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关键词： 空间网格结构   地震反应分析   固有振型   Eigen-LDR振型叠加法  

摘要： 分析总结了传统振型叠加方法应用于空间网格结构动力反应分析难以适用的原因,结合结构固有振型与高效动力分析的LDR振型,提出一种基于振型遴选与振型构造的动力反应分析算法。采用Matlab进行编程,并对两个典型空间网格结构进行数值模拟分析。通过数值结果比较,验证该方法的正确性、有效性及其计算效率。

关键词： 轨道交通   住房价格   特征价格   计量分析   南京地铁  

摘要： 本文从理论和实证角度,分析验证了城市轨道交通对沿线站点住房价格的影响。首先通过理论分析提出假说,然后基于特征价格方法构建计量分析模型,利用南京市地铁1、2号线站点附近2km范围内二手楼盘数据,实证分析了城市轨道交通地铁对沿线站点住房价格的影响。结果表明:1城市轨道交通对沿线站点住房价格产生了显著的增值效应,不同距离范围影响程度不同,距地铁站点500m以内住房价格比500m以外高出14.3%,1 000m以内住房价格比1 000m以外高出8.9%,1 500m以内住房价格比1 500m以外高出3.9%,当距离范围超过1 500m后,增值效应在统计上不显著;2轨道交通对住房价格的影响程度与距地铁站点直线距离存在着显著的倒"U"形关系,影响程度随距离先增大后减小,在距地铁站点大约320m时影响程度最大;3轨道交通对沿线站点住房价格的影响程度具有显著的分市场效应,对郊区市场的影响程度要远大于主城区市场。

关键词： Benomyl   Carbendazim   MCF-7   Inhibition of HDAC1   Acetylated histone H3   Indirect measurement of aromatase activity  

摘要： The carbamate fungicide benomyl reportedly inhibited the growth of the human breast cancer cell line MCF-7 by inducing apoptosis. However, influence of benomyl on the expression and activity of aromatase of MCF-7 cells remains to be examined, since benomyl was identified as an endocrine disruptor. We here confirmed through cell cycle analysis and immunofluorescence staining that benomyl damaged microtubules and caused apoptosis. We also found that benomyl inhibited histone deacetylase (HDAC) 1 and accumulated acetylated histone H3 in MCF-7 cells. Additionally, benomyl enhanced the levels of aromatase protein and mRNA, albeit at high concentrations. It is thus likely that benomyl enhanced the promoter activity of the aromatase gene via acetylation of histone H3 as does the HDAC inhibitor Vorinostat. In conclusion, benomyl remains to be a risk factor as an endocrine disruptor for breast cancer. (C) 2014 Elsevier B.V. All rights reserved.

关键词： DEEPWATER Horizon (Drilling rig)   OIL well drilling rigs   OIL spills   ENVIRONMENTAL disasters   MENTAL health   HEALTH impact assessment  

摘要： The stress and grief that follow disaster trauma are normal reactions to an abnormal event. As such, the majority of people affected will recover without any interventions, while others will be affected more significantly. There are several important risk factors to consider when assessing the impact of disaster trauma on individuals and communities. These include the type and scope of the disaster, the proximity of the individual to the epicenter of the disaster, perception of threat to one’s life, degree of loss, previous experiences of any type of trauma, and the availability of social and emotional supports. In addition, access to services to meet basic needs (food, shelter, and clothing) will influence the degree of trauma experienced.

关键词： Influence line   Maximum likelihood estimator   Weigh-in-motion   Signal processing  

摘要： This paper presents an algorithm that estimates the influence line (IL) of a bridge using data collected when trucks pass over the sensors installed in the bridge. The algorithm is tested with data collected from the Millau Viaduct in France using a bridge weigh-in-motion (B-WIM) device. The algorithm uses the maximum likelihood estimation (MLE) and is compared with an old algorithm. The algorithm is more robust because it takes into account many signals for the estimation of the IL. (C) 2014 American Society of Civil Engineers.

