关键词： Brain   Injury   Trauma   Inflammation   Immune   Coagulopathy   Specific-pathogen free  

摘要： Severe traumatic brain injury (TBI) is a devastating injury with a mortality of similar to 25-30 %. Despite decades of high-quality research, no drug therapy has reduced mortality. Why is this so? We argue two contributing factors for the lack of effective drug therapies include the use of specific-pathogen free (SPF) animals for translational research and the flawed practice of single-nodal targeting for drug design. A revolution is required to better understand how the whole body responds to TBI, identify new markers of its progression, and discover new system-acting drugs to treat it. In this review, we present a brief history of TBI, discuss its system's pathophysiology and propose a new research strategy for the 21st century. TBI progression develops from injury signals radiating from the primary impact, which can cause local ischemia, hemorrhage, excitotoxicity, cellular depolarization, immune dysfunction, sympathetic hyperactivity, blood-brain barrier breach, coagulopathy and whole-body dysfunction. Metabolic reprograming of immune cells drives neuroinflammation and secondary injury processes. We propose if sympathetic hyperactivity and immune cell activation can be corrected early, cardiovascular function and endothelial-glycocalyx-mitochondrial coupling can be restored, and secondary injury minimized with improved patient outcomes. The therapeutic goal is to switch the injury phenotype to a healing phenotype by restoring homeostasis and maintaining sufficient tissue O-2 delivery. We have been developing a small-volume fluid therapy comprising adenosine, lidocaine and magnesium (ALM) to treat TBI and have shown that it blunts the CNS-stress response, supports cardiovascular function and reduces secondary injury. Future research will investigate its suitability for human translation.

摘要： 党的十八大以来,国家高度重视数字经济发展.大型公路交通行业正处在进入成熟市场的发展过程中,必须适应数字化、网络化、智能化发展趋势,推动面向用户中心化的敏捷模式转型、面向生态协同的生产模式转型、面向数据驱动下的运营模式转型、面向集约化的服务模式转型,催生新产业、新业态、新模式.

关键词： 金融科技   全要素生产率   异质性分析  

摘要： 金融科技在企业的发展过程中发挥重要作用。基于2013—2022年沪深A股上市企业数据，构建固定效应模型实证研究金融科技对企业全要素生产率的影响。结果表明：金融科技可以显著提高企业全要素生产率，结论在更换核心变量与滞后核心变量后依然成立。进一步研究发现，金融科技对非国有企业全要素生产率的影响相对于国有企业更显著。基于上述结论为企业应对金融科技带来的挑战和机遇提供建议。

关键词： Endocrine cancer   General surgery   Interventional cardiology   Ischaemic heart disease  

摘要： Phaeochromocytomas are rare catecholamine-secreting tumours, usually benign, originating from chromaffin cells of the adrenal glands. Their typical presentation includes the triad of headaches, sweating and tachycardia due to excessive catecholamine release. However, many patients do not exhibit all three symptoms, making diagnosis challenging. A significant proportion of cases (around 40%) are linked to genetic disorders. Cardiac complications, including life-threatening events, are *** report details the case of a 43-year-old woman presenting with chest pain, headaches and diaphoresis. Initial ECG showed an anterolateral ST-elevation myocardial infarction pattern, but coronary angiography revealed no arterial disease. The left ventricular angiogram indicated apical ballooning. Elevated blood pressure prompted suspicion of phaeochromocytoma, which was confirmed through positive metanephrine *** tumour, located in the right adrenal gland, was successfully removed laparoscopically, and pathological examination confirmed the *** should be suspected in patients with unexplained myocardial infarction, labile hypertension and normal coronary arteries, as beta-blockers can be harmful if used in untreated cases.

关键词： 业财融合   房地产企业   资源配置   优化路径  

摘要： 本文首先阐述房地产企业开展业财融合的重要性,包括提升财务管理效率、优化资源配置和推动管理创新;其次指出房地产企业业财融合应用现状,包括业财融合深度不足、财务人员对业务理解有限以及业财融合机制不健全;最后针对这些问题,提出具体的解决策略,如深化业财融合、提高财务人员业务能力、完善业财融合机制和强化风险管控等,旨在为房地产企业实施业财融合提供理论支持和实践指导,进而提升企业的管理水平和经济效益.

关键词： 分拆上市   企业并购   经济效果  

摘要： 本文通过分析A公司从B公司分拆后再并购B公司这一案例,对企业分拆上市后再并购母公司的动因及影响展开研究.首先简要介绍案例背景,其次对B公司分拆A公司的动因,以及A公司从B公司分拆和上市后的财务绩效进行简要分析,然后阐述A公司并购B公司的动因及市场反应,最后从并购目标的适配性、利益相关者的可接受性、并购的可行性、商业伦理四个维度对并购进行总体评价.得出以下启示:企业并购需要明确并购目的,选择合适时机进行并购,并购后还应密切关注企业间的协同效应及其整合效果.