关键词： sequence type 283   invasive type   Streptococcus agalactiae   tetracycline susceptible  

摘要： Invasive infection by Streptococcus agalactiae (GBS) is a significant cause of death in newborn babies. In Thailand, data on strain distribution in GBS, specific virulence genes, and susceptibility patterns are limited. Therefore, our study aimed to establish the sequence type (ST) distribution and to use a specific virulence gene in combination with a susceptibility profile for strain identification. Non-duplicate 277 isolates of GBS were tested for ST, virulence genes, and antimicrobial susceptibility profiles. Twenty-five STs were detected. The ST283 (29.24%) and ST1 (27.07%) were the most common STs. The absence of the bca gene was an excellent marker to rule out ST283. All isolates were susceptible to nearly all tested antibiotics;however, only ST283 revealed 100% susceptibility to tetracycline, while ST1 and other non-ST283 showed 21.33 and 4.96%, respectively. Therefore, combining the alpha-C protein (bca) positive and tetracycline susceptible revealed 100% sensitivity for ST283. However, to identify the ST283, this combination revealed 78.9% specificity, which increased to 80.2% when erythromycin or azithromycin-susceptible was added. The bca positive combined with tetracycline and erythromycin susceptibility results were a simple tool for predicting ST283. The bca negative profile with tetracycline and macrolides resistance was commonly non-ST283. The information gained by this tool would benefit patient management.

关键词： 国有企业   基层党组织   党风廉政建设  

摘要： 文章阐述了国有企业基层党组织党风廉政建设的重要作用，分析了国有企业基层党组织党风廉政建设存在的问题，提出了国有企业基层党组织党风廉政建设的优化路径，即加强政治建设、强化责任担当、加强理想信念教育、完善工作机制、加强组织建设。

关键词： 国有企业   党员   思想政治教育  

摘要： 文章探讨了国有企业党员思想政治教育的重要性，针对国有企业党员思想政治教育中存在的问题，提出了构建“定制化”学习路径、“沉浸式”体验教育、“绩效化”考核激励及“智能化”管理平台等策略，旨在精准对接党员需求，深化学习体验，强化成果转化，提升管理效能，以全面优化国有企业党员思想政治教育体系。