关键词： Central cord syndrome   Cervical spinal cord injury   Guidelines   Spinal cord injury without fracture or dislocation   Treatment  

摘要： Background: Guidelines for the management of acute spinal cord injury are based on a young age group suffering spinal fracture dislocations caused by high-impact trauma. The purpose of this study was to characterize our recent cervical spinal cord injury (cSCI) experience and compare it to this traditional demographic. We hypothesized that most cSCI patients now fall outside the scope of published guideline principles. Methods: Cross-sectional cohort study. A detailed review was performed of cSCI patients admitted to our level 1 trauma institution over a 12-month period identifying demographics, injury types, and coded diagnoses cross-referenced from multiple archival systems Results: Fifty-one patients with cSCI from blunt trauma were identified over the 1-year study period of which 82% did not have a spinal fracture or dislocation. cSCI patients without fracture/dislocation were older (mean age 62), had low-impact injuries (93%), and lower American Spinal Injury Association grades (98%). Patients with fracture/dislocation were younger (mean age 48), had high-impact injuries (77%), and higher American Spinal Injury Association grades (66%). Ninety-eight percent of our cSCI patients without fracture/dislocation presented with sensory and motor changes preferentially involving hands and arms in contrast to 11% of patients with fracture dislocation (P < 00001). Conclusions: cSCI patients without fracture/dislocation now represent the large majority of spinal cord injuries at our level I trauma center. The demographic is most consistent with central cord syndrome, implicating unique pathophysiology and natural history. Extrapolation of management principles from previous guideline efforts is not intuitively generalizable to this patient population. © 2025 The Author(s)

关键词： Alcohol   Beverage   Commercial   Sclerocarya birrea   South Africa  

摘要： The consumption of marula fruit (Sclerocarya birrea) beer has a long history in Southern Africa. For over 10,000 years, marula fruit beer has played a central role in the dietary, spiritual, and socio-cultural reality of low-income communities in South Africa, Zimbabwe, Namibia, Botswana, and the Kingdom of Eswatini. Given its high vitamin C content (two times the vitamin C content of oranges), antioxidants, and minerals, marula fruit, marula fruit juice, and marula fruit beer have been important sources of nutrients in rural areas. In recent decades, the production of marula fruit beer has transcended its cultural and social relevance, becoming a crucial economic driver by providing much-needed household income. Women have particularly benefited from the direct sale of the marula fruit to marula fruit liqueur producers such as Distell, and the informal trade of the beer to the local people. Seeing the potential to grow the market, a few marula fruit beer commercialisation attempts were made in the 1990s, albeit without much success. These past failures highlight the absence of comprehensive data on optimal standard processing procedures, nutritional composition, economic and export potential, societal relevance, microbial quality, and consumer safety. The consideration of each of these aspects is necessary for the successful commercialisation and market adoption of the beverage, locally and internationally. Thus, this study provided a comprehensive review of various aspects and properties that describe marula fruit beer fundamentally as an artisanal product with the potential to be a competitive exotic fruit alcoholic beverage in the niche market of fruit-based alcoholic drinks. © 2025 Elsevier B.V.

关键词： 绿色供应链   企业绩效   熵权-TOPSIS  

摘要： 绿色供应链旨在通过优化供应链各环节的资源利用和能源消耗,减少环境污染和碳排放。然而,绿色供应链的实施对企业绩效的影响并不完全清晰。本文以制造类企业中较具代表性的海尔智家为研究对象,基于以往学者在绿色供应链绩效评价体系的研究成果,从环境绩效、经济绩效和社会绩效三方面选取指标来构建评价体系,根据2020—2022年海尔智家相关年报数据,运用熵权-TOPSIS法对评价体系展开分析。研究结果表明,在不同发展阶段,绿色供应链的持续开展并非对企业各项绩效都有积极促进作用,其对环境绩效而言始终存在正向影响,对经济绩效而言存在震荡影响,对社会绩效而言存在间接正向影响。

关键词： 贸易经济   发展基于   政策环境   战略定位   技术创新  

摘要： 全球经济一体化发展进程全面加速,对我国企业贸易经济的长足发展而言,是一个利好消息。我国企业拓展贸易经济领域、开发国际市场的动力和热情也在不断高涨。在贸易经济发展过程中面临的政策机遇、环境机遇以及技术机遇,都能够为我国企业核心竞争力的提升搭建更坚实的平台支撑。但是抢抓机遇也是企业的一项战略任务,本文从带动企业盈利能力提升、强化企业风险应对能力、引导企业竞争实力的强化三个领域对贸易经济发展的意义进行了阐述,同时针对我国企业贸易经济的长足发展提出了三个关键策略:首先,明晰战略定位,转变贸易经济发展理念;其次,推动技术创新,优化贸易经济管理方法;最后,强化国际合作,关注国际市场全面拓展。