关键词： Data assimilation   Simulation   SAARC-STORM   NCEP-FNL   TRMM  

摘要： A widespread thunderstorm (squall line or multicell line) occurred over Bangladesh on 11 May 2011 during 0300 UTC to 1300 UTC. A north-south oriented well-established squall line of 400 km length was noticed to the center of Bangladesh at 0530 UTC and the vertical extend of this system was about 16-18 km. An attempt has been made to study the impact of data assimilation in simulation of the selected thunderstorm event of 11 May 2011 using Weather Research and Forecasting (WRF) model. The WRF model was run in STORM Phase-I domain at 9 km horizontal resolution using six hourly NCEP-FNL datasets from 0000 UTC of 11 May to 0000 UTC of 12 May 2011 as initial and boundary condition for control (CNTL) run. The 0300 UTC Synop, 0000 UTC Temp and 0300 UTC Khepupara DWR reflectivity and redial velocity of 11 May 2011 were assimilated in 3DVar with the first guess of WRF model for data assimilation (DA) run. Model outputs have been analyzed for CNTL and DA to compare and/or asses the model performance. It is found that the DA enhanced in the synoptic and environmental characteristics as compared to that of CNTL. The WRF model outputs with DA help to investigate the synoptic and environmental characteristics responsible for the occurring of this unusual event. The model products showed a cyclonic circulation over Gangetic West Bengal of India at 925 hPa and over Assam and adjoining areas of India at 500 hPa. Strong upward motion was noticed over Bangladesh. Significant moisture incursion was observed over center and southeast parts of Bangladesh at 925 and 850 hPa with southerly/southwesterly flow of 10-20 ms(-1) (19-39 knots). Result showed that the WRF model with DA could capture thunderstorm event of 11 May 2011 in reasonably well though there are some spatial and temporal biases in the results.

关键词： MENTAL health services   EPIDEMIOLOGY   DEEPWATER Horizon (Drilling rig)   OIL spills   PUBLIC health   ENVIRONMENTAL disasters  

摘要： Two large-scale epidemiologic federal surveys conducted in the Gulf Coast following the Deepwater Horizon oil spill and intended to measure its impact on mental disorders and substance use found less dramatic results than had been anticipated. However, several smaller-scale studies conducted shortly after the spill did find increases in the prevalence of certain psychological problems among individuals surveyed. Previous federal studies conducted following two disasters-the destruction of the World Trade Center (WTC) and Hurricanes Katrina and Rita-found few statistically significant changes in behavioral disorders in the wake of those events, except for individuals displaced from their homes by Katrina for 2 weeks or more. In this commentary, the authors discuss questions raised by these mixed results regarding the limitations of such studies, the behavioral health impact of the Deepwater Horizon spill compared to disasters causing more widespread loss of life and destruction of property, and the ways in which data collection following disasters might be improved to benefit public health planners.

关键词： INNOVATION management   RESEARCH & development   FINANCE   EUROPE -- Economic conditions   ECONOMIC aspects  

摘要： The EU’s stagnation on many innovation indicators led to a number of efforts to spur a turnaround. One of most visible projects has been the Horizon 2020 strategy, which devotes unprecedented levels of funding to the promotion of R&D and innovation. But does this strategy address the right issues to promote innovation? Is Horizon 2020 right to ignore geographical considerations when allocating funding? What policy instruments does Horizon 2020 recommend, and has it led to novel strategies being employed, beyond the increase in R&D funding? What steps are individual countries taking? Most importantly, what impact is Horizon 2020 actually having on innovation in the EU? © 2015, ZBW and Springer-Verlag Berlin Heidelberg.

关键词： 企业铁路   运输效率   因素   对策  

摘要： 本文通过对影响企业铁路专用线运输效率因素的分析，为优化组织，提高运输效率，结合车站布局特点及作业分工，引入企业铁路车站“一体化管理”运输模式，强调填写技术作业大表，编制阶段计划，系统掌握企业列车运行、机车动态、调车作业、装车进度，最大限度做到工种融合，达到全面提高专用线运输效率。

关键词： Chromosomal aberration   Municipal landfill   Leachate   Heavy metal   Channa striata  

摘要： The objectives of this study are to investigate chromosomal aberrations of snakehead fish in a leachate-affected reservoir located 100 meters from a municipal landfill which compared to non-affected reservoir. Three snakehead fish were collected and chromosomal aberrations were studied using kidney tissue. Lead and mercury were measured in water, sediment and snakehead fish from the affected reservoir at three sampling sites. The results showed that the average concentrations of lead and mercury in water were 0.0012 +/- 0.0003 and 0.0053 +/- 0.0036 mg/L, respectively. The average concentrations of lead and mercury in sediment were 3.3650 +/- 2.1930 and 0.0890 +/- 0.0272 mg/kg, respectively. These values did not exceed the standard for water and soil quality except for the mercury in the water, which was higher than acceptable. Lead was not found in snakehead fish from either reservoir. The average concentrations of mercury in snakehead fish from both reservoirs were 0.1330 +/- 0.0792 and 0.1180 +/- 0.0350 mg/kg, respectively, which were higher than the standard for mercury contamination in food. This study showed that the accumulation of mercury in snakehead fish was higher than in sediment because it accumulates in organisms through the consumption hierarchy. The diploid chromosome number of snakehead fish in both reservoirs was 2n = 42 and the percentage of chromosomal breakages of snakehead fish in the affected reservoir was higher than the non-affected reservoir. There were four types of chromosomal breakages: single chromatid gap, isochromatid gap, single chromatid breaks and isochromatid breaks. The difference in percentage of chromosomal breakages in snakehead fish from both reservoirs was statistically significant (p<0.05).