课程文献中心 更多>>

关键词： Binding modes   Interfaces   Genetics   Chemical structure   Conformation  

摘要： Protein-protein interactions play a key role in mediating numerous biological functions, with more than half the proteins in living organisms existing as either homo- or hetero-oligomeric assemblies. Protein subunits that form oligomers minimize the free energy of the complex, but exhaustive computational search-based docking methods have not comprehensively addressed the challenge of distinguishing a natively bound complex from non-native forms. Current protein docking approaches address this problem by sampling multiple binding modes in proteins and scoring each mode, with the lowest-energy (or highest scoring) binding mode being regarded as a near-native complex. However, high-scoring modes often match poorly with the true bound form, suggesting a need for improvement of the scoring function. In this study, we propose a scoring function, KFC-E, that accounts for both conservation and coevolution of putative binding hotspot residues at protein-protein interfaces. We tested KFC-E on four benchmark sets of unbound examples and two benchmark sets of bound examples, with the results demonstrating a clear improvement over scores that examine conservation and coevolution across the entire interface.

摘要： Motivation: Since its launch in 2010, *** has become an important tool for the annotation and cross-referencing of Life Science data. In 2016, we established the Compact Identifier (CID) scheme (prefix: accession) to generate globally unique identifiers for data resources using their locally assigned accession identifiers. Since then, we have developed and improved services to support the growing need to create, reference and resolve CIDs, in systems ranging from human readable text to cloud-based e-infrastructures, by providing high availability and low-latency cloud-based services, backed by a high-quality, manually curated resource. Results: We describe a set of services that can be used to construct and resolve CIDs in Life Sciences and beyond. We have developed a new front end for accessing the *** registry data and APIs to simplify integration of *** CID services with third-party applications. We have also deployed the new *** infrastructure in a commercial cloud environment, bringing our services closer to the data.

关键词： 条形码   数字信息   数字对象唯一标识符   网址   互联网信息   DOI   唯一标识   信息标注  

摘要： 数字对象唯一标识符(digital object identifier,DOI)是对包括互联网信息在内的数字信息进行标识的一种工具。在传统的出版物中,书刊、磁带、光盘都有国际标准编号(ISBN、ISSN、ISCN)及其条形码,作为出版物的唯一标识。这些标识使出版物得到有效的管理,便于读者查找和利用。而网上的文档一旦变更了网址便无从追索。数字信息标注DOI如同出版物的条形码,是一个永久和唯一的标识号。

关键词： IOS开发体系   用户身份标识符   信息安全  

摘要： 移动互联网广告平台为了实现个性化推送,会从多种渠道搜集海量的用户信息,这些平台获取到用户一系列精准信息的关键在于各个环节对用户身份的标识进行匹配。本文将跟踪研究IOS开发体系下,用户身份标识符的机制原理以及境内外数据服务商对于苹果自有用户身份标识符的替代方案情况,对目前互联网企业及数据服务商利用标识符采集用户信息,开展精准营销的行为开展信息安全风险分析并提出监管建议,对信息安全监管及相关从业人员具有一定的指导意义。

关键词： 标识符   信息技术   DOI   数字对象唯一标识   Object   规范化管理   唯一性   互联网  

摘要： DOI,即数字对象唯一标识,为英文Digital Object Identification的缩写。根据国际标准ISO 26324里的解释,它的意思是“一个对象的数字标识符”。这个标识符具有唯一性、永久性的特点。DOI是规范化管理、组织、共享、利用数字资源的有效工具。随着信息技术和互联网的发展,DOI目前已在国际出版界得到广泛推广应用。

