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关键词： Adults   Age   Lip-line cant   Menton deviation  

摘要： Objective: The aims of this study were to assess the direction and degree of lip-line cant in Korean adult orthodontic patients and to identify the effects of sex and age on changes in the cant severity. Methods: In this cross-sectional retrospective study, lip-line cant was measured in the frontal photographs of 585 Korean patients (92 men and 493 women) aged 18-48 years. The outcome variables (direction and degree of lip-line cant) were assessed in terms of predictor variables (sex, age, sagittal skeletal relationship, and menton deviation angle). Results: The direction of lip-line cant did not differ according to sex, age, or skeletal classification. Patients had 1.6 of lip-line cant on average before orthodontic treatment. Middle-aged adults displayed a significant trend toward a lower degree of lip-line cant compared to younger adults (p < 0.01). Multiple linear regression analysis showed that the degree of lip-line cant was weakly negatively correlated with age (p < 0.001). Conclusions: While the direction of lip-line cant did not differ according to the parameters explored here, the degree of cant was correlated with age in adults, independent of menton deviation. Specifically, middle-aged adults tended to display significantly lower degrees of lip-line cant than did younger adults.

摘要： The Genea053 human embryonic stem cell line was derived from a donated, fully commercially consented ART blastocyst, carrying Trisomy 21, indicative of Down Syndrome. Following ICM outgrowth on inactivated human feeders, CGH and STR analysis demonstrated a 47, XY, + 21 karyotype and male allele pattern. The hESC line had pluripotent cell morphology and expressed pluripotent cell markers including 83% Nanog positive, 87% Oct4, 88% Tra1-60 and 98% SSEA4. The cell line was negative for Mycoplasma and visible contamination. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

摘要： The Genea050 human embryonic stem cell line was derived from a donated, fully commercially consented ART blastocyst, carrying a deletion in 4q35 with only 5 D4Z4 repeats by PGD linkage analysis, indicative of FSHD1. Following ICM outgrowth on inactivated human feeders, karyotype was confirmed as 46, XY and STR analysis demonstrated a male Allele pattern. The hESC line had pluripotent cell morphology, 92% of cells expressed Nanog, 97% Oct4, 79% Tra1-60 and 99% SSEA4, gave a Pluritest Pluripotency score of 25.45, Novelty of 1.45 demonstrated Alkaline Phosphatase activity and tri-lineage teratoma formation. The cell line was negative for Mycoplasma and visible contamination. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

摘要： The Genea018 human embryonic stem cell line was derived from a donated, fully commercially consented ART blastocyst, carrying Htt gene CAG expansion of 46 repeats, indicative of Huntington Disease. Following ICM outgrowth on inactivated human feeders, karyotype was confirmed as 46, XX by CGH and STR analysis demonstrated a female Allele pattern. The hESC line had pluripotent cell morphology, 75% of cells expressed Nanog, 91% Oct4, 73% Tra1-60 and 96% SSEA4, gave a Pluritest pluripotency score of 31.12, Novelty of 1.45, demonstrated Alkaline Phosphatase activity and tri-lineage teratoma formation. The cell line was negative for Mycoplasma and visible contamination. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

摘要： The Genea067 human embryonic stem cell line was derived from a donated, fully commercially consented ART blastocyst, carrying expansion of CTG repeats in the DMPK gene, indicative of Myotonic Dystrophy Type 1 (DM1). Following ICM outgrowth on inactivated human feeders, karyotype was confirmed as 46, XY and STR analysis demonstrated a male Allele pattern. The hESC line had pluripotent cell morphology, 85% of cells expressed Nanog, 97% Oct4, 73% Tra1-60 and 98% SSEA4 and gave a Pluritest Pluripotency score of 25.75, Novelty of 1.46. The cell line was negative for Mycoplasma and visible contamination. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Influence lines   Green's functions   Euler-Bernoulli beam   Elastic supports   Different boundary conditions  

摘要： This article presents an analytical method to draw influence lines and diagrams of variations for deflection, rotation, bending moment, and shearing force for a generally restrained Euler-Bernoulli beam. To do so, Green's function method is used. The Green's functions of the parameters are first derived and then used to obtain the influence lines and diagrams for variations in deflection, rotation, bending moment, and shearing force for different beams with different boundary conditions. Examples provide an indication of the accuracy of the proposed exact solution. (C) 2015 American Society of Civil Engineers.

