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摘要： 多囊卵巢综合征是影响女性生育能力的常见疾病之一.据统计,5％～10％的育龄女性受到此病困扰.作为一种内分泌紊乱性疾病,多囊卵巢综合征不仅可能引起月经不调、体重增加、面部多毛等症状,更重要的是,它与女性生育能力有着密切的关系.那么,多囊卵巢综合征患者是否能够成功怀孕呢?这个问题困扰了不少女性患者及其家庭.

关键词： Acute lung injury   LuxS   Quorum sensing   Sepsis   Vibrio vulnificus  

摘要： Objective To investigate the effects of Vibrio vulnificus (Vv) quorum-sensing protein LuxS on the homeostasis of pulmonary innate immune cells in sepsis-induced acute lung injury. Methods This study constructed luxS knockout and complemented Vv strains. The time required for wild type, luxS knockout, and complemented Vv strains to grow to an absorbance of 600 nm in liquid medium was measured using a spectrophotometer. Iron-overloaded mice were intraperitoneally infected with 1×10⁵ CFU of the above three kinds of Vv strains, respectively. Clinical scoring for sepsis-induced dyspnea was used to evaluate the respiratory quality in mice. At 7 h after infection, the pathological changes in lung tissues were observed by HE staining;the bacterial loads in lung tissues were measured;the single-cell suspension of lung tissues was analyzed by flow cytometry. Uniform manifold approximation and projection (UMAP) was used to reduce the dimension of the distribution of CD45⁺ immune cells in lung tissues of mice in the PBS control group and infection groups with different strains. The frequency and absolute number of innate immune cells in lung tissues were analyzed by multicolor flow cytometry. One-way analysis of variance and t test were used for statistical analysis. Results There was no significant difference in the growth rate of wild type, luxS knockout, and complemented Vv strains in liquid medium. Compared with the mice infected with the wild type or complemented strain, the mice infected with the luxS knockout strain exhibited overall alleviated respiratory difficulty, decreased inflammatory cell infiltration in lung tissues, and reduced bacterial load in lung tissues (P<0.05). Besides, there was no significant difference in clinical respiratory scores, inflammatory cell infiltration, or bacterial loads between the mice infected with the complemented strain and wild type strain. UMAP analysis showed that compared with the mice infected with the luxS

关键词： wave-absorbing SiC fibers   fiber surface coating   stacking structure   computational optimization  

摘要： Structure modulation at multiscale is crucial for optimizing the electromagnetic wave absorption (EWA) properties of fiber-reinforced composites. Here we selected two types of wave-absorbing SiC fibers as reinforcements. The L-fiber had a relatively low resistivity of similar to 3 Omegacm and the H-fiber had a high resistivity of similar to 7x10(5)Omegacm. To adjust the impedance, BN single coating and SiO2/BN dual-coating were prepared respectively on the L-fibers. Unidirectional prepregs with different fibers were stacked in different rules to obtain the final composites. It showed that both the fiber coatings and stacking structure significantly influence the EWA performance of the composites. Guided by computational optimization, the stacked composites exhibited superior reflection loss (RL) lower than -10 dB across the whole X (8.2-12.4 GHz) and Ku (12.4-18.0 GHz) bands. It is interesting to find that the introduction of the surface coatings on the L-fibers significantly widens the available thickness range of the stacked composite for possessing excellent performance. In particular, dual-coating perform better in terms of broadening the available thickness range of the stacked composites.

关键词： 小学数学   习题设计   数概念   比较研究   教材开发  

摘要： 习题作为数学知识内化的核心载体,对学生的概念建构与思维发展具有关键作用.本研究以"万以内数的认识"为切入点,从习题数量、素材、类型、层次四个维度,系统比较人教版与新加坡Shaping Maths教材的差异.研究发现:新加坡教材通过大量基础性习题强化数概念记忆,符合行为主义学习理论;我国教材则侧重生活情境与综合应用,体现建构主义导向.基于认知发展理论与国际数学评估结果,文章提出"基础巩固与思维进阶并重"的教材优化路径,为小学数学教学改革提供借鉴.

摘要： "医生,我刚发现自己怀孕了,但一周前,我做了肺部X线检查.我该怎么办?检查对胎儿有影响吗?孩子还能要吗?"在产科咨询门诊,经常有孕妇来咨询类似的问题.这个问题没有统一的答案,让我们从影像学检查开始说起.

关键词： 小学数学   综合实践活动   跨学科   教学  

摘要： 在立德树人教育理念的指导下,教师积极促进数学与其他学科的融合,以满足新时代教育发展的要求.教师基于对学生基本认知能力的理解,在设计跨学科教学活动时,应致力于优化教学形式,精心选择教学内容,并合理规划教学流程,通过创设丰富多样的学习环境,为学生提供有力的学习支持,进而有效促进学生核心素养的全面发展,提升学生的问题解决能力.教师应积极组织跨学科的综合实践活动,加深学生对数学知识的理解.本文将详细探讨小学数学课程与综合实践活动相结合的跨学科教学价值及其具体的应用策略,旨在为相关教育工作者提供有益的参考和借鉴.