关键词： femtosecond transient absorption   excited-state intramolecular proton transfer   electronic resonance effects   energy relaxation pathways   photosensitization  

摘要： Hypericin from St. John's wort has been used as a potent photosensitizer, but its working mechanism remains elusive which hinders its rational design for improved functionality. We implement ultrafast spectroscopy and quantum calculations to track the excited-state dynamics in an intricate hydrogen-bonding network of hypericin in solution. Using femtosecond transient absorption (fs-TA), we track excited state intramolecular proton transfer (ESIPT) via a previously unreported blueshift of a long-wavelength stimulated emission (SE) band with excitation-dependent dynamics in various solvents, owing to the dominant Q(7,14) tautomer that undergoes bidirectional ESIPT. This finding is corroborated by ground-state femtosecond stimulated Raman spectroscopy (GS-FSRS) and density functional theory (DFT) calculations. Moreover, contrasting the neutral and anionic forms of hypericin enables us to reveal an intramolecular charge transfer step underlying ESIPT. We demonstrate UV and visible excitations as an integral platform to provide direct insights into the photophysics and origin for phototoxicity of hypericin. Such mechanistic insights into the excited state of hypericin will power its future development and use.

关键词： 工程项目   思想政治工作   国有企业  

摘要： 在当前市场环境下，国有企业工程项目员工思想政治工作面临着前所未有的挑战与机遇。文章深入分析了当前国有企业工程项目员工思想政治工作面临的挑战，针对这些挑战，提出了新形势下国有企业开展工程项目员工思想政治工作的创新策略，包括构建以项目为中心的思想政治工作体系、加强思想政治教育的针对性和实效性、培养和引进高素质的思想政治工作人才等。通过研究分析得出结论，新形势下国有企业工程项目员工思想政治工作应紧密结合项目特点，注重实践创新，强化专业队伍建设，以适应时代发展要求。

关键词： 烟草企业   融媒体时代   企业文化建设   高质量发展  

摘要： 在融媒体时代，信息传播格局发生重大变化，为烟草企业文化建设带来了新契机与新挑战。文章论述了融媒体时代烟草企业推动企业文化建设高质量发展的意义，剖析了当前烟草企业文化建设的现状与成因，探讨了融媒体时代烟草企业推动企业文化建设高质量发展的路径，包括从利用融媒体创新文化传播形式、打造个性化文化品牌、提升员工参与度、构建完善的融媒体传播体系等方面。

关键词： 企业文化   青年员工   思想政治认同  

摘要： 企业文化是青年员工思想政治认同的重要载体，其核心价值观传播和行为规范对青年员工思想政治认同形成有显著影响。文章结合企业文化与青年员工思想政治认同的交互现状，分析了企业文化影响青年员工思想政治认同的内在机制，并提出了优化路径。。

关键词： ACS   STEMI   pretreatment   ESC guidelines  

摘要： The 2023 ESC guidelines changed the previously recommended strategy of early treatment in patients with STEMI. Pre-treatment with a P2Y12 receptor inhibitor may be considered in patients undergoing a primary PCI strategy (Class IIb, Level of evidence B). However, the available scientific evidence justi- fies a personalized approach differentiating the indications for pre-treatment with oral P2Y12 receptor inhibitors depending on the concomitant administration of opioids. In our opinion, in patients undergoing primary PCI not treated with opioids, pre-treatment with an oral P2Y12 receptor inhibitor should be applied, while in patients undergoing primary PCI treated with opioids, pre-treatment with an oral P2Y12 receptor inhibitor should be considered.

关键词： 国有企业员工   思想政治工作   人文关怀   宣传引导  

摘要： 文章从深入分析新时期国有企业加强和改进员工思想政治工作的重大意义入手，提出国有企业要充分运用各种思想政治工作方法，从政治导向、问题导向、责任导向、舆论导向“四个方面”充分发挥思想政治工作强信心、暖人心、聚民心、筑同心的作用，加强和改进员工思想政治工作，使思想政治工作成果转化为企业高质量发展成效。