关键词： age and growth   American Eel   disease and parasites   life history   population dynamics  

摘要： Objective: Little is known about American Eel Anguilla rostrata populations across much of the species' large geographic range. This study aimed to collect important information on the life history and population biology of American Eel in a northeast Florida river. Methods: During two 12-week periods, from August to November 2021 and September to December 2022, American Eel were collected from a similar to 90-km stretch of the lower St. Johns River via boat electrofishing. Data on length, weight, age, Anguillicoloides crassus parasite infection, and swim bladder condition were recorded for American Eel collected in both years, and additional data on sex, sexual maturity, and fin and eye morphology were recorded for American Eel collected in 2022. Result: Overall, biologists spent more than 63.5 h of effort over 42 sampling days to collect 297 American Eel, ranging in size from 150 to 705 mm total length (TL) with a continental age ranging from 0 to 8 years. American Eel catches were low and varied by section of river and over time;however, no differences in the length-weight relationship or size structure were observed between river sections. Adult parasites were observed in swim bladders of 36% of American Eel, and 57% of eel exhibited some level of swim bladder damage. Although length-weight relationships were similar regardless of swim bladder condition, relative swim bladder length was lower for fish with severe damage. Histological examination of gonads from 160 American Eel in 2022 revealed that the male : female sex ratio was 0.9:1 and nearly all eel were sexually immature. The majority of fish were 2-4 years of age;average growth was modeled with a von Bertalanffy curve for American Eel aged 1-8: TL = 740 x [1 - e(-0.12(age + 1.98))]. Conclusion: Given the paucity of information about American Eel in this region, the data provided in this study will be critical to informing future decisions on the management of the American Eel stock.

关键词： vaccine   randomized clinical trials   adaptive designs   Phase 3   estimand  

摘要： Vaccines are crucial for protecting health globally;however, their widespread use relies on rigorous clinical development programmes. This includes Phase 3 randomized controlled trials (RCTs) to confirm their safety, immunogenicity, and efficacy. Traditionally, such trials used fixed designs with predetermined assumptions, lacking the flexibility to change during the trial or stop early due to overwhelming evidence of either efficacy or futility. Modern vaccine trials benefit from innovative approaches like adaptive designs, allowing for planned trial adaptations based on accumulating data. Here, we provide an overview of the evolution of Phase 3 vaccine trial design and statistical analysis methods from traditional to more innovative contemporary methods. This includes adaptive trial designs, which offer ethical advantages and enable early termination if indicated;Bayesian methods, which combine prior knowledge and observed trial data to increase efficiency and enhance result interpretation;modern statistical analysis methods, which enable more accurate and precise inferences;the estimand framework, which ensures the primary question of interest is addressed in a trial;novel approaches using machine learning methods to assess heterogeneity of treatment effects;and statistical advances in safety analysis to evaluate reactogenicity and clinical adverse events. We conclude with insights into the future direction of vaccine trials, aiming to inform clinicians and researchers about conventional and novel RCT design and analysis approaches to facilitate the conduct of efficient, timely trials. This paper provides an overview of the evolution of Phase 3 vaccine trial design and statistical analysis methods from traditional to more innovative contemporary methods.

摘要： 坚持党的领导、加强党的建设是国有企业的"根"和"魂".甘肃省农村信用社联合社(以下简称省农信联社)党委深入学习贯彻习近平新时代中国特色社会主义思想,旗帜鲜明提出强党建、促发展、化风险、严整改、抓合规、增效益、真关爱"21字"工作总要求,将"强党建"作为首要职责,深入实施省委"五大工程"和"党建112强基工程",以"红色引擎"推动甘肃农信深化改革和高质量发展.

摘要： 党的二十届三中全会对进一步全面深化改革、推进中国式现代化作出系统部署,把"坚持党的全面领导"摆在进一步全面深化改革必须贯彻的重大原则首位,强调要把党的领导贯穿改革各方面全过程,确保改革始终沿着正确政治方向前进.坚持党的领导、加强党的建设是国有企业的"根"和"魂",是改革发展的根本保证.要坚持把党的建设作为统揽全局的总抓手,持之以恒抓基层、打基础,纵深推进国企改革深化提升行动,使党建工作与企业发展同频共振、互融共进,以高水平党建引领企业高质量发展,用改革发展成果检验党建工作成效,为企业高质量发展筑牢红色堡垒.

摘要： 阿联酋卫星运营商耶赫卫星公司和地理空间情报提供商巴亚纳特完成合并,组建太空42航天科技公司.新公司市值约30亿美元,目标是打造天地连通性与地理空间综合服务,满足自动驾驶汽车等新需求.阿联酋政府已承诺,2043年前至少采购其51亿美元宽带服务.此前,耶赫卫星公司和巴亚纳特曾联手从芬兰冰眼公司订购了7颗主要面向阿联酋用户的合成孔径雷达卫星.