关键词： 市场营销   数字化时代   渠道整合   思念食品  

摘要： 数字化时代,网络营销、电子商务蓬勃发展,成了当代商品的重要营销渠道,多数企业虽然在经营过程中已看到数字化营销的优势及重要程度,但并未意识到将传统营销渠道与数字化营销渠道有机整合的必要性。基于此,本文全面分析了数字化时代企业市场营销渠道整合与优化策略,包括统一的顾客数据平台构建、跨渠道体验的无缝融合、加强技术基础设施建设和集成、跨部门协同和内部培训等多个方面。特别地,本文通过思念食品的案例分析,详细描述了企业如何通过技术创新和战略调整,实现市场营销渠道的有效整合,以期为企业提供实践中的指导。

关键词： 信息化   业财融合   企业管理   数据共享   ERP系统  

摘要： 在全球化竞争加剧、市场变化莫测的背景下,企业如何通过内部管理优化实现可持续发展成为重要课题。本文首先阐述了业财融合的内涵,分析了信息化对业财深度融合的推动作用及面临的挑战,进而探讨了面临挑战的原因,并提出了一系列优化策略,以期为企业管理实践提供参考。

关键词： 专精特新   数智化   TOE理论  

摘要： 在数字经济背景下,数智赋能已成为推动中小企业高质量发展的关键引擎。本文以安阳市专精特新企业为研究对象,通过深入分析数智赋能对安阳市专精特新企业高质量发展的影响机制、驱动路径,探讨如何通过数智化手段提升企业的技术创新力、市场竞争力及可持续发展能力。本文基于技术、组织和环境三个维度,结合TOE理论,从多个方面阐述数智赋能的作用机制,以期为安阳市专精特新企业高质量发展提供借鉴和参考。

关键词： 绿色贸易   纺织服装   绿色壁垒   循环经济  

摘要： 随着全球各个国家环保意识的增强,绿色贸易已成为国际贸易的重要趋势。纺织服装行业作为外贸的重要组成部分,面临着绿色贸易壁垒的挑战和机遇。本文旨在探讨绿色贸易背景下,外贸企业尤其是纺织服装行业企业如何实现可持续发展。通过分析绿色贸易壁垒的定义、特点及其对纺织服装行业的影响,探讨企业在绿色生产、循环经济等方面的实践路径。同时,提出外贸企业在绿色管理、市场多元化战略及绿色认证方面的可持续发展策略,以帮助企业更好地应对绿色贸易壁垒,实现可持续发展。

关键词： 中小企业   数字化转型   新质生产力   实地调研   西南地区  

摘要： 中小企业数字化转型是培育制造业企业新质生产力的必经之路,当前西部地区在推进转型过程中存在诸多挑战,通过对西南地区151家中小制造业企业数字化转型过程中的实践进行调研,发现企业存在缺乏专业人才、成本收益不确定、满足个性需求不充分等人、财、物三方面的困难,提出采取企业、服务商、融资机构共享转型成果的创新模式;对企业按行业、规模、地理位置等方面分类推进;以企业“转思想、用起来”作为考核和评价的指标;以及持续完善支持政策与人才保障措施的建议,进一步促进西南地区中小制造业企业数字化转型,加快发展新质生产力,提高企业在新经济形势下的可持续发展能力。

关键词： blakpc-14   Carbapenemase-producing Pseudomonas aeruginosa   Ceftazidime-avibactam-resistant   XDR-PA  

摘要： Objective: We studied two Klebsiella pneumoniae carbapenemase (KPC)-14 variants from clinical Pseudomonas aeruginosa isolates (C137 and C159) to better understand the genomic diversity, mechanisms, and genes that confer antibiotic resistance and pathogenicity. Methods: Genomic DNA from C137/159 was subjected to Illumina and Oxford Nanopore sequencing. Horizontal transmission of the plasmid was evaluated using cloning experiments. The expression of efflux pumps, the outer membrane protein OprD, and the enzyme AmpC was quantified using qRT-PCR. The detectability of KPC-14 was evaluated using different methods, and biofilm formation assays and growth curves were assessed. Results: C137 and C159, sequence type 463 ExoU-positive multidrug-resistant strains, were concurrently resistant to carbapenems and ceftazidime-avibactam. Both strains possessed five intrinsic antimicrobial resistance genes (fosA, catB7, crpP, bla_PAO, and a bla_OXA-486 variant) as well as bla_KPC-14. In strain C137, bla_KPC-14 was located on a plasmid (pC137). Both strains expressed the bla_KPC-14 gene, concurrent inactivation of OprD, overexpression of the MexX efflux pump, and a pronounced capacity for biofilm formation. The genomic environment of KPC-14 consisted of IS26/IS26/TnpR_Tn3/ISKpn27/ISKpn6/IS26, which classified it as pseudo-compound transposon (PCT). IS26-mediated PCTs may store a variety of resistance genes, including bla_KPC-2 and KPC variants, which are currently disseminating in this region. Conclusions: The KPC-14 variant presents significant challenges for clinical treatment. The bla_KPC-14 gene carried by PCTs was integrated into the chromosome and exhibited stability throughout bacterial inheritance. Our research highlights the need for improved clinical surveillance of KPC-producing P. aeruginosa. © 2025 The Authors