关键词： IP地址   隐私保护   地址隐私   身份隐私   加密  

摘要： 【目的】IP地址作为网络层的唯一标识符,已经成为网络追踪和隐私关联分析的基础信息。区别于其它个人可识别标识,耦合了身份与位置隐私的IP地址作为路由寻址必备信息,不得不暴露在IP报文头部,从而难以采用终端侧的混淆技术消除IP隐私泄露风险。【方法】为了保护IP隐私,本文提出了一种终端设备与网络设备协同的IP隐私保护技术方案。【结果】在该方案中,网络设备对IP地址等隐私信息进行实时混淆,能够达到逐包级的IP隐私保护,防止隐私好奇者通过窃听或收集IP报文来实施隐私攻击。该技术在同时兼顾隐私保护、路由高效寻址、审计追踪等需求的情况下,不但消除当前IP地址耦合身份和位置双重语义的障碍,而且还对身份标识符和位置标识符分别进行加密保护。【结论】本文的技术可以对IP隐私进行较好的保护,具有很高的潜在实用价值。

关键词： 数字对象标识符   数字化期刊   文献类型   数字化传播   杂志内容   DOI   网络链接   标注规则  

摘要： 数字对象标识符(digital object identifier,DOI)是对包括互联网信息在内的数字信息进行标识的一种工具。为了实现杂志内容资源的有效数字化传播,同时保护这些数字资源在网络链接中的知识产权和网络传播权,为标识对象的版权状态提供基础,实现对数字对象版权状态的持续追踪,本杂志纸版期刊和数字化期刊的论文全部标注DOI。即除科普和消息类稿件外,其他文章均需标DOI。由编辑部为决定刊载的论文标注DOI。参照国际DOI基金会编码方案(美国标准ANSI/NISOZ39.84⁃2000)规定,标注规则如下:“DOI:统一前缀/学会标识.文献类型.cn+杂志cn号6位数字+收稿年月日(8位)+论文流水码(5位)。”

关键词： 数字信息   条形码   数字对象   网址   标识符   互联网信息   标注  

摘要： 数字对象惟一标识符(digital object identifier,D0I)是对包括互联网信息在内的数字信息进行标识的一种工具。在传统的出版物中,书刊、磁带、光盘都有国际标准編号(ISBN、ISSN、ISCN)及其条形码作为出版物的惟一标识。这些标识使出版物得到有效的管理,便于读者查找和利用。而网上的文档一旦变更了网址便无从追索。数字信息所标注的DOI如同出版物的条形码,是一个永久和惟一的标识号。

关键词： 数字对象   标识符   数字信息   条形码   互联网   惟一标识  

摘要： 数字对象惟一标识符(digital object identifier,D0I)是对包括互联网息在内的数字信息进行标识的一种工具。在传统的出版物中,书刊、磁带、光盘都有国际标准编号(ISBN、ISSN、ISCN)及其条形码,作为出版物的惟一标识。

摘要： Background Although previous studies have evaluated how the proportion of women in orthopaedic surgery has changed over time, these analyses have been limited by small sample sizes, have primarily used data on residents, and have not included information on growth across subspecialties and geographic regions. Question/purpose We used the National Provider Identifier registry to ask: How have the (1) overall, (2) regional, and (3) subspecialty percentages of women among all currently practicing orthopaedic providers changed over time in the United States? Methods The National Provider Identifier Registry of the Centers for Medicare and Medicaid Services (CMS) was queried for all active providers with taxonomy codes pertaining to orthopaedic subspecialties as of April 2020. Women orthopaedic surgeons were identified among all physicians with subspecialty taxonomy codes. As all providers are required to provide a gender when applying for an NPI, all providers with queried taxonomy codes additionally had gender classification. Our final cohort consisted of 31,296 practicing orthopaedic surgeons, of whom 8% (2363 of 31,296) were women. A total of 11,714 (37%) surgeons possessed taxonomy codes corresponding with a specific orthopaedic subspecialty. A univariate linear regression analysis was used to analyze trends in the annual proportions of women who are active orthopaedic surgeons based on NPI enumeration dates. Specifically, annual proportions were defined using cross-sections of the NPI registry on December 31 of each year. Linear regression was similarly used to evaluate changes in the annual proportion of women orthopaedic surgeons across United States Census regions and divisions, as well as orthopaedic subspecialties. The national growth rate was then projected forward to determine the year at which the representation of women orthopaedic surgeons would achieve parity with the proportion of all women physicians (36.3% or 340,018 of 936,254, as determined by the 2