关键词： Digital wellbeing   virtual education   e-learning   distance learning   digital literacy   digitalisation   Higher Education   Open & Distance Education and eLearning   Information Technology  

摘要： This study examined digital literacy gaps impacting the promotion of the 21st century skills among students in higher education institutions in sub-Saharan Africa. As many institutions undergo technological transformations, understanding these gaps is crucial for equipping graduates with the required digital workforce skills. The review synthesized findings from 14 empirical studies published between 2016 and 2023 using content analysis through *** software to identify patterns. Key findings revealed that 21st century skills are insufficiently developed due to inadequate digital infrastructure and unprepared lecturers. Additionally, outdated or nonexistent ICT policies hinder the effective adoption of technology in teaching. The study calls for reforms in curricula to prioritize digital solutions and enhance professional development for educators. Improved digital literacy is vital for preparing students for the job market and fostering broader socio-economic development in sub-Saharan Africa. Future research should investigate long-term trends and evaluate the effectiveness of digital literacy initiatives across varied educational contexts.

关键词： Multidrug resistance   restrospective study   E.coli high risk clones   whole-genome sequencing   ST405  

摘要： The emergence of carbapenem-resistant Escherichia coli (CREC) poses crucial challenges in clinical management, requiring continuous monitoring to inform control and treatment strategies. This study aimed to investigate the genomic and epidemiological characteristics of CREC isolates obtained from a tertiary hospital in China between 2015 and 2022. Next-generation sequencing was used for genomic profiling, and clinical data from patients were integrated into the analysis. ST405 (21.2%), ST167 (20.3%) and ST410 (15.9%) were the most prevalent of the 30 distinct sequence types (STs) identified among the 113 unique CREC isolates. Infections caused by the ST405 CREC clone and severe underlying diseases were associated with higher in-hospital mortality rates, particularly in patients aged >= 65 years. Furthermore, the ST405 clone exhibited a greater number of virulence and resistance genes than non-ST405 CREC clones. The virulence gene eaeX and resistance genes mph(E) and msr(E) were exclusively found in ST405 clones, while other virulence genes (agn43, ipad and malX) and resistance genes (armA, catB3 and arr-3) were more prevalent in this clones. Additionally, ST405 showed higher minimum inhibitory concentrations for both meropenem and imipenem and showed superior growth under the meropenem challenge. Galleria mellonella virulence assays revealed that the ST405 CREC clone was more virulent than other predominant CREC STs. Our findings underscore the clinical threat posed by the ST405 CREC clone, which exhibits both enhanced virulence and extensive drug resistance. These results highlight the urgent need for stringent surveillance and targeted interventions to curb its further dissemination and prevent potential outbreaks.

关键词： Antipsychotic   off-label use   metabolic   marketing  

摘要： Soon after the introduction of second-generation antipsychotics, antipsychotic off-label use (OLU) progressively became a common prescribing practice. This evolving practice should be regularly monitored considering the growing number of persons exposed to the adverse effects of antipsychotics. The aim of the present review was to synthesise the literature published over the last 15 years on antipsychotic OLU for mental health symptoms. Observational studies confirm the persisting high rate of antipsychotic OLU prescription in two out of three youths and 30-60% of adults using antipsychotics. Increasing rates of low-dose quetiapine prescriptions for anxiety or sleep symptoms are paradigmatic of the current public health concern regarding antipsychotic OLU. Such prescriptions receive impetus from industry-funded marketing strategies and prescribers' feeling of innocuousness, with a resulting underestimation of the risk of adverse drug reactions (ADR). However, antipsychotic OLU should be neither trivialised nor demonised since it may be the only therapeutic option in persons with resistant psychiatric disorders or serious ADR with labelled drugs. To reduce the populational impact of antipsychotic OLU, it is necessary to better control the influence of the pharmaceutical industry regarding newly marketed drugs and to better inform prescribers and users about the risks associated with OLU prescribing.

关键词： Climate change   health adaptation strategies   sustainable health systems   global health equity   environmental sustainability  

摘要： Global health is at a critical juncture, with significant achievements in reducing deaths from HIV and under-five mortality since 2000. However, progress in other areas, such as maternal mortality and tuberculosis, remains uneven, and cardiovascular diseases continue to rise. Compounding these challenges is the emerging threat of climate change, which is predicted to cause millions of health-related deaths by the end of the century. This commentary proposes a new global health model inspired by Kate Raworth's 'doughnut' framework, which emphasizes maintaining ecological and social boundaries to foster sustainable health. The inner boundary focuses on ensuring equitable access to essential health services, particularly for underserved populations. The outer boundary addresses the health impacts of environmental degradation and climate change, advocating for adaptive and resilient health systems. This model calls for a reorientation of global health priorities to balance human well-being with environmental sustainability, urging international collective action at platforms like COP29. By addressing both health equity and ecological stability, this framework aims to guide the global health community towards a more equitable and sustainable future.

