摘要： 针对课后托管课堂的独特性、丰富性和综合需求,教师应当坚持"共性成长与个性发展"这一整体目标,采用"看护辅导与特色活动"相结合的双重模式.具体来说,教师可以推行"一看、二辅、三提升"模式,同时构建"多元化课程、多样化途径、多样化活动与多维度评价"的"四多"体系,以此提升小学语文课后服务的质量和成效.

关键词： hydroponics   3D printing   21st century skills   elementary students  

摘要： This article reports on a mixed-methods evaluation of a hydroponics-based learning curriculum for fourth and fifth grade students that incorporated 3D design and 3D printing technologies. This study provides a better understanding of the extent to which experiential indoor gardening applications can be used in the formal curriculum as an effective teaching tool to sensitize participants to the prudent use of water, avoiding its wastage. The primary objective was to introduce students to the processes of 3D printing and hydroponics, while also assessing the enhancement of their 21st century skills. The participating students presented significant improvement in environmental knowledge scores about hydroponics, as well as high overall scores on collaboration, creativity, communication, and critical thinking (the 4Cs). The teachers noted the modern, innovative character of the program, as well as the ease of use of the included, offered, educational material.

关键词： 数字化转型   比较研究   流程优化  

摘要： 对比分析了国内外邮政企业在数字化转型中的发展阶段、背景、策略以及成效,通过深入研究德国、新西兰和美国等国外邮政企业的数字化进程,总结了其在技术应用、运营模式等方面的成功经验.同时,对比国内邮政企业的发展现状,探讨了两者之间的异同.基于此,提出针对中国邮政在领导力、资源配置、流程优化等方面的改进建议,以期为国内邮政企业提供更具前瞻性和创新性的数字化改造路径.

关键词： Portuguese St. James Way   Pilgrims' profile and motivations   Landscape   Well-being  

摘要： There are many studies on the St. James Way, also known as the Camino de Santiago, but not enough attention has been paid to the pilgrims' perceptions and motivations, particularly those who choose to do the Portuguese Way. Their motivations may be related to the landscape, the spiritual dimension, the search for well-being and self-therapy, or the need to cope with life's challenges. This study aimed to identify the motivations, profile, and satisfaction of pilgrims on the Portuguese St. James Way. Regarding satisfaction, we also looked at the lack of services or goods provided along the Way. A total of 351 pilgrims responded to a questionnaire, which was complemented by participant observation to obtain some data. The results show that pilgrims' motivations were mainly spiritual and cultural. Regarding the pilgrims' profile, we concluded that most were between 25 and 64 years old, had a high level of education and a formal job, and were doing the Way on foot. Apart from nationality, duration of the walk, and who organized the trip, there were few differences between the pilgrims. Out of the total, 57.3% expressed great satisfaction with the Portuguese St. James Way (the Central Route), which corresponded to their initial expectations. Based on pilgrims' and researchers' assessments, we offer policy recommendations to the local authorities aimed at maximizing pilgrims' well-being.

关键词： Aedes aegypti   bioinsecticide   Cerrado   Magonia pubescens   UHPLC-MS/MS  

摘要： Plant-derived compound emerges as alternatives to integrated control of Aedes aegypti, the main transmitter of Chikungunya, Dengue, Zika virus. The effects of Magonia pubescens A. St.-Hill extracts on Ae. aegypti larval development were assessed. Four in vitro assays analysed the insecticidal potential (% larval mortality) of aqueous and ethanolic (EE) extracts of leaves and seeds. The extracts were analysed using UHPLC-MS/MS. By comparing to data from three databases, 12 compounds from different classes were identified in the EE, including coumarins, phenolic acids, polyphenols, and flavonoids. The EE from the leaves was the most effective, with an LC90 of 0.262 mg/mL. Morphological alterations were observed in larvae exposed to the extracts, showing epithelial walls with extravasation of intestinal contents. These findings highlight the effectiveness of M. pubescens extract as a bioinsecticidal agent against Ae. aegypti larvae.

关键词： Klebsiella pneumoniae ST15   NDM-1   VIM-1   carbapenem resistance   metallo-beta-lactamase   antimicrobial resistance   ICU infections  

