课程文献中心 更多>>

关键词： 肿瘤坏死因子-α   多囊卵巢综合征   氧化应激   胰岛素抵抗   肥胖   肠道菌群   高雄激素血症   肿瘤坏死因子-α抑制剂  

摘要： 多囊卵巢综合征（polycystic ovary syndrome，PCOS）是育龄期女性常见的生殖、内分泌、代谢性疾病，以排卵功能障碍、卵巢多囊样改变和高雄激素血症为主要特征，在一定程度上影响着患者的身心健康。近年来很多研究表明PCOS的发生发展与体内慢性低度炎症密不可分，肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）作为炎症因子可通过不同途径诱导PCOS的发生。基于此，TNF-α抑制剂也被用于治疗PCOS，部分患者也因此受益，但其属于超说明书用药，且目前研究较少。TNF-α抑制剂是否能够改善PCOS及其应用是否能够保障母婴安全等仍尚不明确。因此，本文将对TNF-α在PCOS发病机制中的作用以及其抑制剂在PCOS患者中应用疗效、安全性进行综述，以期为PCOS的发病机制的研究提供新线索，为PCOS临床治疗提供新思路。

关键词： Gamified learning   Grammar learning   Learning emotions   Learning outcomes   (sic)(sic)(sic)(sic)(sic)   (sic)(sic)(sic)(sic)   (sic)(sic)(sic)(sic)   (sic)(sic)(sic)(sic)  

摘要： This study examined the effects of gamified learning on first-time learners in Thai higher education, a group with no prior exposure to this pedagogical approach. Employing a mixed-method approach within a quasi-experimental design, the research involved a 10-week gamified grammar learning intervention (N = 144) for the experimental group (90.4% females and 9.7% males) and conventional grammar instruction for the control group (87.5% females and 12.5% males). Data collection included surveys, grammar tests, and reflective essays administered midway (cycle 1) and at the end of the English course (cycle 2). Quantitative data were subjected to descriptive and inferential statistical analyses, while qualitative data underwent thematic analysis. The findings revealed that gamified learning had dynamic effects over time on first-time learners, maintaining highly positive learning experiences;however, despite the presence of strong positive emotions and low negative emotions, these perceptions did not predict students' learning outcomes. This suggests that gamified learning may primarily influence learning experiences rather than learning outcomes. (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(90.4%(sic)(sic)(sic), 9.7%(sic)(sic)(sic))(sic)(sic)(sic)(sic)10(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(N =144), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(87.5%(sic)(sic)(sic), 12.5%(sic)(sic)(sic)).(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)((sic)(sic)(sic)(sic))(sic)(sic)(sic)(sic)((sic)(sic)(sic)(sic))(sic)(sic)(sic)(sic)(sic),(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic

关键词： 工业污水处理厂   化工废水   水解酸化   臭氧催化氧化  

摘要： 为解决化工园区综合工业污水处理问题,以南通经济技术开发区化工园区污水处理厂为例,对工业废水水质特点及处理设施效能进行研究,提出"预处理(分质处理)+二级处理(水解酸化+氧化沟+混凝沉淀)+深度处理(高级催化氧化+磁混凝高效沉淀池+反硝化滤池)+次氯酸钠消毒"的工艺路线,探讨了化工园区综合工业污水处理厂的部分设计要点,为国内类似化工园区的工业污水厂建设提供借鉴思路和案例参考.

关键词： 建筑工程造价   影响因素   降低工程造价   对策  

摘要： 随着我国城市现代化水平不断提升,建筑行业正在蓬勃发展,建筑项目激增,对施工质量和管理水平提出更高要求.工程造价管理成为企业绩效的重要评估标准.因建筑工程的复杂性,工程造价管理是综合系统工程,受多因素影响.为此,通过实际案例分析和全面评估建筑工程各阶段造价影响因素,并制定解决方案,包括优化设计、强化施工管理和构建专业化造价管理机构,以降低工程造价、提高经济收益和竞争力.