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关键词： Applied and Technical Physics   Theoretical   Mathematical and Computational Physics   Complex Systems   Condensed Matter Physics   Atomic   Molecular   Optical and Plasma Physics  

摘要： This paper investigates bending responses of three-phase multi-scale hybrid laminated nanocomposite reinforced axisymmetric circular/annular plates based upon the three-dimensional poroelasticity theory for various sets of boundary conditions. The two-parameter elastic foundation (Pasternak type) is developed by taking into account the torsional interaction. Using compatibility conditions, the sandwich structure with two, three, five, and seven layers is modeled. The state-space-based differential quadrature method is presented to examine the bending behavior of the composite structure by considering various boundary conditions. For prediction of the bulk material properties of the multi-scale composite, Halpin-Tsai equations and fiber micromechanics are presented. The carbon nanotubes are supposed to be randomly oriented and uniformly distributed through the matrix of epoxy resin. Afterward, a parametric study is done to present the effects of stacking sequence, various types of sandwich circular/annular plates, linear and torsional gradient elastic foundation, and Biot's coefficient on the bending characteristics of the composite structure. Results reveal that the impact of external pressure on the hoop shear stress, radial stress, and radial shear stress of the laminated circular plate becomes more considerable in the middle layers.

关键词： carcinoma   signet ring cell   survival   treatment   uterine cervical neoplasm  

摘要： Rationale: Primary signet ring cell carcinoma of the uterine cervix is extremely rare and the clinical characteristics and prognosis are not well known and there are no specific guidelines for treatment. Patient concerns: A 43-year-old woman was referred to our hospital for abnormal uterine bleeding lasting 1 month. Diagnoses: Histological examination revealed a signet ring cell carcinoma of the uterine cervix. After evaluation of extragenital origin, the patient was diagnosed International Federation of Gynecology and Obstetrics stage IIIC1 primary signet ring cell carcinoma or the uterine cervix. Intervention: The patient was prescribed concomitant chemo-radiation followed by intracavitary brachytherapy. Outcomes: She showed no evidence of disease after treatment but, it recurred after 7 months of last treatment. Lessons: Different approaches to diagnosis and treatment of this rare disease are needed and molecular pathological studies related to the onset of the disease are required.

关键词： adrenergic receptor   β3AR   overactive bladder   mirabegron   receptor activation   ligand selectivity   cryo-EM   G-protein-coupled receptor   NanoBiT-G-protein dissociation assay  

摘要： The beta(3)-adrenergic receptor (beta(3)AR) is predominantly expressed in adipose tissue and urinary bladder and has emerged as an attractive drug target for the treatment of type 2 diabetes, obesity, and overactive bladder (OAB). Here, we report the cryogenic electron microscopy structure of the (beta(3)AR-Gs signaling complex with the selective agonist mirabegron, a first-in-class drug for OAB. Comparison of this structure with the previously reported (beta(3)AR and beta(3)AR structures reveals a receptor activation mechanism upon mirabegron binding to the orthosteric site. Notably, the narrower exosite in beta(3)AR creates a perpendicular pocket for mirabegron. Mutational analyses suggest that a combination of both the exosite shape and the amino-acid-residue substitutions defines the drug selectivity of the beta(3)AR agonists. Our findings provide a molecular basis for beta(3)AR subtype selectivity, allowing the design of more-selective agents with fewer adverse effects.

关键词： 道路桥梁   伸缩缝   施工技术  

摘要： 我国经济在近些年取得了良好的发展,这从很大程度刺激了建筑行业。当前国民经济发展主力产业就是建筑行业,建筑行业为我国经济发展做出了较大贡献。在建筑行业中,市政路桥施非常重要的组成内容,对交通运输安全和便利性有决定性作用,所以,相关工作人员需要加强重视市政路桥工程项目。高度重视影响市政路桥工程的力学、自然条件、温度等因素,对市政路桥施工中的伸缩缝技术加强应用和管控,充分发挥伸缩缝的价值,将市政路桥工程质量全面提升,从而为居民创造更加便利安全的交通条件。

关键词： 充填隔墙   滤水装置   接顶率   安全隐患  

摘要： 针对矿山进路充填过程中,充填多余水无法及时排出,导致部分进路不接顶、个别充填隔墙倒塌、灰浆外溢污染大、现场管理难等问题进行了分析,提出在砌筑充填隔墙时预留滤水装置的办法,不但解决了充填接顶率低、矿石贫化严重、墙体滤水性差、支护成本费用高、安全隐患多等问题,而且减少灰浆溢流量、提高充填体质量、节约了采矿成本,为矿山生产经营降本增效做出了贡献。

关键词： 人行为   部分时间部分空间   建筑节能   问卷调研  

摘要： 建筑中人员在室行为及用能模式是影响建筑能耗的重要因素。人员在室情况"部分时间部分空间"使用模式与连续运行的"全时间全空间"模式相比,会造成空调、采暖能耗显著差异。为了综合反映建筑中的人员在室时空特性,本研究提出了定量刻画人员在室"部分时间部分空间"特征的指标,人员在室部分时空比(Occupancy Part Time Part Space Ratio,OPPR),并对我国城镇住宅进行了入户的问卷调查,利用调研数据分析了城镇住宅建筑中人员在室时空特性及OPPR指标的分布特点、相关因素。最后,本研究对人员在室OPPR与空调系统运行ACPPR的对比分析进行了应用和讨论。

关键词： 伸缩缝   施工技术   市政道路   施工应用  

摘要： 随着我国经济与科技的不断发展,我国城市化进程也在不断推进中,城市的发展促进了公共交通事业的发展,而市政道路工程就是公共交通事业的一部分,该工程的建设与完善能够有效改善城市的道路交通情况,提升居民的生活质量。伸缩缝施工是市政道路工程中非常重要的施工内容,但是受到外界因素以及人为因素的影响,当前伸缩缝施工中存在较多的问题。本文将从伸缩缝施工技术在市政道路施工应用相关概述、常见的伸缩缝类型以及伸缩缝技术的应用要点三个方面进行相关论述,以供参考。

关键词： 地基基础   施工技术   桩基础  

摘要： 近些年来,随着我国社会经济的进一步发展以及城市常住人口的增多,高楼大厦这种新型建筑不仅降低了城市常住人口的压力和负担,也极大的提升了人们的物质文化水平和对生活品质的追求。高层建筑及超高层建筑的快速涌现,使得建筑物的自重和使用荷载显著增大,而地基是建筑物稳定的根基所在,这就使得地基基础方案的设计和技术选择需要更加严格和更加创新。桩基础作为一种深基础类型,应用最为广泛。

关键词： 有机更新   老旧社区   功能分区  

摘要： 现如今,城市中的老旧社区在现代城市新区的不断发展中,产生了一系列的问题。例如老旧社区发展缓慢与时代的要求相差巨大、居住环境条件落后无法保证居民生活质量、功能不够完善无法满足居民生产生活需求、道路狭窄管线外露存在安全隐患、老旧社区内部风貌与肌理新旧割裂等,这些现实问题已经阻碍了老旧社区的发展。老旧社区有机更新的发展策略如何制定,以及如何既满足当代需求又满足未来的可持续发展,如何解决老旧社区风貌、肌理的新旧割裂问题,历史文脉的延续与发展问题,是目前老旧社区面临的改造难题。基于有机更新理论,探讨老旧社区的更新与发展策略,有利于解决老旧社区的一系列现实问题,实现老旧社区的发展。