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关键词： 肺结核   涂阳   二线抗结核药物  

摘要： 目的了解2010-2012年惠安县疾病预防控制中心结核门诊涂阳肺结核患者二线抗结核药物（secondline antituberculosis durgs,SLD）使用情况,为该县制定合理使用SLD提供参考资料。方法应用自行设计的《惠安县登记治疗肺结核患者信息调查表》,根据2010-2012年惠安县疾病预防控制中心涂阳结核病患者病案资料进行回顾性调查,对患者基本情况、SLD使用情况及影响因素进行分析。结果初治患者741例,复治患者116例,使用SLD肺结核患者治疗成功率为79.88%,未使用SLD肺结核患者治疗成功率为87.15%,两者的差异有统计学意义（P〈0.01）;影响SLD使用的因素为X线有无空洞、治疗分类、病变部位涉及肺野严重程度和性别（均有P〈0.05）。结论涂阳肺结核患者在未进行药敏试验或者结果未报告之前,应该选择标准的化疗方案进行治疗,避免不规范使用二线抗结核药物（SLD）。

关键词： 人行天桥   列车风   舒适度  

摘要： 列车运行会引起强烈的列车风,不仅会危及站台候车人员及沿线工作人员的人身安全外,也会对路边建筑物或沿线隔离栅墙等施加脉动风载,基于某铁路跨线人行天桥的工程实例,借鉴前列车风荷载模型的研究成果,研究列车风对该跨线人行天桥桥梁的影响,为人行天桥列车风作用下的舒适度研究奠定基础。

关键词： 三线企业   随迁子女   教育   重庆  

摘要： 随着三线企业的搬迁,大批职工子女内迁重庆。因资金、校舍、设备、教师编制等条件所限,大多数三线企业无法解决其随迁子女的入学教育问题。重庆市委与重庆市教育局通过扩大班级学额挖公办学校的潜力、积极发动三线企业筹办职工子弟学校、鼓励三线企业委托其附近有条件的学校代办职工子弟班等方式灵活解决了三线企业随迁子女的入学教育问题。

关键词： Bevacizumab   Recurrent ovarian cancer   Secondary cytoreductive surgery   Response to second-line chemotherapy  

摘要： Objective. To evaluate the timing and pattern of relapse, and duration of response to second line chemotherapy in advanced ovarian cancer (AOC) patients treated with first line carboplatin-paclitaxel chemotherapy with or without bevacizumab. Patients and methods. This is a case-control study including 222 AOC patients. Seventy-four women treated with first line carboplatin-paclitaxel-bevacizumab chemotherapy (Cases) were matched based on laparoscopic predictive index value, and residual tumor at first surgery with 148 AOC patients treated with carboplatin-paclitaxel. Distribution of pattern of relapse, and response to second line chemotherapy was compared between the two groups. Time to Progression (TTP) for second line chemotherapy was also analyzed for study purpose. Results. Median platinum-free interval (PFI) was 16 months (range 2-65) in Cases, compared with 9 months (1-83) in Controls (p-value = 0.001). Twenty patients (51.3%) among Cases showed recurrence in multiple anatomic sites, compared with 31 (31.9%) in the Control group (p-value = 0.035). Peritoneal recurrence occurred as diffuse in 30 Cases (96.8%), and 60 Controls (82.2%;p-value = 0.046). Secondary cytoreductive surgery (SCS) was successfully completed in 53.5% of Controls compared to 10.0% of Cases (p-value = 0.016). In women with fully platinum-sensitive relapse, response rate to second line chemotherapy was 85.2% in Controls, compared to 38.4% in Cases (p-value = 0.002). Finally, Cases showed a shorter TTP, compared to Controls (5 months vs 8 months;p-value = 0.041). Conclusions. Incorporation of bevacizumab into upfront regimens prolongs PFI in AOC patients, but is associated with wider presentation of relapse, lower rate of complete SCS, and shorter TTP to second line chemotherapy in women with platinum-sensitive disease. (C) 2016 Elsevier Inc. All rights reserved.