摘要： The emergence of carbapenemase-producing Klebsiella pneumoniae poses a significant global health threat, particularly in hospital settings. This study reports on the first detection of a pandrug-resistant (PDR) high-risk ST15 K. pneumoniae strain co-producing NDM-1 and VIM-1 in Greece. The isolate was recovered from a blood culture of a male patient admitted to the Intensive Care Unit (ICU) of Volos Hospital in July 2024. Next generation Sequencing (NGS) confirmed the presence of blaNDM-1 and blaVIM-1 genes. Other beta-lactamase type (CTX-M-15) was detected in association with NDM and VIM enzymes. Furthermore, this isolate was resistant to other antimicrobial agents, including aminoglycosides [aac(3)-II, aac(3)-IIe, aac(6 ')-Ib, aadA1, aph(3 '')-Ib, aph(6)-Id, aph(3 ')-Ia), chloramphenicol (catB3), fluoroquinolones (qnrS1) and sulfonamides (sul1 and sul2). The Multilocus Sequence Typing revealed that the strain belonged to ST15. According to Kaptive the strain belonged to KL48. Our study provides new data about MBL producing K. pneumoniae in Greece. Thus, we report for the first time the co-expression of blaNDM-1 and blaVIM-1 in our country in ST15 K. pneumoniae. This study provides crucial epidemiological data on MBL-producing K. pneumoniae in Greece and highlights the urgent need for enhanced surveillance, infection control strategies, and access to last-resort antibiotics such as aztreonam-avibactam.

关键词： Historical earthquakes   Greece   20th Century   Isoseismal maps  

摘要： Two earthquakes from the first half of the twentieth century in the Peloponnese region (southern Greece) are analyzed here. These earthquakes occurred 1 year apart in the summers of 1926 and 1927;epicentral locations in the literature show them close to each other (similar to 50 km apart). The earthquakes are of particular importance for at least two reasons: they appear to be of intermediate depth and macroseismic data associated with them has been available until now in paper format. Intermediate depth earthquakes are associated with the subduction zone along the Hellenic arc and do not occur as frequently as crustal earthquakes, therefore making the revisiting of such events even more important. Historical European databases which hold macroseismic data, such as AHEAD ((Albini et al. Istituto Nazionale Di Geofisica e Vulcanologia (INGV), 2013), are essential for disseminating this data type and making the different studies for each seismic event in the catalogue available. However, AHEAD includes earthquakes that occurred prior to 1900. Paradoxically, it is easier to find the macroseismic field of an earthquake from the 1500s than one from the early twentieth century. Therefore, disseminating and analyzing the macroseismic data of the two Peloponnese events from this period, previously available only in paper format, is crucial. In line with this goal, newly collected eyewitness accounts with existing observations for these events are presented, while macroseismic intensities are re-assigned in EMS98. Re-estimated epicentres suggest that the 1926 earthquake occurred further offshore, while the 1927 earthquake was on land at the southernmost tip of the Peloponnese peninsula. Isoseismal maps were created for both events using the Rossi-Forel and EMS98 scales. The use of modern unified European macroseismic scale (EMS98) in the study of historical earthquakes is essential for harmonizing the present and past with future hazard and risk analyses. The use of EMS98 wit

关键词： IL-33   ST2   carcinoma associated fibroblasts   regulatory T cells   head and neck squamous cell carcinoma   prognosis  

摘要： Background Interleukin-33 (IL-33) and Suppression of tumorigenicity 2 (ST2) expression are strongly associated with tumor growth and progression in diverse cancers, indicating the possibility of targeting the IL-33/ST2 axis pathway as a favorable therapeutic approach. However, the specific implications of IL-33/ST2 expression in Head and Neck Squamous Cell Carcinoma (HNSCC) prognosis are not fully understood. Thus, there is a need for more comprehensive research to verify the tasks and clinical significance of IL-33 and ST2 in HNSCC. Objectives The objective of this study was to evaluate the potential of differentially expressed IL-33 and ST2 in tumor tissues that could serve as novel biomarkers in HNSCC. Material & methods The Web of Science, Scopus, and PubMed electronic databases were searched and analyzed from January 2013 to July 2023. Results Nine studies fulfilling the inclusion criteria were analyzed. These selected studies were mainly having observational analytical study design, predominantly conducted within the Southeast Asian population. IL-33, primarily located in the stroma, demonstrates enhanced expression within carcinoma-associated fibroblasts (CAFs). Overexpression of IL-33 in CAFs correlates with its expression in tumor cells, as per some of these reports. Elevated IL-33 levels in CAFs are associated with unfavorable clinical outcomes. Increased IL-33 expression is related to poor nodal metastasis-free survival, indicating an adverse prognosis in HNSCC. In HNSCC, tumor cells and regulatory T cells (Tregs) expressed ST2. The degree of ST2 expression on Tregs corresponds to the abundance of IL-33 expressing CAFs. IL-33 increases the Tregs density and amplifies their suppressive capability. Poorer survival outcomes in HNSCC are linked to elevated ST2 expression in Tregs combined with the existence of IL-33-expressing CAFs. Conclusion CAF-driven cancer invasiveness relies on IL-33 signaling via paracrine and autocrine pathways. IL-33 may be a prognos