关键词： 复杂网络   农业企业   社团划分算法   风险传导  

摘要： 随着市场经济的持续深化,农业企业的风险传导日趋复杂。上市公司发生重大风险后,相关风险会蔓延至更多企业,这对于资金相对乏、抗风险能力较弱的农业企业打击更为剧烈。因此本研究采用了Leading Eigenvector、Louvain和Spinglass等社团划分算法,分析了农业股网络的拓扑结构和社团演化,揭示了农业股风险传导网络的动态演变特征。研究发现,2021年后农业股的社团结构从多社团模式逐渐演变为两大社团主导的风险传导集群,且风险传导速度呈现U型变化趋势,这与宏观事件的滞后效应相关。此外,节点中心性分析表明,不同企业在风险传播中的重要性和影响力存在差异。研究结果表明,宏观事件对农业股风险网络的影响存在缓冲期,随后风险传导速度加快,以期为企业、投资者和政策制定者在未来应对风险提供了具有参考价值的依据与启示。

关键词： Hemogram-derived ratios   Prognostic markers   Neutrophil-to-lymphocyte ratio   Myocardial infarction  

摘要： BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse *** the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient *** To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMI patients,potentially improving clinical *** A prospective,observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla,Bosnia and *** study included 170 patients with NSTEMI,who were divided into a group with MACE and a control group without ***,the MACE group was subdivided into lethal and non-lethal groups for prognostic *** hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was *** Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMI)patients with MACE and a control group at T1 and ***,significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes ***,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal ***,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%CI:0.727-0.859)and OR of 4.915(95%CI:1.917-12.602,P=0.001),emphasizing its important role as a prognostic *** This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI *** follow-up,NLR,PLR,and CRP/Ly off

关键词： Caribbean   Connectivity   Island hydrology   Ridge to reef   Streamflow   Watershed  

摘要： Study region: The island of St. Croix in the U.S. Virgin Islands, Lesser Antilles. Study focus: Small islands worldwide have limited water resources and an increased need to understand the mechanisms underlying island water budgets, but they also usually lack adequate data. Our study focused on the Salt River watershed on the island of St. Croix in the Virgin Islands, which is an ephemeral stream network comprising both volcanic and carbonate hydrogeology. We used hydrometeorological and soil moisture data at upstream and downstream sites (chosen by geospatial topographic and soil information) to characterize thresholds for runoff generation and to analyze the disrupted connectivity of the ephemeral stream network. New hydrological insights for the region: We found evidence of runoff thresholds, which align with work in similar catchments elsewhere. Connectivity from headwaters to lowland areas was uncommon, and saturation-excess overland flows and subsurface stormflow appeared to dominate runoff events. The upstream subcatchment (with volcanic hydrogeology) was much more responsive (runoff coefficient = 0.237) than the entire catchment (with partly carbonate hydrogeology;runoff coefficient = 0.086). The transition between these hydrogeologic zones may disrupt connectivity and play an important role in aquifer recharge, while buffering the marine environment from water quality problems. For resource managers, this study offers the possibility of identifying sensitive groundwater recharge zones, and provides insight into the frequency of ridge-to-reef flow events. © 2025

关键词： 人工智能推理   专利分析   文献计量   系统性综述  

摘要： 中国和美国是人工智能专利申请最多的两个国家,推理是人工智能的核心和基座,可以通过对推理技术进展的研究来把握两国人工智能关键能力的水平。人工智能推理的本质是对思维过程的模拟或再造,将人的行为习惯、思维决策过程、事物或事件的节点及过程计算机程序化。中国的人工智能推理学术论文发文量和专利申请量从2021年开始超过美国。然而,从专利申请和授权情况来看,中国企业的表现并没有比美国企业更为突出,反而在知识推理、自动驾驶、实时交通分析等方面较为擅长。美国企业则在认知模型、神经推理、建筑、电网、人机交互等前沿方向上获得了不少专利授权。通过中美两国的分析比较,文章认为中国的各类研发主体应加强合作,拓宽技术研发范围,补足专利技术保护范围与地域布局的短板,努力推进政策规划中的前瞻性导向。

关键词： Anti-inflammatory agents   Nitric oxide (NO)   NLRP3 inflammasome   Inflammatory bowel diseases (IBD)  

摘要： Herein, we designed and synthesized a series of novel bis-amide small molecule anti-inflammatory agents, among them, compound ST12 showed most potent anti-inflammatory activity. ST12 effectively inhibited the production of nitric oxide (NO) (inhibition rate of 52.67 +/- 0.03 % at 10 mu M) and downregulated the mRNA levels of proinflammatory cytokines iNOS, IL-6, IL-1(3 and TNF-alpha in lipopolysaccharide (LPS) induced RAW264.7 cells. Furthermore, mechanism studies suggest that compound ST12 exerted anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome. Importantly, ST12 effectively ameliorated DSS-induced colitis in vivo. Taken together, ST12 is worthy of further investigation as a small molecule anti-inflammatory agent for treatment of inflammatory bowel diseases (IBD).