关键词： 数字化转型   企业发展质量   人力资本结构   创新质量   内部控制质量  

摘要： 数字化转型是新时代中国企业发展质量提升的内在要求和重要着力点。通过构建包括数字化转型投入的异质性企业模型,运用中国A股上市公司数据,实证检验了数字化转型对企业发展质量的影响效应。研究显示,数字化转型对企业发展质量具有显著的提升作用,是新时代中国企业竞争力提升的重要驱动力;人力资本作为企业数字化转型的重要支撑,其结构优化正向调节了数字化转型对企业发展质量的积极影响。机制分析表明,数字化转型通过影响企业创新和内部控制驱动企业发展质量提升;异质性分析表明,产权性质、管理架构等内部属性和产业性质、地理区位等外部环境是数字化转型影响企业发展质量异质性表现的重要因素。

关键词： 铬矿资源   地质特征   生产消费   企业投资   需求预测  

摘要： 铬是一种重要的基础性矿产资源，主要用于不锈钢的生产，已先后被美国、欧盟、日本、俄罗斯等国家或组织列入关键矿产名录。明确全球铬矿资源特征、供需形势及企业竞争等情况，对全球铬矿行业可持续发展和我国铬资源相关政策制定、涉矿企业海外投资具有积极意义。基于2014—2023年铬矿相关历史数据，采用数据统计及部门预测等方法对近十年全球铬矿资源特征、供需形势及企业竞争进行了梳理分析。全球铬矿床主要有层状和豆荚状两种类型，且铬矿资源全球分布高度不均，主要集中在哈萨克斯坦、南非和土耳其等国。南非近十年铬矿产量占全球总产量稳定在45%左右，是全球铬矿第一生产大国。我国近十年铬矿消费量增长94.9%，是全球第一消费大国，但自身资源禀赋极差，铬矿消费严重依赖进口，主要进口来源国为南非，进口集中度偏高。通过部门预测法预测2025年、2030年和2035年全球铬矿需求量分别为3904.0万t、4310.2万t和4530.1万t，未来全球铬矿需求保持强劲，且需求主要来自中国和以印度为代表的东南亚新兴工业国家。当前，全球铬矿资源竞争激烈，已初步形成以欧亚资源、嘉能可等矿业公司为主的寡头垄断局面，我国铬矿海外投资体量偏小，在全球铬矿市场竞争中处于劣势。为满足未来国内铬矿需求，我国应以不同方式加大在资源条件较好的南非和哈萨克斯坦的铬矿项目投资。

关键词： 新质生产力   市场准入负面清单   市场竞争效应   制度性成本效应  

摘要： 培育和提升企业新质生产力，是加快推进我国新旧动能结构转换，推动实现中国式现代化的重要途径。本文采用2013—2022年沪深A股上市公司数据，利用市场准入负面清单试点这一准自然实验，考察放宽市场准入对企业新质生产力的影响。研究发现，放宽市场准入能够促进企业新质生产力提升，具体表现为，相比未受政策影响地区的企业，受到政策影响地区企业的新质生产力提升幅度约为1.42%。机制分析表明，放宽市场准入对企业新质生产力的提升作用，主要通过市场竞争效应和制度性成本效应来实现。异质性研究发现，放宽市场准入对企业新质生产力的影响在公司治理水平较低和融资约束可能性较高的企业中更高。最后，在放宽市场准入的制度背景下，企业新质生产力的提高有利于促进企业投资价值提升。相关结论不仅能够深化现有研究关于放宽市场准入赋能作用的理论认识，还能够为我国加快培育和提升新质生产力带来政策启示。

关键词： CCTA   CT-MPI   NSTEMI  

摘要： Coronary CT angiography (CCTA) and dynamic stress CT myocardial perfusion (CT-MPI) are established modalities in the analysis of patients with chronic coronary syndromes. Their role in patients with suspected non-ST elevation myocardial infarction (NSTEMI) is unknown. CCTA with CT-MPI might assist in the triage of NSTEMI patients to the Cath lab. We investigated the correlation of significant epicardial lesions by CT-MPI in addition to CCTA compared to invasive coronary angiography (ICA) with fractional flow reserve (FFR) in patients with NSTEMI. Twenty NSTEMI patients scheduled for ICA were enrolled in this study with planned ICA. CCTA and CT-MPI was performed pre-ICA. For each coronary artery, the presence or absence of significant lesions was interpreted by CCTA with CT-MPI, using an FFR of <= 0.8 or angiographic culprit (stenosis > 90%, suspected plaque rupture) as reference. The main outcome was the per-vessel correlation. Sixteen out of 20 patients had a culprit lesion that required immediate revascularization. CCTA with >= 50% stenosis demonstrated a per vessel sensitivity and specificity for the detection of significant stenosis of respectively 100% (95% CI: 86-100%) and 75% (95% CI: 58-88%). CCTA with CT-MPI showed a lower sensitivity 90% (95% CI: 70-99%) but higher specificity of 100% (95% CI: 90-100%). CCTA with CT-MPI exhibits a strong correlation for identifying significant CAD in patients with NSTEMI. Thereby, it might assist in the triage of ICA in NSTEMI patients.

关键词： Heritage   space   Black communities   Bristol  

摘要： This article explores Black heritage spaces in St Pauls, Bristol and investigates how Black urban communities use inner-city landscapes and neighbourhoods for the production and celebration of own heritage spaces. While the city has been the site of an important demonstration of public contestation of authorised heritage, when the statue of slave trader Edward Colston was toppled on 7 June 2020, there has been a history of Black heritage practices and spaces. Using ethnographic methods, such as participant observation, chatting, walking through the neighbourhood and participating in local events, the article examines these alternative heritage spaces, where Black heritage is produced, (re-)defined and presented by the community who actively remember, recognise and celebrate their legacies in the urban space.