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关键词： 分子免疫学   免疫遗传学   免疫学技术   征订启事   临床免疫学   中华医学会   肿瘤免疫学   临床微生物学  

摘要： 《中华微生物学和免疫学杂志》为中华医学会主办。1981年创刊,主要报道医学微生物学和免疫学方面的研究论文、简报、评论、综述、国内外学术动态、书评及消息等。本刊辟有:细菌学、病毒学、分子微生物学、临床微生物学、疫苗学、感染免疫、基础免疫学、临床免疫学、分子免疫学、免疫遗传学、肿瘤免疫学、中药与免疫、免疫学技术、检测技术等栏目。

关键词： Y染色体   群体遗传学   隔离人群   遗传亚结构  

摘要： 中国西南地区分布着众多少数民族,同时也包含许多地理和遗传隔离的人群,然而这些族群的遗传结构,特别是父系遗传结构缺乏深度解析。本研究采用Y染色体捕获及Illumina测序技术,对西南地区3个隔离人群男性无关个体样本,包括四川平武县的白马人、石棉县的木雅人及云南景洪市空格人,通过定点复合扩增检测,直接计数法计算相关单倍群频率,应用Past3.0软件进行PCA(principle component analysis,PCA)主成分分析并绘制群体聚类树,研究了3个族群的父系遗传结构,并探讨其遗传亚结构关系。本研究共观察到云南空格人三种Y染色体单倍群、四川白马人四种Y染色体单倍群以及木雅人五种Y染色体单倍群。结果表明,空格人与佤族的父系遗传关系最近;而白马人和木雅人主要集中在D单倍群及其下游,研究提示着白马人和四川羌族的父系遗传关系最近;木雅人与昌都地区藏族和林芝地区藏族父系遗传关系最近。本文对不同族群遗传结构的分析,丰富了我国隔离人群遗传关系的研究成果。

关键词： 医学遗传学   中华医学会系列杂志   快速通道   国际学术交流   人类遗传学   重大研究成果   选稿原则  

摘要： 为了尽快将我国医学遗传学、人类遗传学及相关领域中的新发现和重大研究成果在本刊发表,以促进国内和国际学术交流。我们按照中华医学会系列杂志的管理要求,对作者的来稿开辟了“快速通道”。为了使广大作者、读者了解和充分利用“快速通道”,特将“快速通道”选稿原则和申请要求公布如下。

关键词： 高校教育   思政教育   教学   人才培养  

摘要： 立德树人是高校的根本任务,新形势下,思政教育是高校教育的必然趋势,也是青年学者开阔视野、增长见识、提升基本素养的必要途径。遗传学及其相关课程是生命科学方向本科生的专业基础课,其教学内容多角度、多层次,从分子、细胞、个体和群体的水平讲授生物性状形成及其在代间传递的遗传基础、性状变异的原因及在自然/人工选择下的变化规律。遗传学的丰富理论也蕴涵了丰富的思政教育素材。本研究立足遗传学理论的教学,多方位、多角度挖掘其中的思政要点,找准学生的兴趣点,提升课堂吸引力与关注度,施行教学改革实践,旨在凝练遗传学文化和遗传学思想,引领思政内涵,让思政教育能“润物细无声”地融入遗传学专业教学的改革实践中,提升高校教育质量,为实现中华民族伟大复兴输送有思想、高素质的人才。

关键词： 遗传学  

ISBN: (纸本)9787030711267

摘要： 本书共14章, 包括遗传物质的结构、功能以及传递规律, Mendel定律及其扩展, 性别决定与伴性遗传, 连锁互换与基因作图, 细菌与噬菌体的遗传, 基因组学和蛋白质组学, 遗传重组, 染色体畸变, 基因突变, 表观遗传学, 细胞质遗传, 数量性状的遗传, 基因调控与发育, 群体遗传与进化等。

摘要： Artificial morphogenesis (or morphogenetic engineering) seeks inspiration from developmental biology to engineer self-organizing systems. The Morphgen language uses partial differential equations (PDEs) to express artificial morphogenetic processes as spatial fields describing large numbers of agents in the continuum limit. I present an approach to compile such systems of PDEs by discretizing their behavior to derive controllers for finite numbers of agents of finite size. This approach builds on a generalization of methods to control swarms of robots based on the computational fluid dynamics technique of smoothed particle hydrodynamics (SPH). I address potential scalability and efficiency challenges in SPH robotics by proposing embodied kernel functions that allow key operations to be offloaded to the physical environment. These kernel functions assume the ability of agents to produce local physical fields with certain properties. I especially explore the possibility of cell-like agents able to control the secretion rate of morphogens that diffuse and are degraded in an aqueous medium. I present strategies to mitigate gaps between simplifying assumptions and expected realities. I explore in simulation the validity, accuracy, and robustness of these strategies and of my overall approach.

摘要： Beluga whales (Delphinapterus leucas) migrated to the St. Lawrence Estuary near the end of the Holocene glacial retreat, when dry land emerged. The population currently inhabiting the St. Lawrence shows strong site fidelity, which is generally common with belugas. Decades after a ban on the hunting of the beluga whale in 1979, the lack of recovery noticed in the St. Lawrence Estuary (SLE) population has puzzled researchers who study beluga whales. The St. Lawrence Estuary has been known for its industrialization, as well as its large amounts of vessel traffic, contributing to entanglements, as well as pollution to the river and its inhabitants. The current population of belugas inhabiting the SLE are ~1000 or less, and are declining, which is concerning because the species as a whole are endangered. This research project focuses on assessing the threat of inbreeding and low genetic diversity on the small, isolated population of the SLE beluga. To estimate the degree of inbreeding, as well as the loss of genetic diversity within the SLE beluga, Arctic samples from Nunavik were genotyped using multiplex PCR and capillary electrophoresis for the creation of microsatellite profiles for each individual. The microsatellite profiles of the Nunavik individuals were then compared to with those from the SLE beluga that had previously been genotyped. The effective population size (Ne) was also estimated for the SLE population.

关键词： 表观遗传学   男性不育症   中药   DNA甲基化   组蛋白修饰   非编码RNA  

摘要： 表观遗传学是生命科学领域后基因时代的研究热点,应用表观遗传修饰研究方法 是男性不育症发病机制研究的前沿领域,亦是探索中医药治疗男性不育症靶点并阐释其作用机制的新途径.目前,男性不育症的病因病机尚未完全明确,现代医学尚无较好疗法,而中医药治疗男性不育症具有独特的优势和广阔的前景.新近研究发现,中医药能参与调控异常表观遗传修饰而治疗男性不育症.本文主要从男性不育症中医理论的表观遗传学基础以及从DNA甲基化、组蛋白修饰和非编码RNA三个方面在男性不育症治疗及中医药研究中的应用入手,多学科交叉,评述中医药治疗男性不育症的表观遗传作用,以期为中医药治疗该病提供新的科学依据和新思路.