关键词:
action mechanism
Biling Weitong Granules
canadine
chronic gastritis
kaempferol
molecular docking
network pharmacology
phenylalanine
quercetin
rutaecarpine
摘要:
Objective To discuss the mechanism of Beiling Weitong Granules in treatment of chronic gastritis by using network pharmacological technology and molecular docking. Methods The active components and predicted targets of Beling Weitong Granules were screened through TCMSP, TCMID, ETCM, and other databases and literature retrieval. The related targets of chronic gastritis were screened by GEO database, PharmGKB, GeneCard, and OMIM database. The “compound - drug - target - disease” network diagram and PPI network were constructed using Cytoscape 3.7.2 software. GO function and KEGG pathway were analyzed based on the David database, and the core components were molecule-docked with the target. Results A total of 182 active ingredients, 1 116 drug targets, and 3 443 disease targets were screened out. Key targets such as TNF, IL-6, Akt1, and TP53 were screened out according to the topological analysis results of “compound - drug - target - disease” network and PPI network. The core components of phenylalanine, quercetin, rutaecarpine, kaempferol, canadine were screened. There were 1 134 GO items and 186 KEGG channels with P < 0.05. Molecular docking showed that key targets were strongly correlated with core components. Conclusion Biling Weitong Granules treat chronic gastritis with effective ingredients such as phenylalanine, quercetin, rutaecarpine, and kaempferol. © 2025 Tianjin Press of Chinese Herbal Medicines. All rights reserved.