关键词： Hybrid teaching   hybrid learning   hyflex   dual-delivery teaching   synchronous teaching   multi-modal teaching   Adult Education and Lifelong Learning   Classroom Practice   Higher Education   Post-Compulsory Education   Research Methods in Education  

摘要： This paper evaluates the hybrid teaching practices at City St. George's, University of London through a unique study of the experiences of staff and students in using these spaces for learning. The university was an early adopter of hybrid teaching in UK higher education and implemented it at scale and continues to use and develop this practice. Our evaluation focuses on practical insights gathered from two mixed-methods surveys, which included both qualitative and quantitative questions, conducted over the academic year 2021-2022. Additionally, staff focus groups were held to further explore survey findings. Responses highlighted the benefits of inclusivity in the hybrid teaching approach, though it also revealed mixed engagement levels among online students. The study also uncovered various challenges and technical issues faced by staff and students, providing valuable insights for improving future hybrid teaching practices. As this was an early implementation of this practice in a planned way, this snapshot analysis provides a useful baseline for understanding how hybrid teaching and experience will continue to develop. These findings will inform strategic decisions related to engagement, pedagogy, technology, space design, and staff development, as well as support a community of practice with other educational institutions.

关键词： Antipsychotic   off-label use   metabolic   marketing  

摘要： Soon after the introduction of second-generation antipsychotics, antipsychotic off-label use (OLU) progressively became a common prescribing practice. This evolving practice should be regularly monitored considering the growing number of persons exposed to the adverse effects of antipsychotics. The aim of the present review was to synthesise the literature published over the last 15 years on antipsychotic OLU for mental health symptoms. Observational studies confirm the persisting high rate of antipsychotic OLU prescription in two out of three youths and 30-60% of adults using antipsychotics. Increasing rates of low-dose quetiapine prescriptions for anxiety or sleep symptoms are paradigmatic of the current public health concern regarding antipsychotic OLU. Such prescriptions receive impetus from industry-funded marketing strategies and prescribers' feeling of innocuousness, with a resulting underestimation of the risk of adverse drug reactions (ADR). However, antipsychotic OLU should be neither trivialised nor demonised since it may be the only therapeutic option in persons with resistant psychiatric disorders or serious ADR with labelled drugs. To reduce the populational impact of antipsychotic OLU, it is necessary to better control the influence of the pharmaceutical industry regarding newly marketed drugs and to better inform prescribers and users about the risks associated with OLU prescribing.

关键词： Digital wellbeing   virtual education   e-learning   distance learning   digital literacy   digitalisation   Higher Education   Open & Distance Education and eLearning   Information Technology  

摘要： This study examined digital literacy gaps impacting the promotion of the 21st century skills among students in higher education institutions in sub-Saharan Africa. As many institutions undergo technological transformations, understanding these gaps is crucial for equipping graduates with the required digital workforce skills. The review synthesized findings from 14 empirical studies published between 2016 and 2023 using content analysis through *** software to identify patterns. Key findings revealed that 21st century skills are insufficiently developed due to inadequate digital infrastructure and unprepared lecturers. Additionally, outdated or nonexistent ICT policies hinder the effective adoption of technology in teaching. The study calls for reforms in curricula to prioritize digital solutions and enhance professional development for educators. Improved digital literacy is vital for preparing students for the job market and fostering broader socio-economic development in sub-Saharan Africa. Future research should investigate long-term trends and evaluate the effectiveness of digital literacy initiatives across varied educational contexts.