关键词： Insulin-like growth factor-1   natural killer cells   miR-486-5p   hepatocellular carcinoma   immunotherapy   perforins   NKG2D   NKG2A  

摘要： In this study, an impaired natural killer (NK) cell cytolytic activity in 135 hepatocellular carcinoma (HCC) patients parallel to a reduced expression level of insulin-like growth factor (IGF)-1 in NK cells of HCC patients has been revealed. Ectopic expression of miR-486-5p, a direct upstream regulator of IGF-1, restored the endogenous level of IGF-1 in NK cells of HCC patients, thus augmenting its cytolytic activity against Huh7 cells in an opposite manner to the IGF-1 siRNAs. Unorthodoxly, over-expression of miR-486-5p in target hepatocytes resulted in the repression of IGF-1, suppression of Huh7 cells proliferation and viability in a similar pattern to the IGF-1 siRNAs. Therefore, this study highlights a potential role of IGF-1 in modulating cytolytic potential of NK cells of HCC patients. miR-486-5p acts in a cell-specific manner, differentially modulating IGF-1 expression in NK cells and their target hepatocytes with a contemporary inhibitory impact on HCC progression.

关键词： Brittle fracture  

摘要： Centerline segregation occurs as a positive concentration of alloying elements in the mid-thickness region of continuously cast slab. Depending upon its severity, it may affect mechanical properties and potentially downstream processing such as weldability, particularly for high-strength line pipe. The segregation fraction in continuously cast slabs and corresponding hot-rolled strips was assessed on API 5L grade X65 line pipe steels with different levels of segregation, rated as Mannesmann 2.0 and 1.4. The results showed that the segregation fraction in hot-rolled strip samples was in accordance with that assessed in the cast slabs, and the segregated regions in hot-rolled strip samples were found to be discontinuous. Transverse and z-direction CVN impact tests were conducted on the two strips and the results showed that centerline segregation does have an influence on the Charpy impact properties of line pipe steel. Specimens located at segregated regions exhibited lower Charpy impact toughness and strips rolled from slabs with higher segregation levels are more likely to exhibit greater variability in Charpy impact toughness. The influence of centerline segregation on z-direction Charpy impact toughness is more severe than on transverse Charpy impact toughness. Lower Charpy impact toughness and brittle fracture surface with cleavage facets along with rod-shaped MnS inclusions were observed for the strip rolled from slab with 2.0 segregation rating if the Charpy specimens were located at segregated regions. The influence on Charpy impact toughness can be associated with the pearlite structure at the centerline and level of MnS inclusions.

关键词： wall   magnetic induction   perfect conductor   Spin wave  

摘要： Equations for vector lines of the magnetic field and magnetic induction of a spin wave propagating perpendicularly to an external magnetic field in a dielectric-ferrite-dielectric structure tangentially magnetized to saturation and bounded on both its walls by a perfect conductor or a perfect magnetic wall are obtained. The vector line patterns of these magnetic quantities are calculated for the case when one of the dielectrics is a vacuum half-space. It is shown that the spin wave in a ferrite plate and in such structures may be considered as vortices of magnetic induction propagating in time and space. A relationship between the position of vortices of magnetic induction and the variation in the electric field of the spin wave is found. It is established that, in the structures under consideration, the vector lines do not form vortices.

摘要： ME-344 [(3R, 4S)-3,4-bis(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol] is a second-generation derivative natural product isoflavone presently under clinical development. ME-344 effects were compared in lung cancer cell lines that are either intrinsically sensitive or resistant to the drug and in primary immortalized human lung embryonic fibroblasts (IHLEF). Cytotoxicity at low micromolar concentrations occurred only in sensitive cell lines, causing redox stress, decreased mitochondrial ATP production, and subsequent disruption of mitochondrial function. In a dose-dependent manner the drug caused instantaneous and pronounced inhibition of oxygen consumption rates (OCR) in drug-sensitive cells (quantitatively significantly less in drug-resistant cells). This was consistent with targeting of mitochondria by ME-344, with specific effects on the respiratory chain (resistance correlated with higher glycolytic indexes). OCR inhibition did not occur in primary IHLEF. ME-344 increased extracellular acidification rates in drugresistant cells (significantly less in drug-sensitive cells), implying that ME-344 targets mitochondrial proton pumps. Only in drug-sensitive cells did ME-344 dose-dependently increase the intracellular generation of reactive oxygen species and cause oxidation of total (mainly glutathione) and protein thiols and the concomitant immediate increases in NADPH levels. We conclude that ME-344 causes complex, redox-specific, and mitochondria-targeted effects in lung cancer cells, which differ in extent from normal cells, correlate with drug sensitivity, and provide indications of a beneficial in vitro therapeutic index.

关键词： VIRUS-like particles   GENE transfection   PLASMIDS   VIRAL vaccines   GAG proteins   CELL lines  

摘要： O10-3