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摘要： 高校图书馆作为重要的学术信息资源的服务机构,一直扮演着学术信息传播、知识普及与教学科研支持等多重角色.现今,传统图书馆服务模式逐渐被数字化、智能化的服务所取代,用户能够更便捷地获取信息资源.在此背景下,基于用户需求优化服务模式,已成为高校图书馆实现高效服务的重要方向.本研究旨在分析互联网环境下用户行为特征及需求,通过数据调研与案例分析,提出服务创新路径,以期为高校图书馆在互联网时代的转型发展提供理论支持与实践指导.

关键词： Cardiovascular disease   Carotid intima-media thickness   Carotid plaque   Metabolic syndrome  

摘要： Objective To investigate the effect of changes in metabolic syndrome status and persistence on carotid plaque risk. Methods This retrospective cohort study analyzed individuals who underwent routine health check-ups at the health management center of the Second Affiliated Hospital of Dalian Medical University from 2014 to 2023. Participants with at least three carotid ultrasound records meeting the inclusion criteria were classified into 4 groups based on changes in metabolic status: persistently metabolic health, transitioning from metabolic health to unhealth, transitioning from metabolic unhealth to health, and persistently metabolic unhealth. The cumulative incidence of carotid plaque in these groups was compared. A Cox proportional risk model was used to evaluate the relationship between changes in metabolic syndrome status, the number of metabolic syndrome components, and the risk of carotid plaque development. Restricted cubic spline analysis was applied to explore the association between changes in individual metabolic syndrome components and carotid plaque risk. Results Compared to the persistently metabolic health group, the persistent unhealth group had the highest risk of developing carotid plaque(HR=1.35, 95%CI 1.05-1.74, P=0.021), followed by those who transitioned from metabolic health to unhealth and those who improved from metabolic unhealth to health. Furthermore, the risk of carotid plaque increased progressively with the number of metabolic syndrome components. Restricted cubic spline analysis revealed a nonlinear relationship between fasting blood glucose change and carotid plaque risk, while systolic blood pressure, diastolic blood pressure, waist circumference, triglycerides, and high-density lipoprotein-cholesterol showed a linear dose-response relationship with carotid plaque. Conclusions The change of metabolic syndrome is associated with the risk of developing carotid plaque, and maintaining metabolic health, recovering from metabolic synd

关键词： 氟啶虫胺腈   乙基多杀菌素   芦笋   残留   长期膳食风险评估  

摘要： 为明确氟啶虫胺腈和乙基多杀菌素在芦笋上的残留膳食风险，分别开展了1年6地240 g/L氟啶虫胺腈悬浮剂和60 g/L乙基多杀菌素悬浮剂的规范残留试验。采用超高效液相色谱-串联质谱 (UPLC-MS/MS)，对氟啶虫胺腈和乙基多杀菌素及其代谢物在芦笋中的消解动态、残留水平和长期膳食摄入风险进行了评估。结果表明：在0.005~1.0 mg/kg 3个添加水平下，氟啶虫胺腈和乙基多杀菌素及其代谢物的平均回收率在86%~105%之间，相对标准偏差 (RSD) ≤11%，定量限均为0.005 mg/kg。氟啶虫胺腈和乙基多杀菌素的半衰期分别在1.1~1.9 d之间 和1.3~2.1 d之间，呈现较快的消解趋势;在3 d采样间隔期下，氟啶虫胺腈和乙基多杀菌素及其代谢物在芦笋上的残留量分别在<0.005~0.194 mg/kg之间和<0.01~0.041 mg/kg之间。长期膳食摄入风险评估结果表明，在平均膳食和97.5%分位值膳食消费量下，芦笋中氟啶虫胺腈和乙基多杀菌素残留量对一般人群长期膳食摄入风险的贡献率均不超过0.2%，说明通过芦笋摄入的氟啶虫胺腈和乙基多杀菌素残留对人体产生长期膳食摄入的风险较小。本研究为氟啶虫胺腈和乙基多杀菌素的合理使用提供了依据，为我国制定其在芦笋上的最大残留限量提供了基础数据。