关键词： Internship experiences   employability   vocational schools   21st-century competencies   psychological capital   Educational Psychology   Business, Management and Accounting   Study Skills   Adult Education and Lifelong Learning   Secondary Education   Information Technology  

摘要： Using the social cognitive theory, this study examines the mediation role of 21st-century competencies in the relationship between student internship sxperience and employability of vocational students and the role of moderation of psychological capital on the relationship between SIE and 21stCE. This study aims to analyse the employability of vocational students through internship experience and 21st century competencies through a moderated mediation model. This study collected data through a direct survey of 266 vocational students in Aceh Province. SPSS V.25 and SmartPLS 4.***.0.3 are used to test the proposed hypothesis. The findings revealed that SIE positively increased EVS through the 21stCE. Further research shows that the effect of SIE on 21stCE is more significant for students with high PsyCap than for low PsyCap. This study expands the existing literature on the relationship between SIE and EVS by integrating SCT from the perspective of vocational education. These findings offer valuable insights and guidance for policymakers for education management regarding how and when SIE leads to better EVS among vocational students. This is one of the pioneering empirical studies highlighting SIE's importance to EVS among vocational students in the developing Aceh Province in Southeast Asia. In addition, the study confirms that 21st-century competencies play an essential role in explaining how SIE drives EVS.

关键词： Hybrid teaching   hybrid learning   hyflex   dual-delivery teaching   synchronous teaching   multi-modal teaching   Adult Education and Lifelong Learning   Classroom Practice   Higher Education   Post-Compulsory Education   Research Methods in Education  

摘要： This paper evaluates the hybrid teaching practices at City St. George's, University of London through a unique study of the experiences of staff and students in using these spaces for learning. The university was an early adopter of hybrid teaching in UK higher education and implemented it at scale and continues to use and develop this practice. Our evaluation focuses on practical insights gathered from two mixed-methods surveys, which included both qualitative and quantitative questions, conducted over the academic year 2021-2022. Additionally, staff focus groups were held to further explore survey findings. Responses highlighted the benefits of inclusivity in the hybrid teaching approach, though it also revealed mixed engagement levels among online students. The study also uncovered various challenges and technical issues faced by staff and students, providing valuable insights for improving future hybrid teaching practices. As this was an early implementation of this practice in a planned way, this snapshot analysis provides a useful baseline for understanding how hybrid teaching and experience will continue to develop. These findings will inform strategic decisions related to engagement, pedagogy, technology, space design, and staff development, as well as support a community of practice with other educational institutions.

关键词： Sialyltransferase   ST8Sia1   rectal adenocarcinoma   CD8+T-cell   immune microenvironment  

摘要： BackgroundRectal adenocarcinoma (READ) involves the dysregulated expression of alpha 2,8-Sialyltransferase1 (ST8Sia1) although its role during READ's progression is *** mRNA level of ST8Sia1 was analyzed based on The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Tumor Immune Estimation Resource (TIMER) 2.0. Furthermore, the prognostic and significance of ST8Sia1 in READ was assessed through Kaplan-Meier curve, univariate, multivariate Cox regression, and receiver operating characteristic (ROC) methods. The role of ST8Sia1 in the READ immune microenvironment was explored using ESTIMATE analysis and TIMER databases. Furthermore, the expression of ST8Sia1 in tissues was analyzed using real-time quantitative polymerase chain reaction (RT-qPCR), western blotting (WB), and immunohistochemistry (IHC). Perforin and Granzyme B secretion by CD8+ T cells, as well as tumor cell apoptosis, were detected after co-culturing CD8+ T cells with READ tumor cells and ST8Sia1-overexpression (ST8Sia1-OE) tumor cells. Furthermore, we examined the interaction between ST8Sia1 and TGF-beta 1 in READ ***8Sia1 exhibited excellent diagnostic capability for READ, with positive correlations to immune response and negative correlations to tumor purity. Increased levels of perforin and Granzyme B from CD8+ T cells were observed in vitro, enhancing tumor cell apoptosis. ST8Sia1 interacts with TGF-beta 1, mediating its inhibitory effects on READ ***8Sia1 is a potential diagnostic biomarker and therapeutic target for READ, enhancing CD8+ T cell function and possibly improving patient outcomes through cellular immunotherapy.

关键词： comparative historiography   critical criminology   European Union   history of financial crime   Jordan  

摘要： This article describes the dialectical development of financial crimes in the European Union and Jordan during the 21st century from the perspective of critical criminology. The methodology combines a comparative documentary analysis of legislation, institutional frameworks, and jurisprudence, with a qualitative approach based on legal hermeneutics. Critical criminology questions the social construction of financial crime and explores how structural inequalities and the interests of economic elites have shaped institutional responses. It argues that, despite cultural and legal differences, both the EU and Jordan have experienced selective criminalization that tends to protect the most powerful actors in the financial system. By way of contribution, this study contributes to a critical understanding of how power and inequality influence the conceptualization and social control of economic criminality at the transnational level. In conclusion, if diverse methodologies and theoretical approaches are harmoniously articulated, a more complete vision can be obtained, one that not only identifies the specific characteristics of the phenomenon in each region, but also recognizes the global interconnections that underlie the commission of economic crime as a transnational phenomenon. © 2025, Ediciones Clio. All rights reserved.