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The interaction of workplace noise, body mass index and systemic inflammatory response on hypertension

Liu, Mingsheng Wang, Feng Zhang, Shangyi Yao, Yong Chen, Zhenlong Yin, Wenjun

School of Public Health Hubei University of Medicine Shiyan 442000 ChinaMedical Examination Center Wuhan Prevention and Treatment Center for Occupational Diseases Wuhan 430015 ChinaDean's Office Wuhan Prevention and Treatment Center for Occupational Diseases Wuhan 430015 ChinaDepartment of Public Health Wuhan Prevention and Treatment Center for Occupational Diseases Wuhan 430015 China

来源详细信息

关键词： Body mass index Hypertension Interaction Noise, occupational Systemic inflammation

摘要： Objective To investigate the interaction of workplace noise, body mass index (BMI) and systemic inflammatory response on hypertension. Methods In January 2019, 1124 male workers from an automobile factory in Wuhan were selected by cluster random sampling method. The study population was divided into normal body weight group (BMI<24 kg/m²) and overweight group (BMI≥24 kg/m²) according to BMI, and were followed up for 3 years. The occupational health examination of the workers was carried out every year, blood routine and blood biochemical indexes were collected, and the information of the workers' age, BMI, type of work and age of exposure to injury were collected through field questionnaires. The noise intensity of the workplace of the enterprise was measured for 3 consecutive years, and the equivalent sound level was calculated according to the working time. Normal and skewness measurements were described by Mean±SD and [M (Q₁, Q₃) ], respectively. t-test or Wilcoxon rank sum test was used for inter-group comparisons. Categorical variables were expressed by frequency and percentage (%), and Chi-square test was used for inter-group comparisons. Mixed effects models and generalized estimation equations were fitted to analyze the relationship between occupational noise, systemic inflammation, and their interaction terms with blood pressure and hypertension risk. Results Univariate analysis revealed that the white blood cell counts, neutrophil counts, lymphocyte counts and eosinophil counts were positively associated with systolic blood pressure and diastolic blood pressure in overweight group (n=467), respectively (P<0.05). The participants with white blood cell counts≥5.94×10⁹/L, neutrophil counts≥3.31×10⁹/L, lymphocyte counts ≥2.03×10⁹/L, and eosinophil counts ≥0.12×10⁹/L had increased risk of hypertension by 52% (RR=1.52, 95%CI: 1.11-2.05), 37% (RR=1.37, 95%CI: 1.01-1.83), 58% (