关键词： Sialyltransferase   ST8Sia1   rectal adenocarcinoma   CD8+T-cell   immune microenvironment  

摘要： BackgroundRectal adenocarcinoma (READ) involves the dysregulated expression of alpha 2,8-Sialyltransferase1 (ST8Sia1) although its role during READ's progression is *** mRNA level of ST8Sia1 was analyzed based on The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Tumor Immune Estimation Resource (TIMER) 2.0. Furthermore, the prognostic and significance of ST8Sia1 in READ was assessed through Kaplan-Meier curve, univariate, multivariate Cox regression, and receiver operating characteristic (ROC) methods. The role of ST8Sia1 in the READ immune microenvironment was explored using ESTIMATE analysis and TIMER databases. Furthermore, the expression of ST8Sia1 in tissues was analyzed using real-time quantitative polymerase chain reaction (RT-qPCR), western blotting (WB), and immunohistochemistry (IHC). Perforin and Granzyme B secretion by CD8+ T cells, as well as tumor cell apoptosis, were detected after co-culturing CD8+ T cells with READ tumor cells and ST8Sia1-overexpression (ST8Sia1-OE) tumor cells. Furthermore, we examined the interaction between ST8Sia1 and TGF-beta 1 in READ ***8Sia1 exhibited excellent diagnostic capability for READ, with positive correlations to immune response and negative correlations to tumor purity. Increased levels of perforin and Granzyme B from CD8+ T cells were observed in vitro, enhancing tumor cell apoptosis. ST8Sia1 interacts with TGF-beta 1, mediating its inhibitory effects on READ ***8Sia1 is a potential diagnostic biomarker and therapeutic target for READ, enhancing CD8+ T cell function and possibly improving patient outcomes through cellular immunotherapy.

关键词： comparative historiography   critical criminology   European Union   history of financial crime   Jordan  

摘要： This article describes the dialectical development of financial crimes in the European Union and Jordan during the 21st century from the perspective of critical criminology. The methodology combines a comparative documentary analysis of legislation, institutional frameworks, and jurisprudence, with a qualitative approach based on legal hermeneutics. Critical criminology questions the social construction of financial crime and explores how structural inequalities and the interests of economic elites have shaped institutional responses. It argues that, despite cultural and legal differences, both the EU and Jordan have experienced selective criminalization that tends to protect the most powerful actors in the financial system. By way of contribution, this study contributes to a critical understanding of how power and inequality influence the conceptualization and social control of economic criminality at the transnational level. In conclusion, if diverse methodologies and theoretical approaches are harmoniously articulated, a more complete vision can be obtained, one that not only identifies the specific characteristics of the phenomenon in each region, but also recognizes the global interconnections that underlie the commission of economic crime as a transnational phenomenon. © 2025, Ediciones Clio. All rights reserved.

关键词： Longitudinal strain   Myocardial infarction   Quantitative microvascular perfusion  

摘要： Objective: This study aims to investigate the relationship between segmental longitudinal strain (LS) and quantitative microvascular perfusion (qMVP) in patients with ST-segment elevation myocardial infarction (STEMI), and to explore the prognostic value of the two indicators after STEMI. Methods: The retrospective study enrolled 61 patients who underwent primary percutaneous coronary intervention (pPCI) for first STEMI. Microvascular perfusion (MVP) and qMVP were analyzed by myocardial contrast echocardiography (MCE), and segmental LS was analyzed by two-dimensional speckle tracking echocardiography (2D-STE). Myocardial wall perfusion was qualitatively assessed visually. Quantitative myocardial perfusion parameters were analyzed using an 18-segment model. The correlation between segmental LS and qMVP was assessed. The prognostic value of segmental LS and qMVP for major cardiac adverse events were evaluated. Results: Among the 314 segments with abnormal wall motion, 44 showed normal microvascular perfusion (nMVP), 87 showed delayed microvascular perfusion (dMVP), and 183 exhibited microvascular obstruction (MVO). Segmental LS was correlated with segmental wall motion (WM) and qMVP. At 12-month follow-up, 19 patients experienced cardiac events. NT-proBNP, regional LS (rLS), and regional qMVP (r-qMVP) were associated with cardiac events. The area under curve (AUC) of combination of rLS and r-qMVP was bigger than single indicator for identifying prognostic value (P < 0.001). Conclusion: Segmental LS indices are correlated with qMVP within the infarct zone following reperfused STEMI. Both rLS and r-qMVP are sensitive to myocardial damage and provide prognostic value for clinical events after STEMI. And the combination of rLS and r-qMVP shows improved predictive ability compared to a single indicator. © The Author(s) 2025.

