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关键词： Epidemiology   Immune evasion   Pathogenic mechanism   Severe fever with thrombocytopenia syndrome virus  

摘要： Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly pathogenic tick-borne bunyavirus that can cause severe viral hemorrhagic fever (SFTS), with a case fatality rate of up to 30%. SFTSV was first identified in 2010, which is primarily transmitted through tick bites but can also be transmitted to humans by sick people or infected cats and dogs. The main clinical manifestations of SFTS include high fever, gastrointestinal symptoms, thrombocytopenia, and leukopenia, with severe cases potentially resulting in death due to multi-organ failure. In 2017, the World Health Organization (WHO) listed SFTS as a priority disease with the potential to cause a public health emergency of international concern. SFTS cases have been reported in China, East Asia, and Southeast Asia, making it an important public health issue. In China, SFTS cases have been reported in 27 provincesincluding Henan, Hubei, Shandong, Anhui, Liaoning, Zhejiang, and Jiangsu. Additionally, SFTS cases have been identified in East and Southeast Asian countries such as South Korea, Japan, Vietnam, Myanmar, Thailand, and Pakistan. This review summarizes the epidemiology and pathogenesis of SFTSV, providing a basis for better understanding the mechanisms of immune evasion and developing effective countermeasures. © 2025 Editorial Office of Modern Preventive Medicine. All rights reserved.

关键词： β-榄香烯   乳腺癌   细胞凋亡   细胞侵袭   耐药   增敏   免疫功能   并发症  

摘要： 乳腺癌在全球范围内女性恶性肿瘤发病率排名首位.化学药物能杀灭肿瘤细胞、降低癌灶转移复发、提高患者的生存率,但其产生的不良反应、耐药性也制约了患者用药疗效和适用范围.β-榄香烯是从郁金中提取的倍半萜类化合物,可通过抑制肿瘤细胞生长和增殖、诱导肿瘤细胞凋亡、抑制肿瘤细胞侵袭和转移、逆转肿瘤药物耐药、协同化疗增强疗效、协同放疗增敏等作用机制治疗乳腺癌,同时在临床上通过调节机体免疫功能减轻不良反应、联合靶向药物增强临床疗效、抑制癌细胞转移降低并发症发生风险治疗乳腺癌.综述了 β-榄香烯治疗乳腺癌的作用机制和临床应用的研究进展,以期为 β-榄香烯治疗乳腺癌提供参考.

关键词： 黄芩苷   脑缺血再灌注损伤   炎症反应   氧化应激   细胞凋亡   缺血性脑水肿   细胞增殖   肠道微生物群   孕酮  

摘要： 脑缺血再灌注损伤是脑血管疾病主要的病理特征.黄芩苷可通过降低炎症反应,减轻氧化应激反应,抑制神经组织细胞凋亡,减轻缺血性脑水肿,促进神经细胞增殖,调节肠道微生物群,增强孕酮活性降低脑缺血再灌注损伤,对神经功能发挥保护作用.总结了黄芩苷对脑缺血再灌注损伤保护的研究进展,为黄芩苷的临床应用提供循证支持.

关键词： 水土流失   综合防治措施   生态系统服务功能   评估  

摘要： 随着社会的发展,人们对环境保护的关注不断加深.环境保护部门正全力推进生态环境的治理与修复.通过生态系统的自我调节能力利用、自然资源的理性开发及可持续发展的理念学习,以实现人与自然的和平共处.从水土保持和生态修复的角度出发,确保了施工的环境友好性,达到了生态保护和可持续发展的要求,改善了区域生态环境.

