together, our results demonstrate the ability of LC to inhibit inflammation, apoptosis and give some evidence for its potential use as adjuvant treatment of inflammatory bowel disease. (C) 2016 Elsevier B.V. All rights reserved.

标准号: CFR 23-635.506-2017

关键词： 物流   电子商务   社会协同化  

摘要： 自20世纪90年代电子商务从国外引入以来,就因其方便快捷和能带来巨大的经济利益而得到了迅速的发展。电子商务这种不同于传统商业的模式因其省时省力等特点迅速在在我国流行起来。网购更多的是单个消费者购买单个商品,而且每个消费者需要运送的地址往往也是不一样的,这就造成了物流运输的量需要达到一定的程度才能有效的减少运输成本。但是单个的中小电子商务企业往往很难做到在消费者购买少量产品时还能做到减少运输成本的要求。所以这就需要第三方物流的协同运输,而协同运输的话,各个电商企业和各个物流行业的信息需要进行充分的交流,现如今是大数据时代,能够很好的完成这一工作。为了充分说明大数据和社会协同化对现代物流的重要影响,本文通过分析我国从2009年起的"双十一"购物狂欢节中产生种种相关数据,分析物流发展现状并大胆预测电子商务物流的发展趋势及其前景,为相关领域研究提供借鉴。

关键词： 医院人力资源管理   决策支持系统   应用  

摘要： 本文结合决策支持系统理念,浅析该理念在医院人力资源管理中的应用及优势,包括对医院人力资源管理信息的分析、处理、展示及信息质量优化,进而推进医院人力资源的精细化管理,更充分地发挥人力资源管理部门的重要职能。

关键词： 数据分析   决策支持   企业生产经营   能力   培养   建筑施工企业   企业管理   工程进度  

摘要： 在建筑施工企业,企业生产经营数据分析,对于项目管控和企业管理至关重要。如果生产经营数据能够及时、准确地反馈,管理者通过对各类数据进行综合分析,就可以准确掌握公司各项目的工程进度,财务成本,营业收入等情况。信息化很重要的目的之一,就是对各类业务数据进行综合分析,提供决策支持。

关键词： 电子商务   现代物流   协同发展  

摘要： 近年来,传统企业营销电子商务化的趋势日趋明显,触网成为传统企业面对经济新常态的战略选择。同时,电子商务从城镇向农村市场的延伸,农村电商的蓝海市场机遇成为各方共识。但是,电子商务的纵深发展却受制于现代物流体系难以实现预期的快速增长,现代物流如何更好的支撑电子商务的纵深发展,电子商务又如何促进现代物流体系的成熟发展,为此电商与物流的协同发展成为急需解决的现实问题。

关键词： 水环境   决策支持系统   污染物溯源   分析功能   设计  

摘要： 参考当前污染物溯源分析研究进展,结合牡丹江污染物排放特征,设计水环境管理决策支持系统中的污染物溯源分析功能,以期提高牡丹江流域的水环境监管能力。

关键词： 城市交通管理   智能化   决策支持系统   开发应用  

摘要： 信息技术的发展带动了社会的进步,而在城市交通管理中信息技术也为交通管理带来了许多便利。本文,笔者将根据当前城市的交通管理决策现状,分析交通管理智能化决策支持系统的开发与应用,以求城市交通管理朝着更好的方向发展。

关键词： 决策支持与商务智能   上机考试   更新教学内容  

摘要： 为了改革课堂教学,提高教学效果,尝试在《决策支持与商务智能》课程中实施翻转课堂教学模式,变传统的试卷模式为上机操作考试,并对教学内容进行更新和完善,取得了较好的效果。