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关键词： 肝癌   微波消融   临床疗效   预后  

摘要： 目的评估超声引导下微波消融一线治疗原发性肝癌的临床疗效以及预后影响因素。方法2010年6月到2014年11月，201例首次诊断为原发性肝癌的患者在本中心接受超声引导下微波消融治疗，随访时间4～53个月。使用单因素（Kaplan-Meier模型）以及多因素（Cox回归）分析对患者肿瘤复发以及生存的预后因素进行评估。结果肿瘤初次完全消融率为96％，部分患者接受了2次消融，总计完全消融率为99％。微波消融治疗后并发症发生率为5．6％（12／201）。患者术后平均无瘤生存时间为18个月、肝功能ChildB级、肿瘤多发、肿瘤直径〉5cm、AFP〉20μg／L是影响患者术后无瘤生存时间的独立危险因素。患者平均总生存时间为38个月，与之相关的独立危险因素为肝炎病史、肿瘤多发以及肿瘤直径〉5cm。结论超声引导下微波消融一线治疗原发性肝癌是安全和有效的，肿瘤直径、数量以及患者肝功能状况是影响患者预后的主要因素。

关键词： 壮医药线点灸   抑郁症   SP   NPY  

摘要： 目的:比较壮医药线与空线点灸对抑郁症患者临床疗效及血浆中P物质(Substance P,SP)和神经肽Y(Neuropeptide Y,NPY)的影响。方法:收集抑郁症患者60例,分为药线组(壮医药线点灸治疗)、空线组(空线点灸治疗)、对照组(百忧解口服治疗),每组20例,连续治疗6周,于治疗前、后采用放射免疫法检测患者血浆中SP和NPY的含量,并观察治疗前后汉密尔顿抑郁量表-17项(HAMD-17项)与抑郁自评量表(SDS)评分变化,以HAMD-17在治疗前后的减分率作为疗效评价指标进行临床疗效评价。另选10例健康体检者为正常参照,不做任何处理,设为正常对照组。结果:治疗后SP含量变化:药线组、对照组较治疗前均有明显下降(P<0.05)。治疗后NPY含量变化:药线组、空线组、对照组较治疗前均有明显上升(P<0.05)。治疗后HAMD-17项、SDS评分:药线组、空线组、对照组较治疗前均有明显下降(P<0.05),但药线组、对照组的减分率较空线组明显(P<0.01)。临床疗效:经过6周抗抑郁治疗,药线组有12例显效,显效率为60.0%,有效6例,有效率30.0%,总有效率为90.0%;空线组有2例显效,显效率为10.0%,有效8例,有效率40.0%,总有效率为50.0%;对照组有15例显效,显效率为75.0%,有效4例,有效率20.0%,总有效率为95.0%。药线组、对照组的疗效均优于空线组(P<0.01)。结论:壮医药线比空线点灸能更有效改善抑郁症患者血浆的SP含量及临床症状。

关键词： 终采线   超前支承压力   围岩   应力分布   支承压力  

摘要： 为确定工作面终采线的合理位置,结合理论计算与FLAC^(3D)模拟,研究不同终采线位置条件下巷道围岩的应力分布及变形破坏规律。结果表明:71311工作面超前支承压力的峰值位置距煤壁约为8m,影响范围在20m左右;当终采线与71312上区段平巷的距离为20m时,顶底板破坏深度趋于稳定;在考虑到安全生产及多采煤的情况下,确定终采线与上区段平巷的距离为20m。

关键词： 弹性地基反力法   m法   钻孔灌注桩   内力计算   变形计算  

摘要： 结合钻孔灌注桩内力及水平荷载下的变形计算,介绍了利用m法计算的方法和计算过程。在计算中将土体作为半无限体,实际工程迎水侧为斜坡,采用的水平抗力系数偏大,水平位移计算的结果比实际偏小。

关键词： Dual-grid level-set method   Traditional level-set method   Droplet impact   Contact line modeling   Non-bouncing   Bouncing  

摘要： In this paper, a numerical methodology for modeling contact line motion in a dual-grid level-set method (DGLSM) - solved on a uniform grid for interface which is twice that for the flow equations - is presented. A quasi-dynamic contact angle model - based on experimental inputs - is implemented to model the dynamic wetting of a droplet, impacting on a hydrophobic or a superhydrophobic surface. High-speed visualization experiments are also presented for the impact of a water droplet on hydrophobic surfaces, with non-bouncing at smaller and bouncing at larger impact velocity. The experimental results for temporal variation of the droplet shapes, wetted-diameter and maximum height of the droplet match very well with the DGLSM based numerical results. The validation of the numerical results is also presented with already Published experimental results, for the non-bouncing on a hydrophobic and bouncing on a superhydrophobic surface, at a constant impact velocity. Finally, a qualitative as well as quantitative performance of the DGLSM as compared to the traditional level set method (LSM) is presented by considering our experimental results. The accuracy of the partially refined DGLSM is close to that of the fine-grid based LSM, at a computation cost which is close to that of the coarse-grid based LSM. The DGLSM is demonstrated as an improved LSM for the computational multi-fluid dynamics (CMFD) simulations involving contact line motion. (C) 2016 Elsevier Ltd. All rights reserved.

