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关键词： Controllers  

摘要： In interventional surgery, the manual operation of the catheter is not accurate. It is necessary to operate the catheter skillfully and effectively to protect the surgeon from radiation injury. The purpose of this paper is to design a new robot catheter operating system, which can help surgeons to complete the operation with high mechanical precision. On the basis of the original mechanical structure-real catheter, the operation information of the main end operator is collected. After the information is collected, the control algorithm of the system is improved, and the BP neural network is combined with the traditional PID controller to adjust the PID control parameters more effectively and intelligently so that the motor can reflect the output of the controller better and faster. The feasibility and superiority of the BP neural network PID controller are verified by simulation experiments.

关键词： Microfluidics   Multiplexing  

摘要： Enzyme-linked immunosorbent assay (ELISA) is the gold standard method for protein biomarkers. However, scaling up ELISA for multiplexed biomarker analysis is not a trivial task due to the lengthy procedures for fluid manipulation and high reagent/sample consumption. Herein, we present a highly scalable multiplexed ELISA that achieves a similar level of performance to commercial single-target ELISA kits as well as shorter assay time, less consumption, and simpler procedures. This ELISA is enabled by a novel microscale fluid manipulation method, composable microfluidic plates (cPlate), which are comprised of miniaturized 96-well plates and their corresponding channel plates. By assembling and disassembling the plates, all of the fluid manipulations for 96 independent ELISA reactions can be achieved simultaneously without any external fluid manipulation equipment. Simultaneous quantification of four protein biomarkers in serum samples is demonstrated with the cPlate system, achieving high sensitivity and specificity (similar to pg/mL), short assay time (similar to 1 h), low consumption (similar to 5 mu L/well), high scalability, and ease of use. This platform is further applied to probe the levels of three protein biomarkers related to vascular dysfunction under pulmonary nanoparticle exposure in rat's plasma. Because of the low cost, portability, and instrument-free nature of the cPlate system, it will have great potential for multiplexed point-of-care testing in resource-limited regions.

关键词： Drops  

摘要： Microfluidic technology, as a method for manipulating tiny fluids, has the advantages of low sample consumption, fast reaction, and no cross-contamination. In a microfluidic system, accurate manipulation of droplets is a crucial technology that has been widely investigated. In this work, a self-powered droplet manipulation system (SDMS) is proposed to realize various droplet operations, including moving, splitting, merging, mixing, transporting chemicals and reacting. The SDMS is mainly composed of a triboelectric nanogenerator (TENG), an electric brush, and a microfluidic device. The TENG serves as a high-voltage source to power the system. Using different electric brushes and microfluidic devices, different manipulations of droplets can be achieved. Moreover, by experiments and simulations, the influence of the electrode width, the electrode gap and the central angle of one electrode on the performance of SDMS is analyzed in detail. Firstly, by using electrowetting-on-dielectric (EWOD) technology, SDMS can accurately control droplets for long-distance linear movement and simultaneously control multiple droplets to move in a circular electrode track consisting of 40 electrodes. SDMS can also manipulate two droplets of different components to merge and react. In addition, using dielectrophoresis (DEP) technology, SDMS can separate droplets with maximum volumes of 400 mu L and reduce the time of the complete mixing of two droplets with different components by 6.3 times compared with the passive mixing method. Finally, the demonstration shows that a droplet can be manipulated by hand power for chemical delivery and chemical reactions on a circular electrode track without an external power source, which proves the applicability of SDMS as an open-surface microfluidic device. Therefore, the self-powered droplet manipulation system proposed in this work may have great application in the fields of drug delivery, micro chemical reactions, and biological microanalysis.

关键词： 操作系统   工具箱   写本   孩子   小书   书名  

摘要： 2016年,我们动议、策划为儿童的研究写本小书,书名为《支持儿童研究行动100条》,把多年来带领孩子们一起学习、一起研究的小方法、小建议、小策略,借这本小书加以总结、提炼并表达、呈现出来。这本小书是为儿童研究赋能、加持的全新操作系统和思维工具箱。

关键词： 车载智能计算基础平台   操作系统   功能安全   评估框架  

摘要： 车载智能计算基础平台是汽车产业发展的重要基础和支撑重构下一代汽车电子产业链的关键纽带,安全问题至关重要。本文首先针对车载智能计算基础平台,从安全策略和系统设计两个层面进行功能安全分析;然后对平台的异构硬件、操作系统、开发工具链,分别研究提出功能安全要求;最后从流程、设计开发、测试验证三个层面,研究提出车载智能计算基础平台功能安全的评估框架。

关键词： Android操作系统   安全性   数字签名   木马病毒  

摘要： 本文主要就Android操作系统的特点和安全机制展开分析,并剖析其中存在的安全隐患,进一步提出优化改良措施,以求最大程度上保障用户信息安全。移动互联网用户数量不断增加,智能移动终端的功能也越来越强大,但功能多样的同时,意味着系统的安全性勉励这严峻挑战。Android操作系统作为主流移动终端操作系统之一,凭借其开放性特点,受到了各大移动设备生产厂商和用户的喜爱,但其安全性却始终受到诟病,自诞生起屡屡出现手机安全事件,严重侵害了用户的信息安全。因此对Android操作系统的安全性优化措施进行研究很重要。

关键词： 生态系统   操作系统   华为   大一统   OS   开发者   合力   面临挑战  

摘要： 自华为自有操作系统鸿蒙OS发布至今已经过去一年多的时间,最新统计显示,以鸿蒙OS作为"底座",华为目前已拥有180万开发者,HMS集成应用9.6万个,活跃用户数4.9亿,应用累计分发量2610亿,在体量上已经拥有与谷歌和苹果生态抗衡的能力。尽管如此,国内的主流手机厂商是否会采用鸿蒙OS及鸿蒙OS生态方面仍面临挑战,华为要最终实现其全场景、大一统的生态,真正成为全球第三大生态系统仍需产业合力。