摘要： The Editor-in-Chief has retracted this article. After publication, concerns were raised regarding highly similar images in the figures, specifically: Fig. 4g SMMC7721 pre-NC image appears to overlap with Fig. 6d SMMC7721 sh-MIR31HG+anti-miR-575;Fig. 4h SMMC7721 pre-NC image appears to overlap with Fig. 6e SMMC7721 pcDNA3.1-MIR31HG+pre-miR-575. Fig. 4g SMMC7721 pre-NC image appears to overlap with Fig. 6d SMMC7721 sh-MIR31HG+anti-miR-575;Fig. 4h SMMC7721 pre-NC image appears to overlap with Fig. 6e SMMC7721 pcDNA3.1-MIR31HG+pre-miR-575. The authors checked their data and found that in Fig. 2c, SMMC7721 pcDNA3.1-MIR31HG and sh-MIR31HG 0h images were the same, and Fig. 2c HepG2 pcDNA3.1-MIR31HG 36h and Fig. 4f HepG2 anti-NC 0h images originated from the same sample. Further checks by the Publisher have also identified a potential error in Fig. 6e, where HepG2 sh-MIR31HG+anti-miR-575 and pcDNA3.1+pre-NC images appear to originate from the same sample. The authors requested a Correction and provided the original image files and cell line authentication documents. However, the STR profiling results of the cell lines used in the in vitro and in vivo experiments this study revealed that the SMMC7721 and L-02 cell lines were contaminated with HeLa cervical cancer cells, making them an unsuitable model for liver cancer. This partially undermines the main conclusions of the article, which are specific to hepatocellular carcinoma. The Editor-in-Chief therefore no longer has confidence in the presented data and conclusions of this artilcle. Shaoying Yan and Hua Tang disagree with this retraction. None of the other authors have responded to any correspondence from the Publisher about this retraction. © The Author(s) 2025.

关键词： MSC-EVs   Scars   ST   UCB-EVs   Wounds  

摘要： Extracellular vesicles (EVs) are important paracrine mediators derived from various cells and biological fluids, including plasma, that are capable of inducing regenerative effects by transferring bioactive molecules such as microRNAs (miRNAs). This study investigated the effect of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) isolated from umbilical cord blood and human umbilical cord plasma-derived extracellular vesicles (UCB-EVs) on wound healing and scar formation reduction. Spatial transcriptomics (ST) was used to study the effects of MSC-EVs and UCB-EVs on the heterogeneity of major cell types and wound healing pathways in mouse skin tissue. MSC-EVs and UCB-EVs were isolated using ultracentrifugation and identified using transmission electron microscopy, nanoparticle tracking analysis, and western blot. The effects of MSC-EVs and UCB-EVs on human dermal fibroblast-adult cell (HDF-a) migration and proliferation were evaluated using cell scratch assays, cell migration assays, and cell proliferation assays. In vivo, MSC-EVs and UCB-EVs were injected around full-cut wounds to evaluate their efficacy of wound healing by measuring wound closure rates and scar width and performing histological analysis. ST was performed on skin tissue samples from mice in each group after wound healing to analyze the heterogeneity of major cell types compared with the control group and investigate potential mechanisms affecting wound healing and scar formation. In vitro experiments demonstrated that MSC-EVs and UCB-EVs promoted the proliferation and migration of HDF-a cells. Local injection of MSC-EVs and UCB-EVs into the periphery of a mouse skin wound accelerated re-epithelialization, promoted wound healing, and reduced scar width. ST analysis of skin tissue from each group after wound healing revealed that MSC-EVs and UCB-EVs reduced the relative expression of marker genes in myofibroblasts, regulated wound healing, and decreased scar formation by reducing the exp