关键词： 人力资源管理   企业战略目标   员工满意度   组织效能   附加价值   企业的管理   企业的核心竞争力   品牌形象  

摘要： 人力资源管理的有效实施不仅能提升企业的核心竞争力,还能通过改善员工满意度、增强企业凝聚力、提升品牌形象等途径为企业创造附加价值。企业人力资源管理的基本内容人力资源管理的核心内容是实现企业战略目标的关键支撑,涵盖多个相互关联的模块,这些模块共同构成了完整且有机的人力资源管理体系。在企业的管理实践中,各核心内容既相对独立运行,又紧密联系、相辅相成,有力推动着组织效能的提升。

关键词： 国有企业   保密管理   信息化建设  

摘要： 随着国家科学技术水平的不断发展和信息化程度的不断加深,国有企业的涉密信息和涉密人员数量不断增加,国有企业的保密管理要素和管理难度也在逐步增加,对于传统保密工作的人工管理模式和有限的管理资源来说,已经无法满足新时期保密工作日益增长的管理需求。因此,保密管理信息化建设对于新时期保密工作来说势在必行。本文通过对传统保密管理工作模式现状分析,指出其在管理效率、规范性、管理透明度等方面的不足,进而阐述国有企业单位保密管理信息化建设的重要性,为推进保密管理信息化建设提供实践指导。

关键词： Amino acid conjugation   Antiangiogenesis   Antimetastasis   Hypersialylation   Lithocholic acid   Sialyltransferase   ST6GAL1  

摘要： A series of LCA-aromatic amino acid conjugates were synthesized and tested for their inhibitory effects on N-glycan specific ST6GAL1 and O-glycan specific ST3GAL1. The LCA-amino acid conjugates with phenyl and indole moieties showed enhanced inhibitory activity and selectivity towards the N-glycan-specific ST6GAL1, with the indole-containing compound 4e exhibiting the highest activity (IC₅₀ = 20.0 ± 0.5 μM). In addition, compound 4e exhibited the highest antimetastatic potential, effectively inhibiting MDA-MB-231 cell migration at non-cytotoxic concentrations. Compound 4e also suppressed tumor growth and metastasis in vivo, attributing to its potential to disrupt integrins sialylation. The conjugate has also demonstrated excellent antiangiogenetic properties in vitro and ex vivo, owing to its ability to downregulate the VEGF/VEGFR2/Akt pathway. Taken together, these findings prove the practicality of employing LCA as a scaffold and aromatic amino acid conjugation in the discovery of novel, potent, and selective ST inhibitors necessary to address abnormal cell surface α-2,6-N-sialylation. © 2025 Elsevier Inc.

关键词： 建设资金来源   资金效益   资金成本   金融机构   经贸合作   政治化倾向   融资   贸易和投资  

摘要： 由于全球经济萎靡不振,逆全球化思潮不断涌现,一些发达国家经贸合作的政治化倾向越来越明显。面对变化的全球贸易和投资环境,我国金融机构亟需苦练内功,在国际市场站稳脚跟,为“走出去”企业提供更有力的金融支持。而“走出去”企业在拓展主业的同时,也应更加关注项目资金的结算和融通,这既可以确保项目建设资金来源的稳定可靠,又能够降低资金成本,实现应有的资金效益。

关键词： 环境规制   新《环境保护法》   企业绩效   双重差分模型  

摘要： 以2011至2022年间在我国A股上市的企业为研究样本,以新《环保法》实施为准自然实验,构建双重差分模型,探究其对上市企业绩效的影响效果。研究发现,新《环保法》能够显著促进上市企业绩效的提升,这一结论在经过一系列稳健性检验后依然成立;进一步探索影响机制发现,新《环保法》通过缓解企业外部融资压力激励企业绩效提升。异质性分析表明,新《环保法》能够显著促进成长期企业和大规模企业绩效的提升,但是政策对成熟期企业和小规模企业绩效的影响较弱。