关键词： 高压氧   病毒性肺炎   呼出气一氧化氮   中文版莱切斯特咳嗽量表  

摘要： 目的探讨高压氧（HBO）对病毒性肺炎（VP）后咳嗽等后遗症状的改善作用。方法选择2022年12月至2023年12月济南市第八人民医院和山东省公共卫生临床中心收治的病毒性肺炎患者100例，按照随机数字表法，分为对照组（50例）和观察组（50例）。在常规治疗基础上，对照组给予普通氧疗，观察组给予HBO治疗。2组患者均在入组前及治疗半个月后测量中文版莱切斯特咳嗽问卷（LCQ）、血气分析、呼出气一氧化氮（FENO）、白细胞介素-6（IL-6）和T淋巴细胞亚群的变化。结果LCQ结果比较，观察组患者生理维度、心理维度及总评分分别为（5.46±1.41）分、（4.76±0.85）分和（13.23±2.32）分，均高于本组治疗前及对照组治疗后，差异均有统计学意义（均P<0.05）。观察组FENO、IL-6分别为（19.78±5.26）×10-6、（3.07±1.08）pg/ml，均低于本组治疗前及对照组治疗后，差异均有统计学意义（均P<0.05）。氧分压、血氧饱和度分别为（61.02±5.04）mmHg和（92.33±4.78）mmHg，均高于本组治疗前及对照组治疗后，差异均有统计学意义（均P<0.05）。T淋巴细胞亚群比较，观察组患者治疗后CD3％、CD4％和CD4/CD8分别为（54.13±8.81）%、（31.87±9.65）%和1.17±0.15，均较本组治疗前及对照组治疗后升高，差异均有统计学意义（均P<0.05）；CD8%治疗前后差异无统计学意义（P>0.05）。结论HBO能降低VP患者气道高反应性，减轻咳嗽、咳痰症状，纠正缺氧，提高免疫功能，改善生活质量。

关键词： community engagement   ecosystem services   mine rehabilitation   mine tailings   mineral extraction   stakeholder engagement   社区参与   生态系统服务   矿区修复   尾矿   矿产开采   利益相关方参与  

摘要： The growing global demand for minerals presents economic opportunities for countries such as the Philippines but also raises concerns about the impacts of mineral extraction on local communities and ecosystem services. This study explores an interdisciplinary community engagement process informing mine rehabilitation in the Philippines, framed through an ecosystem services lens. As part of the PROMT (Philippines Remediation of Mine Tailings) project, we conducted an initial participatory workshop at the Padcal Mine site, engaging Indigenous communities to assess local perspectives on ecosystem services and the impacts of mining activities. Through video presentations, a questionnaire, and focus groups, we found that 88% of participants understood the concept of ecosystem services after viewing an introductory video, while 62% believed mining negatively affected ecosystem services. Interestingly, 65% felt that rehabilitated mines could provide future ecosystem services, such as agriculture or ecotourism. Gender differences were evident, with women perceiving more significant mining impacts but being more optimistic about the rehabilitation potential. This underscores the importance of inclusive engagement approaches. The ecosystem services framework effectively bridges ecological knowledge with community priorities and tangible benefits, promoting social acceptance of mine rehabilitation. This interdisciplinary approach, particularly the integration of Indigenous perspectives, remains underused in mining contexts. Our community-based participatory methodology provides guidance for balancing diverse socioeconomic and environmental considerations. 全球矿产需求的增长为菲律宾等国家带来经济机遇, 同时也引发了对社区和生态系统服务影响的担忧。本研究通过生态系统服务的视角, 展示了一个指导矿区复垦的跨学科社区参与过程。作为菲律宾尾矿修复项目 (PROMT project) 的一部分, 我们在帕德卡尔矿区与原住民社区开展了初步的参与式座谈会, 评估当地对生态系统服务和采矿影响的看法。通过视频展示、问卷调查和焦点小组讨论, 我们发现88%的参与者在观看介绍视频后理解了生态系统服务的概念, 62%的参与者认为采矿对生态系统服务产生负面影响。65%的参与者认为经过修复的矿区可以提供未来的生态系统服务, 如农业或生态旅游。研究发现存在性别差异:女性认为采矿影响更大, 但对修复潜力持更积极态度, 这凸显了包

关键词： 马尔堡病毒   口岸防控   对策  

摘要： 马尔堡病毒(Marburg Virus,MARV)致死率高、传染性强,可感染人和非人灵长类动物导致马尔堡病毒病(Marburg Virus Disease,MVD).尽管我国尚未有马尔堡病毒病的报道,但仍需加强对马尔堡病毒病的监测与研究.本文围绕马尔堡病毒病的病原学、流行态势、流行病学特征、致病机制、实验室检测、疫苗与治疗药物的研发等进行综述.同时,针对旅行者提出了个人防护措施建议,并对口岸应对马尔堡病毒病疫情提出防控对策与建议.