关键词： 民营企业党建   民营企业生命力   促进企业健康发展  

摘要： 民营企业党建可以有效提高民营企业生命力,然而由于一些历史和现实的原因,不管是民营企业,还是我们党组织都未能充分重视。在全球经济衰退的背景下,民营企业党组织应该尽快转变工作思路,不断总结归纳民营企业急难愁盼的问题,以民营企业生存和发展面临的突出问题为导向开展党建工作。在促进企业健康发展上同民营企业结成统一战线,同民营企业出资人共同破解民营企业高质量发展难题和生命周期短难题,不断提高民营企业生命力,为建设社会主义现代化国家贡献力量。

关键词： 理论与实践   事业单位绩效评估   公共服务领域   优化与创新   公共服务职能   绩效评估体系   提升绩效   服务质量  

摘要： 事业单位在我国公共服务领域涉及教育、医疗、文化、科研等多个重要方面,其运行效率和服务质量直接关系到广大人民群众的切身利益。绩效评估作为一种有效的管理工具,能够对事业单位的工作表现进行系统、客观的评价,为改进管理、提升绩效提供依据。然而,目前部分事业单位的绩效评估体系仍存在一些不足,难以充分发挥其应有的作用,迫切需要进行优化与创新。通过深入探讨事业单位绩效评估体系的优化与创新路径,分析当前事业单位绩效评估体系存在的问题,结合相关理论与实践经验,提出构建科学合理的评估指标体系、创新评估方法、加强结果应用等一系列优化与创新措施,以此促进事业单位提升绩效,更好地履行公共服务职能,为社会发展作出更大贡献。

关键词： Methicillin-resistant Staphylococcus aureus ST398   Plasmids   Resistome   SCCmec  

摘要： Methicillin-resistant Staphylococcus aureus (MRSA) ST398 is a well-known livestock MRSA (LA-MRSA) in Europe. Notably, it has been increasingly detected in China recently. Food serves as a significant reservoir for S. aureus, and its transmission ability of MRSA ST398 remains to be explored in China. Recently, we screened four MRSA ST398 isolates from food sources in Shanghai, China, and subsequently performed whole-genome sequencing to identify their resistome and transmission potential. Phylogenetic analysis of these four MRSA ST398 isolates and other ST398 strains from China revealed that food serves as a significant vector for MRSA transmission among humans. Moreover, the four isolates in our study and infection-borne strains were classified within Clade 4.1, indicating their close genetic relationship. The most common antimicrobial resistance genes in Clade 4.1 isolates were mecA, blaZ, and ermC. Specifically, all mecA genes were located on SCCmec elements, which were excised from the genomes at a frequency of approximately 1 × 10⁻⁵. By prediction in silico, 88.5 % of the blaZ and 74.4 % of the ermC genes were located on mobilizable plasmids. Overall, these findings indicated that SCCmec and plasmids are critical drivers for resistome transmission of MRSA ST398. Consequently, targeting mobile genetic elements could serve as an effective strategy for preventing the spread of antimicrobial resistance in S. aureus. © 2025

关键词： Mortality   NSTE-ACS   Revascularization   Risk stratification   Women  

摘要： Objective: Previous works have struggled to clearly define sex-specific outcomes based on initial management in NSTE-ACS patients. We examined if early revascularization (<24 h) versus conservative strategy impacts differently based on sex and age in stable NSTE-ACS patients upon hospital admission. Methods: We identified 8905 patients with diagnosis of non‐ST elevation acute coronary syndromes (NSTE-ACS) in the ISACS-TC database. Patients with cardiac arrest, hemodynamic instability, and serious ventricular arrhythmias were excluded. The final cohort consisted of 7589 patients. The characteristics between groups were adjusted using inverse probability of treatment weighting models. Primary outcome measure was all-cause 30-day mortality. Risk ratios (RRs) with their 95 % CIs were employed. Results: Of the 7589 NSTE-ACS patients identified, 2450 (32.3 %) were women. The data show a notable reduction in mortality for the older women (aged 65 years and older) undergoing early invasive strategy compared to those receiving an initial conservative (3.0 % versus 5.1 %;RR: 0.57;95 % CI: 0.32 – 0.99) Conversely, younger women did not exhibit a significant association between early invasive strategy and mortality reduction (2.0 % versus 0.9 %;RR: 2.27;95 % CI: 0.73 – 7.04). For men, age stratification did not markedly alter the observed benefits of an early invasive strategy over a conservative approach in the overall population, with reduced death rates in both older (3.1 % versus 5.7 %;RR: 0.52;95 % CI: 0.34 – 0.80) and younger age groups (0.8 % versus 1.7 %;RR: 0.46;95 % CI: 0.22 – 0.94). These age and sex-specific mortality patterns did not significantly change within subgroups stratified by the presence of NSTEMI, or a GRACE risk score>140. Conclusion: Early coronary revascularization is associated with improved 30-day survival in older men and women and younger men who present to hospital in stable conditions after NSTE-ACS. It does not confer a survival advantage in yo

关键词： 档案信息   事业单位管理   快速检索   信息技术   纸质档案   决策制定   信息化手段   服务质量  

摘要： 随着信息技术不断发展,事业单位档案管理工作迎来了新的发展契机,但也面临诸多挑战。信息化背景下,档案管理信息化建设成为提升事业单位管理效率、优化服务质量、实现资源共享的必然选择。通过信息化手段,能够将传统的纸质档案转化为数字化形式,实现档案信息的快速检索、高效利用与长期保存,更好地为事业单位的决策制定、业务开展以及社会服务提供有力支持。