摘要： The Genea090 human embryonic stem cell line was derived from a donated, fully commercially consented ART blastocyst, carrying Htt gene CAG expansion of 45 repeats, indicative of Huntington Disease. Following ICM outgrowth on inactivated human feeders, karyotype was confirmed as 46, XX by CGH and STR analysis demonstrated a female allele pattern. The hESC line had pluripotent cell morphology, 91% of cells expressed Nanog, 95% Oct4, 90% Tra1-60 and 100% SSEA4 and gave a pluritest pluripotency score of 30.91, novelty of 1.23. The cell line was negative for Mycoplasma and visible contamination. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Atlantic Canada   Sea level rise   Paraglacial   Barrier beach   Dune   Beach ridges   Tidal inlet   Ground-penetrating radar   Refraction seismic   Lithofacies  

摘要： Many coastlines are retreating in response to sea level rise, compounded by glacial-isostatic subsidence in areas marginal to former ice sheets. The resulting barrier and estuarine deposits are dominated by transgressive stratigraphy. Where supplied primarily from relict glacial deposits, this "paraglacial" sediment input may rise and fall, increasing as a new source such as a drumlin headland is exposed to erosion but declining as the source becomes exhausted. Conrads Beach, on the Atlantic coast of Canada, has experienced a succession of barrier growth and reworking as sediment supply from several drumlin sources has varied over the past 3000 years. In the context of long-term regional transgression, there have been intervals of years to centuries characterized by local stability or progradation. Ground-penetrating radar profiles and refraction seismic data were used to image the facies architecture of Conrads Beach to depths of 6-8 and 10-24 m, respectively. Thirteen vibracores provided a record of lithofacies characteristics and geometry. Results show evidence of an estuarine basin at similar to 2800 years BP. As the outer coast retreated, erosion of drumlins provided multi-century sediment pulses to adjacent beaches and embayments. Locally increased sediment supply fed a prograding beach ridge complex from > 600 to similar to 150 years BP and tidal channels feeding sediment to back-barrier flood delta deposits. This study documents the complexity of coastal adjustment to time- and source-varying sediment supply under long-term rising sea level. It expands and refines previous models, providing guidance required for effective management and hazard mitigation on transgressive paraglacial coasts.

关键词： Arthroplasty   epicondyle   joint line   knee MeSH terms: Knee replacement   total   osteoarthritis   knee   knee prosthesis  

摘要： Background: Hinged knee prosthesis is an effective treatment method as a salvage procedure in marked ligamentous insufficiency and severe bone defects. Joint line determination and restoration are difficult due to large bone defects and distorted anatomy. We evaluated the impact of joint line alteration on the outcome in rotating hinge knee arthroplasty (RHKA). Materials and Methods: 35 patients who had rotating hinged knee prosthesis applied between 2008 and 2013 were evaluated in this retrospective study. The patients were studied radiologically and clinically. Five patients were lost to followup and two patients died, leaving a total of 28 (7 male, 21 female) patients for final evaluation. The average age of the patients was 66.19 8.35 years (range 52u83 years). The patients were evaluated clinically with Knee Society knee and functional score and patellar score. The joint line positions were evaluated radiographically with femoral epicondylar ratio method. The outcomes were also evaluated according to age, body weight and gender. Student's t-test, independent t-test, and the Wilcoxon signed rank test were used in the statistical analysis. Results: The mean Knee Society knee and functional score significantly improved from preoperative 19.52 11.77 and 12.5 15.66 respectively to 72.46 14.01 and 70.36 9.22 respectively postoperatively (P 0.001). The mean range of motion of the knee improved from 55.95 degrees 25.08 degrees preoperatively to 92.14 degrees 13.47 degrees postoperatively (P 0.001). Joint line position was restored in 20 patients (71.4%). Joint line alteration did not affect Knee Society Scores (KSSs) in contrast to patellar scores. Additionally, KSS was better in the patients with body mass index %30 at followup (P = 0.022 and P = 0.045). Conclusion: RHKA is an effective salvage procedure for serious instability and large bone defects. Restoration of the joint line improves the patellar score although it had no effect on the clinical outcome.

关键词： Solanum lycopersicum   FORL resistance   Necrotrophic pathogen   Transcriptomic   Callose deposition   Dehydration-induced protein   Oxidative burst   Necrosis reaction  

摘要： Background: Fusarium oxysporum ***. radicis-lycopersici (FORL) is one of the most destructive necrotrophic pathogens affecting tomato crops, causing considerable field and greenhouse yield losses. Despite such major economic impact, little is known about the molecular mechanisms regulating Fusarium oxysporum ***. radicis-lycopersici resistance in tomato. Results: A transcriptomic experiment was carried out in order to investigate the main mechanisms of FORL response in resistant and susceptible isogenic tomato lines. Microarray analysis at 15 DPI (days post inoculum) revealed a distinct gene expression pattern between the two genotypes in the inoculated vs non-inoculated conditions. A model of plant response both for compatible and incompatible reactions was proposed. In particular, in the incompatible interaction an activation of defense genes related to secondary metabolite production and tryptophan metabolism was observed. Moreover, maintenance of the cell osmotic potential after the FORL challenging was mediated by a dehydration-induced protein. As for the compatible interaction, activation of an oxidative burst mediated by peroxidases and a cytochrome monooxygenase induced cell degeneration and necrosis. Conclusions: Our work allowed comprehensive understanding of the molecular basis of the tomato-FORL interaction. The result obtained emphasizes a different transcriptional reaction between the resistant and the susceptible genotype to the FORL challenge. Our findings could lead to the improvement in disease control strategies.