Sukumar, Shravan Zhu, Xiaolei Ericksen, Spencer S. Mitchell, Julie C.
Univ Wisconsin Madison Dept Biochem Madison WI 53706 USAAnhui Univ Sch Life Sci Hefei 230601 Anhui Peoples R ChinaUniv Wisconsin Madison Small Mol Screening Facil Madison WI 53706 USAUniv Wisconsin Madison Dept Math Madison WI 53706 USA
摘要:
Protein-nucleic acid interactions are among the most important intermolecular interactions in the regulation of cellular events. Identifying residues involved in these interactions from protein structure alone is an important challenge. Here we introduce the webserver interface to DNA Binding Site Identifier (DBSI), a powerful structure-based SVM model for the prediction and visualization of DNA binding sites on protein structures. DBSI has been shown to be a top-performing model to predict DNA binding sites on the surface of a protein or peptide and shows promise in predicting RNA binding sites.