关键词： Left ventricular thrombosis   Soluble suppression of tumorigenicity 2   Cardiovascular magnetic resonance   Myocardial infarction   Prognosis  

摘要： Background Left ventricular thrombosis (LVT) after acute ST-segment elevation myocardial infarction (STEMI) is closely related to inflammation. Soluble Suppression of Tumorigenicity 2 (sST2) expressed as a novel inflammatory marker, has received much attention in recent years. However, the relationship between sST2 and LVT is unclear. This study aimed to investigate the correlation between sST2 and LVT formation after emergency PCI (pPCI) in STEMI patients. Methods 293 patients with STEMI who were tested for sST2 at admission within 24 h at the Affiliated Hospital of Xuzhou Medical University from June 2018 to August 2023 were consecutively enrolled and evaluated for myocardial infarction characteristics and the presence of LVT by cardiac magnetic resonance imaging (CMR). The diagnosis of LVT was defined as a left ventricular cavity in the late gadolinium enhancement (LGE) of CMR with a low signal intensity mass. Results A total of 38 patients developed LVT after STEMI, multivariable logistic regression analysis showed that sST2 [P = 0.002, OR = 1.01 (1.01 similar to 1.02)] an independent predictor of LVT formation. The results of the net reclassification index (NRI) and Integrated Discrimination Improvement Index (IDI) suggested that sST2 could improve the conventional model of LVT. A linear relationship between sST2 and LVT was fitted using a restricted cubic spline (RCS). Conclusions ST2 was independently associated with LVT formation after pPCI in STEMI patients, and sST2 improved the risk modeling of LVT.

关键词： Staphylococcus haemolyticus   bacteraemia   bloodstream infections   epidemiology   multi-drug resistance   neonatal infections   neonatal intensive care units   outbreak  

摘要： Background: Staphylococcus haemolyticus (SH) is an opportunistic pathogen associated with nosocomial infections, particularly bacteraemia in neonates. Epidemiological trends and genetic diversity of these infections worldwide are largely unknown. Aim: To investigate an increase in SH vascular catheter-related bacteraemia in neonates and describe the molecular epidemiology in France between 2019 and 2023. Methods: We analysed clinical and microbiological surveillance data from the French national surveillance network for central catheter-related (venous and umbilical) infections between 2019 and 2023. We also performed genomic and phylogenetic analyses of 496 strains isolated both inside (n = 383 from neonates, staff and environmental samples) and outside (n = 113 from adults) the neonatal intensive care unit (NICU) settings. Results: The proportion of SH among the 474 reported cases of nosocomial bacteraemia increased from about 20% to 30% over 5 years, mainly affecting very low birth weight preterm neonates (<= 1,500 g). The ST29 sequence type (ST) not prevalent in previous studies was predominant, accounting for 74% of NICU strains. ST29 was characterised by phenotypic multidrug resistance to at least six classes of antibiotics (oxacillin, quinolones, gentamicin, cotrimoxazole, clindamycin and rifampicin), which distinguished it with good sensitivity and specificity from other prevalent multidrug-resistant STs identified (ST1 and ST25). ST29 strains more frequently harboured the drfG, vgaLC and mupA genes and a triple point mutation (D471E, I527M and S532N) in the rpoB gene. Conclusions: The present study highlights the success of a highly resistant ST29 lineage in French NICUs mainly affecting very low birth weight premature neonates.

关键词： 国有企业   党建品牌   党建融合   企业竞争力   信息技术  

摘要： 文章分析了党建品牌建设对提升党建质量、增强企业凝聚力及提升企业竞争力方面的作用，探讨了当前党建品牌建设在品牌定位、活动内涵、工作方式和保障体系等方面存在的问题。进而提出，国有企业应围绕企业特色优势明确品牌定位，丰富活动内容增强品牌吸引力，运用现代信息技术创新工作方式，建立健全保障体系等有效策略，从而打造具有企业特色的党建品牌体系，彰显品牌引领效应，为企业高质量发展注入强大动力。

关键词： 全面深化改革   国有企业   思想政治工作  

摘要： 随着中国经济转型的深入推进和国有企业改革的不断深化，传统的思想政治工作模式面临诸多挑战。文章探讨了全面深化改革背景下国有企业思想政治工作存在的问题，包括思想政治工作与企业经营管理的融合不够紧密、工作方式方法缺乏创新以及思想政治工作队伍建设的滞后性等，进一步提出了推动思想政治工作与企业战略目标的协同发展、创新思想政治工作的方法以及加强思想政治工作者队伍建设等实践路径，旨在为新时代国有企业的思想政治工作提供理论支持与实践参考。