关键词： Breccia   Heritage stone   Menderes Massif   Natural pozzolans  

摘要： The aim of this study is to determine the provenances of natural stone aggregates of the lime mortars from the St. Jean and Anaia Churches, which represent two of the most significant Byzantine buildings in Western Türkiye. With this aim, the characterization study was conducted to define the physical properties and raw material compositions of lime mortars;hydraulic properties of the binders;mineralogical and chemical compositions, microstructural properties of lime, binders and aggregates;geochemical characteristics and pozzolanic activities of aggregates. The analyses were determined using X-ray diffraction (XRD), scanning electron microscopy coupled with energy dispersive spectroscopy (SEM-EDS), and thermogravimetric analysis (TGA). Furthermore, field observations and analytical studies were paired with the characterization results to determine the possible provenances. Analytical studies demonstrated that natural stone aggregates exhibited highly pozzolanic properties, which imparted hydraulicity to lime mortars. The macrostructure of the natural stone aggregates exhibited angular characteristics and a diverse lithological composition derived from the older brecciated clastics of the Menderes Massif. The fine-grained volcanic matrix of the aggregates was predominantly dacitic or rhyolitic in character, possibly derived from a breccia matrix composed of volcaniclastic materials. The findings suggested that the provenance of the natural stone aggregates were the breccia accumulation regions around Ayasuluk (Selçuk) for the St. Jean Church and Söke-Germencik for the Anaia Church. The deliberate selection of natural stone sources to produce hydraulic lime mortars shows a conscious relationship with the surrounding geology during the Byzantine period. © The Author(s) 2025.

关键词： 复杂网络   农业企业   社团划分算法   风险传导  

摘要： 随着市场经济的持续深化,农业企业的风险传导日趋复杂。上市公司发生重大风险后,相关风险会蔓延至更多企业,这对于资金相对乏、抗风险能力较弱的农业企业打击更为剧烈。因此本研究采用了Leading Eigenvector、Louvain和Spinglass等社团划分算法,分析了农业股网络的拓扑结构和社团演化,揭示了农业股风险传导网络的动态演变特征。研究发现,2021年后农业股的社团结构从多社团模式逐渐演变为两大社团主导的风险传导集群,且风险传导速度呈现U型变化趋势,这与宏观事件的滞后效应相关。此外,节点中心性分析表明,不同企业在风险传播中的重要性和影响力存在差异。研究结果表明,宏观事件对农业股风险网络的影响存在缓冲期,随后风险传导速度加快,以期为企业、投资者和政策制定者在未来应对风险提供了具有参考价值的依据与启示。

关键词： Hemogram-derived ratios   Prognostic markers   Neutrophil-to-lymphocyte ratio   Myocardial infarction  

摘要： BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse *** the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient *** To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMI patients,potentially improving clinical *** A prospective,observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla,Bosnia and *** study included 170 patients with NSTEMI,who were divided into a group with MACE and a control group without ***,the MACE group was subdivided into lethal and non-lethal groups for prognostic *** hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was *** Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMI)patients with MACE and a control group at T1 and ***,significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes ***,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal ***,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%CI:0.727-0.859)and OR of 4.915(95%CI:1.917-12.602,P=0.001),emphasizing its important role as a prognostic *** This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI *** follow-up,NLR,PLR,and CRP/Ly off

关键词： Anti-inflammatory agents   Nitric oxide (NO)   NLRP3 inflammasome   Inflammatory bowel diseases (IBD)  

摘要： Herein, we designed and synthesized a series of novel bis-amide small molecule anti-inflammatory agents, among them, compound ST12 showed most potent anti-inflammatory activity. ST12 effectively inhibited the production of nitric oxide (NO) (inhibition rate of 52.67 +/- 0.03 % at 10 mu M) and downregulated the mRNA levels of proinflammatory cytokines iNOS, IL-6, IL-1(3 and TNF-alpha in lipopolysaccharide (LPS) induced RAW264.7 cells. Furthermore, mechanism studies suggest that compound ST12 exerted anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome. Importantly, ST12 effectively ameliorated DSS-induced colitis in vivo. Taken together, ST12 is worthy of further investigation as a small molecule anti-inflammatory agent for treatment of inflammatory bowel diseases (IBD).

关键词： 人工智能推理   专利分析   文献计量   系统性综述  

摘要： 中国和美国是人工智能专利申请最多的两个国家,推理是人工智能的核心和基座,可以通过对推理技术进展的研究来把握两国人工智能关键能力的水平。人工智能推理的本质是对思维过程的模拟或再造,将人的行为习惯、思维决策过程、事物或事件的节点及过程计算机程序化。中国的人工智能推理学术论文发文量和专利申请量从2021年开始超过美国。然而,从专利申请和授权情况来看,中国企业的表现并没有比美国企业更为突出,反而在知识推理、自动驾驶、实时交通分析等方面较为擅长。美国企业则在认知模型、神经推理、建筑、电网、人机交互等前沿方向上获得了不少专利授权。通过中美两国的分析比较,文章认为中国的各类研发主体应加强合作,拓宽技术研发范围,补足专利技术保护范围与地域布局的短板,努力推进政策规划中的前瞻性导向。