关键词： Stress   influence line   weighted moving average   structural health monitoring   suspension bridge  

摘要： Numerous long-span suspension bridges have been built worldwide over the past few decades. To ensure the safety of such bridges and their users during the bridge service life, several bridges have been equipped with Structural Health Monitoring Systems (SHMSs), which measure dynamic bridge responses and various loading types on-site. Integrating SHMS and damage detection technology for condition assessment of these bridges has become a new development trend. Recent studies have proven that stress influence line (SIL)-based damage indices achieve excellent damage detection performance for a long suspension bridge. However, an accurate and prompt manner of identifying the SIL of a long suspension bridge is important to facilitate the development of the SIL for an effective damage index. Identifying the SIL from field measurement data under in-service conditions has several advantages over the traditional static loading test. This study proposes and develops a new SIL identification method by integrating the least squares solution and Weighted Moving Average (WMA) based on the measured train information and the corresponding train-induced stress time history. The efficacy of the proposed method is validated through its application to Tsing Ma Bridge (TMB). The good agreement between the identified and baseline SILs for a typical diagonal truss member verifies the effectiveness of the proposed method. Furthermore, robustness testing is performed by identifying SIL on the basis of information on different trains and train-induced stress responses and by identifying the SIL of different types of bridge components. Results indicate the feasibility of the application of the proposed approach to SIL identification for long-span bridges.

关键词： audit quality   auditor industry specialization   analyst forecast accuracy  

摘要： The accuracy and other properties of analyst earnings forecasts represent potentially useful proxies for the impact of audit quality on client financial reports. Extant research in the auditing literature, however, is characterized by diametrically opposite predictions and inconsistent findings regarding the relationship between audit quality and analyst forecast accuracy. We argue that a potential reason for the inconsistency in the literature reflects these studies' focus on end-of-year forecast accuracy, which is subject to competing effects of audit quality. High-quality auditors may simultaneously improve forecast accuracy through their impact on the decision usefulness of clients' prior period reports, and reduce forecast accuracy by constraining client attempts to manage earnings in the direction of the consensus forecast. We argue and present evidence in support of the conjecture that analysts' beginning-of-year forecasts are a superior metric for identifying the impact of audit quality on the properties of analyst forecasts because the decision usefulness effect of audit quality should be dominant with respect to those forecasts.

关键词： PERSONNEL management   INDUSTRIAL hygiene   MENTAL illness   STIGMA (Social psychology)  

摘要： The article focuses on a study from health solution provider Willis OMI Group which reveals the role of line managers to identify problems with mental health at work. It informs about the management practices guidelines of the National Institute for Clinical Excellence (NICE) Workplace Health. It also mentions signs and symptoms which indicate mental health issue such as anxiety and depression.

关键词： Ag thin-film line   Current-stressing experiment   Hot and humid environment   Electrical resistivity   Thermal transport  

摘要： To evaluate the reliability of Ag thin-film lines for a wide range of applications in electronic devices, knowledge of the thermal transport across the interface between the line and the underlying substrate is of great importance. This is because such thermal transport significantly affects the temperature distribution in the line, the electrical performance of the line and the service life of the device the line is installed on. In this work, we examine the influence of a hot and humid environment on the thermal transport across the interface between a Ag thin-film line and a substrate. By performing a series of current-stressing experiments using the four-point probe method at atmospheric conditions (296 K and 30 RH%) on a Ag thin-film line for different durations of exposure to a hot and humid environment (323 K and 90 RH%), the electrical resistivity was found to increase with the exposure duration. Such an increase is believed to be the result of a decrease in the interfacial thermal conductance, which indicates less thermal transport from the line to the substrate. Moreover, by observing the surface morphology changes in the line and conducting a one-dimensional electro-thermal analysis, such variations can be attributed to the generation and growth of voids within the line, which hinder heat transfer from the line to the substrate through the interface. (C) 2016 Elsevier B.V. All rights reserved.

关键词： Algorithms   Anatomy   Applied mathematics   Asia   Bacterial diseases   Biology and life sciences   Body fluids   Diagnostic medicine   Europe   Extensively drug-resistant tuberculosis   Geographical locations   Infectious diseases   Mathematics   Medicine and health sciences   Mucus   Multi-drug-resistant tuberculosis   People and places   Physical sciences   Physiology   Research and analysis methods   Research Article   Russia   Simulation and modeling   Sputum   Tropical diseases   Tuberculosis   Tuberculosis diagnosis and management  

摘要： Background In the Arkhangelsk region of Northern Russia, multidrug-resistant (MDR) tuberculosis (TB) rates in new cases are amongst the highest in the world. In 2014, MDR-TB rates reached 31.7% among new cases and 56.9% among retreatment cases. The development of new diagnostic tools allows for faster detection of both TB and MDR-TB and should lead to reduced transmission by earlier initiation of anti-TB therapy. Study Aim The PROVE-IT (Policy Relevant Outcomes from Validating Evidence on Impact) Russia study aimed to assess the impact of the implementation of line probe assay (LPA) as part of an LPA-based diagnostic algorithm for patients with presumptive MDR-TB focusing on time to treatment initiation with time from first-care seeking visit to the initiation of MDR-TB treatment rather than diagnostic accuracy as the primary outcome, and to assess treatment outcomes. We hypothesized that the implementation of LPA would result in faster time to treatment initiation and better treatment outcomes. Methods A culture-based diagnostic algorithm used prior to LPA implementation was compared to an LPA-based algorithm that replaced BacTAlert and Lowenstein Jensen (LJ) for drug sensitivity testing. A total of 295 MDR-TB patients were included in the study, 163 diagnosed with the culture-based algorithm, 132 with the LPA-based algorithm. Results Among smear positive patients, the implementation of the LPA-based algorithm was associated with a median decrease in time to MDR-TB treatment initiation of 50 and 66 days compared to the culture-based algorithm (BacTAlert and LJ respectively, p<0.001). In smear negative patients, the LPA-based algorithm was associated with a median decrease in time to MDR-TB treatment initiation of 78 days when compared to the culture-based algorithm (LJ, p<0.001). However, several weeks were still needed for treatment initiation in LPA-based algorithm, 24 days in smear positive, and 62 days in smear negative patients. Overall treatment outcomes were